Results 1 to 10 of about 2,267 (171)

CPSF6 Promotes HIV-1 Preintegration Complex Function. [PDF]

Journal of Virology
Cleavage and polyadenylation specificity factor 6 (CPSF6) is part of the cellular cleavage factor I mammalian (CFIm) complex that regulates mRNA processing and polyadenylation.
Christopher Aiken, Alan N Engelman, Chandravanu Dash   +2 more
exaly   +6 more sources

CPSF6 Regulates Alternative Polyadenylation and Proliferation of Cancer Cells Through Phase Separation

Cell Reports, 2023
Summary: Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration.
Anlong Xu
exaly   +5 more sources

HIV-1 Infection Regulates Gene Expression by Altering Alternative Polyadenylation Correlated With CPSF6 and CPSF5 Redistribution [PDF]

MBio
HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Felipe Diaz-Griffero, Eric J Wagner, Annie Zhi Dai   +2 more
exaly   +4 more sources

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate From Nonprimate Lentiviral Integration.

MBio, 2020
Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral ...
Gregory Alan Sowd, Parmit K Singh, Alan N Engelman   +2 more
exaly   +5 more sources

NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression

Cancer Management and Research, 2020
Bi-Jun Wang,1,* Da-Chao Liu,1,* Qian-Ying Guo,2,* Xiao-Wen Han,2 Xiao-Min Bi,2 Hao Wang,2 Zheng-Sheng Wu,2 Wen-Yong Wu1 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ...
Zheng-Sheng Wu
exaly   +7 more sources

HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells

Viruses
The HIV-1 capsid (CA) protein forms the outer shell of the viral core that is released into the cytoplasm upon infection. CA binds various cellular proteins, including CPSF6, that direct HIV-1 integration into speckle-associated domains in host chromatin.
Anabel Guedan, Kate N Bishop
exaly   +4 more sources

CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Background Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini.
Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, Tao Zhu, Jielin Sun, Xiaodong Zhao   +11 more
doaj   +3 more sources

Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

Frontiers in Genetics, 2021
Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Yani Kang, Keshuo Ding, Jielin Sun
exaly   +3 more sources

In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects. [PDF]

PLoS Pathogens, 2014
The host protein CPSF6 possesses a domain that can interact with the HIV-1 capsid (CA) protein. CPSF6 has been implicated in regulating HIV-1 nuclear entry. However, its functional significance for HIV-1 replication has yet to be firmly established. Here
Matthew S Henning, Brittany N Dubose, Mallori J Burse, Christopher Aiken, Masahiro Yamashita   +4 more
doaj   +2 more sources

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

Scientific Reports, 2023
The early events of HIV-1 infection involve the transport of the viral core into the nucleus. This event triggers the translocation of CPSF6 from paraspeckles into nuclear speckles forming puncta-like structures.
Charlotte Luchsinger, KyeongEun Lee, Gonzalo A. Mardones, Vineet N. KewalRamani, Felipe Diaz-Griffero   +4 more
doaj   +1 more source