Results 71 to 80 of about 1,827 (136)

Emerging Roles of Biomolecular Condensates in Pre‐mRNA 3′ End Processing

WIREs RNA, Volume 16, Issue 4, July/August 2025.
Pre‐mRNA 3′ end processing factors can self‐assemble into biomolecular condensates that fine‐tune pre‐mRNA cleavage and polyadenylation, and their misregulation underlies disease. Nuclear speckles and histone locus bodies spatially compartmentalize distinct 3′ end reactions to ensure efficient gene expression control.
Yoseop Yoon, Liang Liu, Cailyx Quan, Yongsheng Shi   +3 more
wiley   +1 more source

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

Journal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.
ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang, Ben J. Hayes, Russell E. Lyons, Imtiaz A. S. Randhawa, John B. Gaughan, Nguyen X. Trach, David M. McNeill   +6 more
wiley   +1 more source

Phenotypic Characterization of Replication‐Impaired Lenacapavir‐Resistant HIV Clinical Isolates

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Lenacapavir (LEN) is a potent, first‐in‐class long‐acting HIV‐1 capsid (CA) inhibitor, approved for treatment of people with multi‐drug resistant HIV in combination with other antiretrovirals. In clinical studies with LEN, the CA resistance‐associated mutations (RAMs) M66I, Q67H/K/N, K70H/N/R/S, N74D/H/K, A105S/T, and T107A/C/N/S were observed.
Sally Demirdjian, Vidula Naik, Nicolas Margot, Brie Falkard, Christian Callebaut   +4 more
wiley   +1 more source

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR‐615‐3p‐PICK1 interaction

BioFactors, Volume 51, Issue 1, January/February 2025.
Vimentin affects the miR‐615‐3p‐PICK1 axis via APA, highlighting its role in cancer progression in TNBC. The findings show the interplay between VIM, miR‐615‐3p, and PICK1 and open new avenues for targeted cancer therapy. Abstract Breast cancer continues to be a major health issue for women worldwide, with vimentin (VIM) identified as a crucial factor ...
Xinyan Jia, Lujing Shao, Hong Quan, Zhixian Zhong, Chunyan Dong   +4 more
wiley   +1 more source

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.
N6‐methyladenosine (m6A) modification, a prevalent and reversible epigenetic modification in eukaryotic mRNA, has emerged as a crucial regulator in various biological processes. Recent studies have shed light on the significant role of m6A modification in female reproductive development and its related diseases.
Xiangrong Cui, Huihui Li, Xia Huang, Tingting Xue, Shu Wang, Xinyu Zhu, Xuan Jing   +6 more
wiley   +1 more source

Reading m6A marks in mRNA: A potent mechanism of gene regulation in plants

Journal of Integrative Plant Biology, Volume 66, Issue 12, Page 2586-2599, December 2024.
This review examines N6‐methyladenosine (m6 A) metabolism, including how m6A readers, writers, and erasers recognize and interpret m6A modification on mRNAs; how they regulate the stability, splicing, transport, and translation of mRNAs; and how they function in the response of plants to developmental and environmental signals.
Thi Kim Hang Nguyen, Hunseung Kang
wiley   +1 more source

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

eLife, 2014
The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined reverse-transcription- and pre-integration-complexes (RTC, PIC) with various host and viral proteins implicated.
Ke Peng, Walter Muranyi, Bärbel Glass, Vibor Laketa, Stephen R Yant, Luong Tsai, Tomas Cihlar, Barbara Müller, Hans-Georg Kräusslich   +8 more
doaj   +1 more source

Additional file 2 of CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression

, 2021
Additional file 2 Supplementary Table S1. Clinicopathologic correlation of CPSF6 expression in HCCs. The expression level of CPSF6 protein was detected by immunohistochemistry.
Tan, Sheng, Zhang, Ming, Xinglong Shi, Keshuo Ding, Zhao, Qiang, Qianying Guo, Wang, Hao, Zhengsheng Wu, Kang, Yani, Zhu, Tao, Jielin Sun, Xiaodong Zhao   +11 more
openaire   +1 more source

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.

PLoS Genetics, 2018
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs.
Seth D Kasowitz, Jun Ma, Stephen J Anderson, N Adrian Leu, Yang Xu, Brian D Gregory, Richard M Schultz, P Jeremy Wang   +7 more
doaj   +1 more source