Results 41 to 50 of about 2,267 (171)
The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6 [PDF]
Retrovirology, 2013 Abstract Background Expression of the cellular karyopherin TNPO3/transportin-SR2/Tnp3 is necessary for HIV-1 infection. Depletion of TNPO3 expression in mammalian cells inhibits HIV-1 infection after reverse transcription but prior to integration.
Fricke, Thomas +7 more
openaire +2 more sources
RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer
World Journal of Gastrointestinal Oncology, 2023 Pancreatic cancer (PanCa) presents a catastrophic disease with poor overall survival at advanced stages, with immediate requirement of new and effective treatment options. Besides genetic mutations, epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target. Mechanisms beneath the deoxyribonucleic
Wang, Xue-Jun +4 more
openaire +2 more sources
iScience, 2022 Summary: The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207). We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection.
Anastasia Selyutina +8 more
doaj +1 more source
Viruses, 2022 The core of HIV-1 viruses bearing the capsid change N74D (HIV-1-N74D) do not bind the human protein CPSF6. In primary human CD4+ T cells, HIV-1-N74D viruses exhibit an infectivity defect when compared to wild-type.
Anastasia Selyutina +7 more
doaj +1 more source
Retrovirology, 2020 Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import
Linlin Xie +11 more
doaj +1 more source
Mutation in cpsf6/CFIm68 (Cleavage and Polyadenylation Specificity Factor Subunit 6) causes short 3'UTRs and disturbs gene expression in developing embryos, as revealed by an analysis of primordial germ cell migration using the medaka mutant naruto. [PDF]
PLoS ONE, 2017 Our previous studies analyzing medaka mutants defective in primordial germ cell (PGC) migration identified cxcr4b and cxcr7, which are both receptors of the chemokine sdf1/cxcl12, as key regulators of PGC migration.
Takao Sasado +3 more
doaj +1 more source
HIV Capsid and Integration Targeting
Viruses, 2021 Integration of retroviral reverse transcripts into the chromosomes of the cells that they infect is required for efficient viral gene expression and the inheritance of viral genomes to daughter cells.
Alan N. Engelman
doaj +1 more source
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration.
PLoS Pathogens, 2021 The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment the core is released into the cytoplasm, it interacts with a range of cellular factors that, ultimately, direct the pre-integration complex to the integration ...
Anabel Guedán +5 more
doaj +1 more source
Cytopmasic CPSF6 and Cyclophilin A Modulate HIV-1 Trafficking [PDF]
, 2020 Human immunodeficiency virus type 1 (HIV-1) capsid binds to multiple host cell proteins after entry into a cell, including cyclophilin A (CypA) and cleavage and polyadenylation specificity factor 6 (CPSF6), which is expressed predominantly in the nucleus.
Zhong, Zhou
core
Frontiers in Oncology, 2022 Retinoic acid receptor gamma (RARG) gene rearrangement has been reported in several acute myeloid leukemia (AML) patients. They resemble classical acute promyelocytic leukemia (APL) patients in clinical features, morphology, and immunophenotype but do ...
Junmei Zhao +7 more
doaj +1 more source