Results 61 to 70 of about 2,267 (171)
The Impact of CPSF6 on the Innate Immune Response to HIV Infection [PDF]
, 2022 With no current vaccine for Human Immunodeficiency Virus (HIV), it is crucial to study what factors influence how HIV infects host cells to develop new strategies and therapies to combat this pandemic.
Taukolo, Kenith, Taukolo, Kenith, \u2723
core
Cancer Science, Volume 117, Issue 11, Page 3132-3145, November 2026.Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu +6 more
wiley +1 more source
Proteins showing a significantly altered abundance in wild-type and CPSF6 knockdown cells at 37°C.
, 2023 Information about all 1,683 peptides showing a significantly different abundance after CPSF6 knockdown at 37°C is deposited in the table. Column A depicts the corresponding gene symbol.
Stella Koutsouli (16462758) +10 more
core +1 more source
Nature Communications, 2020 Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially ...
Ashwanth C. Francis +10 more
doaj +1 more source
A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]
Blood Advances, 2018 Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Miller, Christopher A. +13 more
openaire +4 more sources
Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen +8 more
wiley +1 more source
Knockdown of CPSF6 impairs circadian temperature compensation.
, 2023 (A) Circadian free-running period of U-2 OS cells lengthens upon shRNA-mediated CPSF6 knockdown (red) in comparison with control cells (blue), as accessed by a Bmal1-luciferase reporter construct. Raw time series data have been normalized by its baseline
Stella Koutsouli (16462758) +10 more
core +1 more source
PLoS Pathogens, 2014 The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands.
Amanda J Price +8 more
doaj +1 more source
Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. [PDF]
PLoS Pathogens, 2013 Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide crucial functions for lentiviral nuclear entry and integration.
Kenneth A Matreyek +3 more
doaj +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, Volume 59, Issue 9, September 2026.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source