Results 71 to 80 of about 2,100 (181)
Journal of Pineal Research, Volume 78, Issue 4, July 2026.ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh +3 more
wiley +1 more source
A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]
Blood Advances, 2018 Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Miller, Christopher A. +13 more
openaire +4 more sources
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri +15 more
wiley +1 more source
PLoS Pathogens, 2014 The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands.
Amanda J Price +8 more
doaj +1 more source
, 2021 Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Jielin Sun (123338) +6 more
core +1 more source
Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. [PDF]
PLoS Pathogens, 2013 Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide crucial functions for lentiviral nuclear entry and integration.
Kenneth A Matreyek +3 more
doaj +1 more source
Liquid–Liquid Phase Separation in Viral Infection and Immunology
MedComm, Volume 7, Issue 4, April 2026.LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu +5 more
wiley +1 more source
HIV-1 CA, CPSF6 and SC35 staining during infection with WT and hyper-stable mutant VLP.
, 2021 HeLa cells were synchronously infected with equal RT units of WT, A14C/E45C, E180C or M68C/E212C VLP and fixed at 16hpi. Cells were incubated with primary antibodies against HIV-1 CA, CPSF6 and SC35 followed by specific secondary antibodies conjugated to
Kate N. Bishop (11457941) +5 more
core +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
Stem Cell Reports, 2023 Summary: Alternative polyadenylation (APA) gives rise to transcripts with distinct 3′ untranslated regions (3′ UTRs), thereby affecting the fate of mRNAs.
Na Li +8 more
doaj +1 more source