Results 121 to 130 of about 298,386 (364)
eLife, 2018 The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in the absence of icosahedral symmetry ...
Jodi A. Hadden +5 more
semanticscholar +1 more source
Advanced Intelligent Discovery, EarlyView.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
Nature, 2016 During the early stages of infection, the HIV-1 capsid protects viral components from cytosolic sensors and nucleases such as cGAS and TREX, respectively, while allowing access to nucleotides for efficient reverse transcription.
D. Jacques +5 more
semanticscholar +1 more source
Annals of Neurology, EarlyView.Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell +3 more
wiley +1 more source
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]
, 2015 Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston +5 more
core
Inhibitors of the HIV-1 capsid, a target of opportunity
Current Opinion in HIV and AIDS, 2018 Purpose of review To summarize recent advances in the discovery of chemical inhibitors targeting the HIV capsid and research on their mechanisms of action. Recent findings HIV infection is critically dependent on functions of the viral capsid.
Stephanie K. Carnes +2 more
semanticscholar +1 more source
Micro/Nanorobot for Drug Delivery—A Review of Material Selections
Advanced NanoBiomed Research, EarlyView.This review explores material strategies for biomedical micro/nanorobots, emphasizing their roles in propulsion, navigation, drug delivery, and biodegradability. It highlights advancements in metallic, polymeric, and hybrid materials, while addressing clinical translation challenges such as toxicity, immune response, and manufacturability.
Xiaozhuo Wu, Bingyun Li, Malcolm Xing
wiley +1 more source
Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. [PDF]
, 2019 Herpesviruses are enveloped viruses that are prevalent in the human population and are responsible for diverse pathologies, including cold sores, birth defects and cancers.
Bi, Guo-Qiang +4 more
core
Chiral Quasicrystalline Order and Dodecahedral Geometry in Exceptional Families of Viruses
, 2012 On the example of exceptional families of viruses we i) show the existence of a completely new type of matter organization in nanoparticles, in which the regions with a chiral pentagonal quasicrystalline order of protein positions are arranged in a ...
C. Janot +10 more
core +5 more sources
The Astrovirus Capsid: A Review
Viruses, 2017 Astroviruses are enterically transmitted viruses that cause infections in mammalian and avian species. Astroviruses are nonenveloped, icosahedral viruses comprised of a capsid protein shell and a positive-sense, single-stranded RNA genome.
C. Arias, R. DuBois
semanticscholar +1 more source