Results 41 to 50 of about 2,100 (181)
The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6 [PDF]
Retrovirology, 2013 Abstract Background Expression of the cellular karyopherin TNPO3/transportin-SR2/Tnp3 is necessary for HIV-1 infection. Depletion of TNPO3 expression in mammalian cells inhibits HIV-1 infection after reverse transcription but prior to integration.
Fricke, Thomas +7 more
openaire +2 more sources
RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer
World Journal of Gastrointestinal Oncology, 2023 Pancreatic cancer (PanCa) presents a catastrophic disease with poor overall survival at advanced stages, with immediate requirement of new and effective treatment options. Besides genetic mutations, epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target. Mechanisms beneath the deoxyribonucleic
Wang, Xue-Jun +4 more
openaire +2 more sources
iScience, 2022 Summary: The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207). We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection.
Anastasia Selyutina +8 more
doaj +1 more source
Block-and-Lock Approaches for HIV Cure: Mechanistic Insights, Challenges, and Emerging Role of CPSF6. [PDF]
Int J Mol SciThe block-and-lock strategy aims to achieve a functional cure for human immunodeficiency virus type 1 (HIV-1) infection by enforcing durable, drug-independent silencing of proviral transcription. Several latency-promoting agents have been described that effectively limit viral reactivation in vitro or in animal models.
Tolomeo M, Cascio A.
europepmc +2 more sources
Knockdown of CPSF6 impairs circadian temperature compensation.
, 2023 (A) Circadian free-running period of U-2 OS cells lengthens upon shRNA-mediated CPSF6 knockdown (red) in comparison with control cells (blue), as accessed by a Bmal1-luciferase reporter construct. Raw time series data have been normalized by its baseline
Stella Koutsouli (16462758) +10 more
core +1 more source
HIV-1 CA, CPSF6 and SC35 staining during infection.
, 2021 HeLa cells were synchronously infected with equal RT units of WT, A14C/E45C, E180C or M68C/E212C VLP and fixed at 16hpi. Cells were incubated with primary antibodies against HIV-1 CA and CPSF6 (A) or CPSF6 and SC35 (B) followed by specific secondary ...
Kate N. Bishop (11457941) +5 more
core +1 more source
Viruses, 2022 The core of HIV-1 viruses bearing the capsid change N74D (HIV-1-N74D) do not bind the human protein CPSF6. In primary human CD4+ T cells, HIV-1-N74D viruses exhibit an infectivity defect when compared to wild-type.
Anastasia Selyutina +7 more
doaj +1 more source
Retrovirology, 2020 Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import
Linlin Xie +11 more
doaj +1 more source
Mutation in cpsf6/CFIm68 (Cleavage and Polyadenylation Specificity Factor Subunit 6) causes short 3'UTRs and disturbs gene expression in developing embryos, as revealed by an analysis of primordial germ cell migration using the medaka mutant naruto. [PDF]
PLoS ONE, 2017 Our previous studies analyzing medaka mutants defective in primordial germ cell (PGC) migration identified cxcr4b and cxcr7, which are both receptors of the chemokine sdf1/cxcl12, as key regulators of PGC migration.
Takao Sasado +3 more
doaj +1 more source
HIV Capsid and Integration Targeting
Viruses, 2021 Integration of retroviral reverse transcripts into the chromosomes of the cells that they infect is required for efficient viral gene expression and the inheritance of viral genomes to daughter cells.
Alan N. Engelman
doaj +1 more source