CPSF6 promotes HIV-1 preintegration complex function [PDF]
Journal of VirologyCleavage and polyadenylation specificity factor 6 (CPSF6) is part of the cellular cleavage factor I mammalian (CFIm) complex that regulates mRNA processing and polyadenylation.
Evan Chaudhuri +15 more
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Cell Reports, 2023 Summary: Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration.
Anlong Xu, Liutao Chen, Shangwu Chen
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CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression [PDF]
Journal of Experimental and Clinical Cancer Research, 2021 Background Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini.
Ming Zhang, Zhengsheng Wu, Yani Kang
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IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer [PDF]
Clinical and Translational MedicineBackground N6‐methyladenosine (m6A) and alternative polyadenylation (APA) are common posttranscriptional regulatory mechanisms in eukaryotes. However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear.
Xin Luo +14 more
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Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles [PDF]
eLifeViruses rely on host cellular machinery for replication. After entering the nucleus, the HIV genome accumulates in nuclear niches where it undergoes reverse transcription and integrates into neighbouring chromatin, promoting high transcription rates and ...
Chiara Tomasini +13 more
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CPSF6-mediated alternative polyadenylation of RUNX1 to regulate silica-induced pulmonary fibrosis progression [PDF]
Respiratory ResearchBackground Pulmonary fibrosis occurs when myofibroblasts and the extracellular matrix (ECM) excessively accumulate in the lung interstitium. Detailed studies elucidating the role of cleavage and polyadenylation-specific factor 6 (CPSF6) during fibroblast-
Huanyu Yang +5 more
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HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution [PDF]
mBioHIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Charlotte Luchsinger +9 more
doaj +2 more sources
Frontiers in Genetics, 2021 Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Yani Kang, Sheng Tan
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In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects [PDF]
PLoS Pathogens, 2014 The host protein CPSF6 possesses a domain that can interact with the HIV-1 capsid (CA) protein. CPSF6 has been implicated in regulating HIV-1 nuclear entry. However, its functional significance for HIV-1 replication has yet to be firmly established. Here
Christopher R Aiken, Masahiro Yamashita
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Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells. [PDF]
PLoS PathogensHuman immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV ...
Daphne Cornish +12 more
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