CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target [PDF]
EBioMedicine, 2017 Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist.
Ibrahim Y Hachim Mbbs +2 more
exaly +6 more sources
MBio, 2020 Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral ...
Wen Li, Parmit K Singh, Alan N Engelman
exaly +5 more sources
The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
doaj +5 more sources
Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration [PDF]
mBioHuman immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration.
Zachary Ingram +12 more
doaj +6 more sources
MBio, 2021 HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.
Zhou Zhong, Jiying Ning, Sooin Jang
exaly +6 more sources
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses. [PDF]
PLoS PathogensAlternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3' untranslated regions (3' UTRs).
Yong Ge +12 more
doaj +4 more sources
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. [PDF]
PLoS Pathogens, 2012 The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with
Amanda J Price +8 more
doaj +5 more sources
Unique Genetic and Epigenetic Alterations in Glioblastoma Long-Term Survivors: Insights From Two Clinical Cases. [PDF]
J Cell Mol MedABSTRACT The biological mechanisms driving the long survival in glioblastoma (GBM). Five‐year long‐term survival (LTS) and 10‐year survival very long‐term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR10‐046 (VLTS) was affected by a giant cell‐GBM, classified as the pedHGG_RTK1a subtype according to the ...
Anghileri E +12 more
europepmc +2 more sources
NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression
Cancer Management and Research, 2020 Bi-Jun Wang,1,* Da-Chao Liu,1,* Qian-Ying Guo,2,* Xiao-Wen Han,2 Xiao-Min Bi,2 Hao Wang,2 Zheng-Sheng Wu,2 Wen-Yong Wu1 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ...
Wang BJ +7 more
doaj +4 more sources
Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs [PDF]
Life Science AlliancePARN regulates poly(A) lengths of pri-miR-29a and pri-miR-1207, which in turn target PARN mRNA. CPSF6 recruits PARN to pri-miRNAs, modulating miRNA levels and cell migration, revealing a dynamic mutual feedback between PARN and specific microRNAs.
Athanasios Kyritsis +14 more
doaj +2 more sources