Results 131 to 140 of about 64,951 (237)

Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections. [PDF]

, 1989
In rats respiratory tract infections due to Sendai virus and coronavirus usually are transient, but they can have long-lasting consequences when accompanied by Mycoplasma pulmonis infections.
Haskell, A, Huang, HT, McDonald, DM
core  

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells

Cancer Management and Research, 2018
Rong-Jaan Lin,1,2 I-Jung Wu,1,2 Jo-Yu Hong,3 Bang-Hung Liu,4 Ruei-Yue Liang,4 Tein-Ming Yuan,5 Show-Mei Chuang4,6,7 1College of Life Sciences, National Chung Hsing University, 2Taichung Hospital, Ministry of Health and Welfare, 3Bachelor Program of ...
Lin RJ, Wu IJ, Hong JY, Liu BH, Liang RY, Yuan TM, Chuang SM   +6 more
doaj  

Analytical Quality by Design‐Guided Optimisation and Validation of a Short‐Run Stability‐Indicating Reverse‐Phase Ultra‐Fast Liquid Chromatography (RP‐UFLC) Method for the Quantitation of Nonivamide

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT Nonivamide (NON), a capsaicin analogue with similar pharmacological effects, is used in pain management, yet limited information exists on its accurate quantification by reverse‐phase liquid chromatography. A cost‐effective, efficient and precise RP‐HPLC method was developed, optimised using response surface methodology (central composite ...
Phindile Mahlangu, Madan S. Poka, Pedzisai A. Makoni, Bwalya A. Witika   +3 more
wiley   +1 more source

Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Introduction Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment—from the peripheral to central terminals—is key to this effort ...
Julia R. Sondermann, Allison M. Barry, Feng Xian, Thomas Haberl, David Gomez‐Varela, Fritz Benseler, Dietmar Schreiner, Nils Brose, Noa Lipstein, Manuela Schmidt   +9 more
wiley   +1 more source

Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah, Ali Soleimani, Ali Nouri, Melika Fallah, Alireza Haghighi, Ahmad Reza Dehpour, Abolfazl Zendehdel, Soraiya Ebrahimpour‐Koujan   +7 more
wiley   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Bowden, S, Brust, A, Cesare, P, Colless, B, Drew, LJ, Gale, JE, Heinzmann, S, Lewis, RJ, Robinson, M, Rugiero, F, Wood, JN   +11 more
core  

Gastric hemorrhage due to high pungency food?

JPGN Reports, Volume 7, Issue 2, Page 278-280, May 2026.
Abstract We present a case of a 9‐year‐old patient who presented with hematemesis after consuming crisps with a high pungency (the so‐called ghost peppers). Blood loss resulted in a significant decrease in hemoglobin and for this reason a gastroduodenoscopy was performed.
Rachel J. van der Pol, Anemone van den Berg, Wendy L. van der Woerd   +2 more
wiley   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source