Results 11 to 20 of about 2,267 (171)

CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target [PDF]

EBioMedicine, 2017
Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist.
Najat Binothman, Ibrahim Y. Hachim, Jean-Jacques Lebrun, Suhad Ali   +3 more
doaj   +4 more sources

Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles [PDF]

eLife
Viruses rely on host cellular machinery for replication. After entering the nucleus, the HIV genome accumulates in nuclear niches where it undergoes reverse transcription and integrates into neighbouring chromatin, promoting high transcription rates and ...
Chiara Tomasini, Celine Cuche, Selen Ay, Maxence Collard, Bin Cui, Mohammad Rashid, Shaoni Bhattacharjee, Bruno Tello-Rubio, Julian Buchrieser, Charlotte Luchsinger, Cinzia Bertelli, Vladimir Uversky, Felipe Diaz-Griffero, Francesca Di Nunzio   +13 more
doaj   +7 more sources

CPSF6-mediated alternative polyadenylation of RUNX1 to regulate silica-induced pulmonary fibrosis progression [PDF]

Respiratory Research
Background Pulmonary fibrosis occurs when myofibroblasts and the extracellular matrix (ECM) excessively accumulate in the lung interstitium. Detailed studies elucidating the role of cleavage and polyadenylation-specific factor 6 (CPSF6) during fibroblast-
Huanyu Yang, Li Zhang, Mengjia Han, Qiongxiao Wu, Chengye Zhang, Qi Xu   +5 more
doaj   +4 more sources

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. [PDF]

PLoS Pathogens, 2012
The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with
Amanda J Price, Adam J Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N KewalRamani, Jason W Chin, Greg J Towers, Leo C James   +8 more
doaj   +7 more sources

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer [PDF]

Clinical and Translational Medicine
Background N6‐methyladenosine (m6A) and alternative polyadenylation (APA) are common posttranscriptional regulatory mechanisms in eukaryotes. However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear.
Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu   +14 more
doaj   +3 more sources

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration [PDF]

mBio
Human immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration.
Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose   +12 more
doaj   +6 more sources

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]

PLoS Pathogens
The early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K Singh, Gregory J Bedwell, Alan N Engelman, Adarsh Dharan, Edward M Campbell   +6 more
doaj   +5 more sources

The functional interplay between TNPO3, CPSF6 and HIV-1 CA [PDF]

, 2014
Lentiviruses can infect postmitotic cells, indicative of a role for the nucleocytoplasmic transport machinery. Genome-wide RNA interference screens identified transportin 3 (TNPO3) that may regulate human immunodeficiency virus type 1 (HIV-1 ...
Oztop, Ilker
core   +7 more sources

Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors. [PDF]

MedComm (2020)
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Zhang X, Sun L, Walsham L, Ma Y, Ding D, Wang M, Zhao F, Zhang J, Wang Z, Xu S, Jiang X, Zhou Y, De Clercq E, Pannecouque C, Chen CH, Goldstone DC, Liu X, Dick A, Zhan P.   +18 more
europepmc   +2 more sources

Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells. [PDF]

PLoS Pathogens
Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV ...
Daphne Cornish, Kathryn A Jackson-Jones, Ted Ling-Hu, Lacy M Simons, William J Cisneros, Edmund Osei Kuffour, Natalie Stegman, Francesca Agnes, Yujin Lee, Ved P Sharma, Paul D Bieniasz, Ramon Lorenzo-Redondo, Judd F Hultquist   +12 more
doaj   +2 more sources