Results 101 to 110 of about 249,247 (291)
Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
mBioLenacapavir (LEN) is the first-in-class viral capsid protein (CA) targeting antiretroviral for treating multi-drug-resistant HIV-1 infection. Clinical trials and cell culture experiments have identified resistance-associated mutations (RAMs) in the ...
Lorenzo Briganti +18 more
doaj +1 more source
A minimal representation of the self-assembly of virus capsids
, 2013 Viruses are biological nanosystems with a capsid of protein-made capsomer units that encloses and protects the genetic material responsible for their replication.
Breton, J. +2 more
core +1 more source
Investigating the Heat Stability and Inactivation Conditions of Decapod Iridescent Virus 1 (DIV1)
Animal Research and One Health, EarlyView.Heat treatment effectively inactivates decapod iridescent virus 1 (DIV1) under milder conditions than current WOAH recommendations. DIV1 infectivity was eliminated at 56°C for 30 min, 60°C for 15 min, or 70°C for 1 min, providing optimized heat treatment strategies for aquaculture biosecurity and seafood safety.
Yonghui Feng +4 more
wiley +1 more source
Animal Research and One Health, EarlyView.Field samples from breeder duck farms with egg‐production decline were subjected to viral detection, genome sequencing, and virus isolation. Experimental infection demonstrated that duck orbivirus (DORV) causes a significant and persistent reduction in egg production in breeder ducks.
Bing Li +18 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai +9 more
wiley +1 more source
A Mechanistic Model of rAAV Production in Synthetic Cell Lines
Biotechnology and Bioengineering, EarlyView.ABSTRACT The recombinant adeno‐associated virus (rAAV) is a widely used vector for gene therapy. Its manufacturing faces significant challenges in producing the large quantities of vectors needed for clinical applications and reducing empty particles.
Prahalad Srinivasan +5 more
wiley +1 more source
Role of dynamic capsomere supply for viral capsid self-assembly
, 2015 Many viruses rely on the self-assembly of their capsids to protect and transport their genomic material. For many viral systems, in particular for human viruses like hepatitis B, adeno or human immunodeficiency virus, that lead to persistent infections ...
Boettcher, Marvin A. +2 more
core +1 more source
The Canadian Entomologist, 1903 Lygus Chagnoni, n. sp.— This species of the genus Lygus is of a form near to L. pabulinus, Linn., in appearance.It is ovate, convex bright green in living specimens, with irregular purplish-brown markings at the base of the membrane, smooth and without bristles, and a silky pubesecence on the sides of the pronotum, which has an orange-yellow border ...
openaire +1 more source
Spontaneous regression of equine sarcoids is an exceptional event
Equine Veterinary Journal, EarlyView.Abstract Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition.
Sabine Brandt
wiley +1 more source
Antibody Competition Reveals Surface Location of HPV L2 Minor Capsid Protein Residues 17–36
Viruses, 2017 The currently available nonavalent human papillomavirus (HPV) vaccine exploits the highly antigenic L1 major capsid protein to promote high-titer neutralizing antibodies, but is limited to the HPV types included in the vaccine since the responses are ...
Stephanie M. Bywaters +5 more
doaj +1 more source