Results 1 to 10 of about 1,804 (117)

CPSF6-mediated alternative polyadenylation of RUNX1 to regulate silica-induced pulmonary fibrosis progression [PDF]

Respiratory Research
Background Pulmonary fibrosis occurs when myofibroblasts and the extracellular matrix (ECM) excessively accumulate in the lung interstitium. Detailed studies elucidating the role of cleavage and polyadenylation-specific factor 6 (CPSF6) during fibroblast-
Huanyu Yang, Li Zhang, Mengjia Han, Qiongxiao Wu, Chengye Zhang, Qi Xu   +5 more
exaly   +3 more sources

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer [PDF]

Clinical and Translational Medicine
Background N6‐methyladenosine (m6A) and alternative polyadenylation (APA) are common posttranscriptional regulatory mechanisms in eukaryotes. However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear.
Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu   +14 more
doaj   +3 more sources

CPSF6 promotes HIV-1 preintegration complex function [PDF]

Journal of Virology
Cleavage and polyadenylation specificity factor 6 (CPSF6) is part of the cellular cleavage factor I mammalian (CFIm) complex that regulates mRNA processing and polyadenylation.
Evan Chaudhuri, Sooin Jang, Rajasree Chakraborty, Rajalingam Radhakrishnan, Bjarki Arnarson, Prem Prakash, Daphne Cornish, Nicholas Rohlfes, Parmit K. Singh, Jiong Shi, Christopher Aiken, Edward Campbell, Judd Hultquist, Muthukumar Balsubramaniam, Alan N. Engelman, Chandravanu Dash   +15 more
exaly   +4 more sources

CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation

Cell Reports, 2023
Summary: Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration.
Anlong Xu
exaly   +3 more sources

Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

Frontiers in Genetics, 2021
Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Xinglong Shi, Keshuo Ding, Yani Kang
exaly   +3 more sources

HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution [PDF]

mBio
HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Charlotte Luchsinger, Annie Zhi Dai, Hari Yalamanchili, Aiswarya Balakrishnan, Kai-Lieh Huang, Cinzia Bertelli, Bin Cui, Ramon Lorenzo-Redondo, Eric J. Wagner, Felipe Diaz-Griffero   +9 more
doaj   +2 more sources

Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors. [PDF]

MedComm (2020)
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Zhang X, Sun L, Walsham L, Ma Y, Ding D, Wang M, Zhao F, Zhang J, Wang Z, Xu S, Jiang X, Zhou Y, De Clercq E, Pannecouque C, Chen CH, Goldstone DC, Liu X, Dick A, Zhan P.   +18 more
europepmc   +2 more sources

Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles [PDF]

eLife
Viruses rely on host cellular machinery for replication. After entering the nucleus, the HIV genome accumulates in nuclear niches where it undergoes reverse transcription and integrates into neighbouring chromatin, promoting high transcription rates and ...
Chiara Tomasini, Celine Cuche, Selen Ay, Maxence Collard, Bin Cui, Mohammad Rashid, Shaoni Bhattacharjee, Bruno Tello-Rubio, Julian Buchrieser, Charlotte Luchsinger, Cinzia Bertelli, Vladimir Uversky, Felipe Diaz-Griffero, Francesca Di Nunzio   +13 more
doaj   +2 more sources

Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells. [PDF]

PLoS Pathogens
Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV ...
Daphne Cornish, Kathryn A Jackson-Jones, Ted Ling-Hu, Lacy M Simons, William J Cisneros, Edmund Osei Kuffour, Natalie Stegman, Francesca Agnes, Yujin Lee, Ved P Sharma, Paul D Bieniasz, Ramon Lorenzo-Redondo, Judd F Hultquist   +12 more
doaj   +2 more sources

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

MBio, 2020
Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral ...
Wen Li, Parmit K Singh, Gregory A Sowd
exaly   +3 more sources