Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH [PDF]
Open Biology, 2023 G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation ...
Xiao Han +2 more
exaly +5 more sources
Radiopharmaceutical application of TRK-950, an anti-CAPRIN-1 therapeutic antibody [PDF]
Journal of Cancer Research and Clinical OncologyPurpose Tumor imaging or therapy using cancer specific carriers combined with a radioisotope has huge potential. In radiopharmaceutical development, it is important to ensure target specificity and minimal binding to normal tissues for both tumor ...
David Kryża +2 more
exaly +4 more sources
Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer [PDF]
Journal of Translational Medicine, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment will develop new strategies to ...
Yuhang Sui, Xina Li, Hongtao Tan
exaly +3 more sources
MicroRNA-181a Functions as an Oncogene in Gastric Cancer by Targeting Caprin-1 [PDF]
Frontiers in Pharmacology, 2019 MicroRNA-181a (miRNA-181a) is a multifaceted miRNA implicated in various cellular processes, particularly in cell fate determination and cellular invasion.
Qiang Lu, Yanchun Chen, Shukun Wang
exaly +4 more sources
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1 [PDF]
Nature Communicationsβ-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder caused by mutations in the WDR45 gene, yet its molecular mechanisms remain poorly understood.
Yin Li +16 more
doaj +3 more sources
Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP [PDF]
Journal of Translational Medicine, 2023 Background Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is implicated in cancer cell proliferation and tumorigenesis; however, its role in the development of esophageal carcinoma (ESCA) has not been examined.
Yan Gao +7 more
doaj +2 more sources
RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response [PDF]
eLife, 2015 In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expression ...
Agnieszka Konopacka +4 more
doaj +2 more sources
Expression and tumor-promoting effects of caprin-1 in human glioma
Glioma, 2018 Background: Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is a newly discovered RNA-binding protein and is now recognized as one of the putative oncogenes.
Li Zhang +9 more
doaj +2 more sources
Caprin controls follicle stem cell fate in the Drosophila ovary.
PLoS ONE, 2012 Adult stem cells must balance self-renewal and differentiation for tissue homeostasis. The Drosophila ovary has provided a wealth of information about the extrinsic niche signals and intrinsic molecular processes required to ensure appropriate germline ...
John Reich, Ophelia Papoulas
doaj +3 more sources
Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts? [PDF]
eJournal of Oral Maxillofacial ResearchObjectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about ...
Nelli Yildirimyan +2 more
doaj +2 more sources