Results 11 to 20 of about 2,100 (181)

CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target [PDF]

EBioMedicine, 2017
Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist.
Najat Binothman, Ibrahim Y. Hachim, Jean-Jacques Lebrun, Suhad Ali   +3 more
doaj   +5 more sources

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration [PDF]

mBio
Human immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration.
Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose   +12 more
doaj   +6 more sources

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]

PLoS Pathogens
The early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K Singh, Gregory J Bedwell, Alan N Engelman, Adarsh Dharan, Edward M Campbell   +6 more
doaj   +5 more sources

In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects. [PDF]

PLoS Pathogens, 2014
The host protein CPSF6 possesses a domain that can interact with the HIV-1 capsid (CA) protein. CPSF6 has been implicated in regulating HIV-1 nuclear entry. However, its functional significance for HIV-1 replication has yet to be firmly established. Here
Matthew S Henning, Brittany N Dubose, Mallori J Burse, Christopher Aiken, Masahiro Yamashita   +4 more
doaj   +2 more sources

CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Background Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini.
Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, Tao Zhu, Jielin Sun, Xiaodong Zhao   +11 more
doaj   +3 more sources

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

Scientific Reports, 2023
The early events of HIV-1 infection involve the transport of the viral core into the nucleus. This event triggers the translocation of CPSF6 from paraspeckles into nuclear speckles forming puncta-like structures.
Charlotte Luchsinger, KyeongEun Lee, Gonzalo A. Mardones, Vineet N. KewalRamani, Felipe Diaz-Griffero   +4 more
doaj   +2 more sources

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. [PDF]

PLoS Pathogens, 2012
The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with
Amanda J Price, Adam J Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N KewalRamani, Jason W Chin, Greg J Towers, Leo C James   +8 more
doaj   +5 more sources

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

mBio, 2020
HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.
Zhou Zhong, Jiying Ning, Emerson A. Boggs, Sooin Jang, Callen Wallace, Cheryl Telmer, Marcel P. Bruchez, Jinwoo Ahn, Alan N. Engelman, Peijun Zhang, Simon C. Watkins, Zandrea Ambrose   +11 more
openaire   +6 more sources

HIV-1 uncoating location dictates sites of integration [PDF]

Nature Communications
HIV-1 cores enter the nucleus and undergo capsid disassembly (uncoating) near their integration site. Although most viral cores are localized to nuclear speckles (NSs), the spatial relationship between the uncoating site and integration site remains ...
Ryan C. Burdick, Sean C. Patro, Ellie Bare, Rokeya Siddiqui, Krista A. Delviks-Frankenberry, Olga A. Nikolaitchik, Stephen H. Hughes, Xiaolin Wu, Wei-Shau Hu, Vinay K. Pathak   +9 more
doaj   +2 more sources

Unique Genetic and Epigenetic Alterations in Glioblastoma Long-Term Survivors: Insights From Two Clinical Cases. [PDF]

J Cell Mol Med
ABSTRACT The biological mechanisms driving the long survival in glioblastoma (GBM). Five‐year long‐term survival (LTS) and 10‐year survival very long‐term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR10‐046 (VLTS) was affected by a giant cell‐GBM, classified as the pedHGG_RTK1a subtype according to the ...
Anghileri E, Miele E, Patrizi S, Barresi S, Lazzarini E, Maddaloni L, Patanè M, Pedace L, Paterra R, Silvani A, Locatelli F, Indraccolo S, Pollo B.   +12 more
europepmc   +2 more sources