Results 71 to 80 of about 2,267 (171)
PROTEOMICS, Volume 26, Issue 8, Page 69-80, August 2026.ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim +4 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 26, 10 July 2026.This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen +7 more
wiley +1 more source
Interactions in the HIV-1 CAN:CPSF6313–327 complex.
, 2012 (A–D) Detailed views of the HIV-1 CAN:CPSF6313–327 interface. HIV-1 CAN is shown as grey cartoon, HIV-1 residues that bind CPSF6 are in green and CPSF6313–327 in yellow.
Vineet N. KewalRamani (138643) +8 more
core +1 more source
Journal of Pineal Research, Volume 78, Issue 4, July 2026.ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh +3 more
wiley +1 more source
CPSF6 binds diverse lentiviral capsids.
, 2012 Isothermal titration calorimetry (ITC) of CPSF6313–327 against CAN domains of lentiviral capsids. CPSF6313–327 binding to HIV-1 is specific (A), being abolished by CA mutation N74D (B). CPSF6313–327 also binds to diverse primate lentiviral capsids, HIV-2,
Vineet N. KewalRamani (138643) +8 more
core +1 more source
, 2023 (A) NCOM temperature coefficient Q10 in CPSF6 knockdown versus wild-type cells. Significantly differential responses in PAS selection (i.e., NCOM shifts) upon temperature changes between wild-type and CPSF6 knockdown cells are depicted by orange dots. (B)
Stella Koutsouli (16462758) +10 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri +15 more
wiley +1 more source
Crystal structure of HIV-1 CAN in complex with CPSF6313–327.
, 2012 (A) Crystal structure of the HIV-1 CAN:CPSF6313–327 complex. HIV-1 CAN is shown as cartoon representation and CPSF6 as sticks. Secondary structure elements in HIV-1 CAN are labeled.
Vineet N. KewalRamani (138643) +8 more
core +1 more source
Liquid–Liquid Phase Separation in Viral Infection and Immunology
MedComm, Volume 7, Issue 4, April 2026.LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu +5 more
wiley +1 more source
, 2021 Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Jielin Sun (123338) +6 more
core +1 more source