Results 91 to 100 of about 2,100 (181)
Mutations that reduce CA binding to CPSF6 rescue T54A.
, 2014 (A) HeLa cells stably transduced with the control LPCX vector or one overexpressing CPSF6-358 were infected with VSV-G-pseudotyped GFP reporter viruses.
Matthew S. Henning (507871) +4 more
core +1 more source
, 2021 Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Jielin Sun (123338) +6 more
core +1 more source
Phenotypic Characterization of Replication‐Impaired Lenacapavir‐Resistant HIV Clinical Isolates
Journal of Medical Virology, Volume 97, Issue 4, April 2025.ABSTRACT Lenacapavir (LEN) is a potent, first‐in‐class long‐acting HIV‐1 capsid (CA) inhibitor, approved for treatment of people with multi‐drug resistant HIV in combination with other antiretrovirals. In clinical studies with LEN, the CA resistance‐associated mutations (RAMs) M66I, Q67H/K/N, K70H/N/R/S, N74D/H/K, A105S/T, and T107A/C/N/S were observed.
Sally Demirdjian +4 more
wiley +1 more source
Circadian free-running period dose dependently lengthens upon CPSF6 and NUDT21 knockdown.
, 2023 (A) Raw (first column) and detrended (second column) Bmal1-luciferase expression in human control (blue) and CPSF6-depleted (red) U-2 OS cells, using 3 different shRNA constructs.
Stella Koutsouli (16462758) +10 more
core +1 more source
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
BioFactors, Volume 51, Issue 1, January/February 2025.Vimentin affects the miR‐615‐3p‐PICK1 axis via APA, highlighting its role in cancer progression in TNBC. The findings show the interplay between VIM, miR‐615‐3p, and PICK1 and open new avenues for targeted cancer therapy. Abstract Breast cancer continues to be a major health issue for women worldwide, with vimentin (VIM) identified as a crucial factor ...
Xinyan Jia +4 more
wiley +1 more source
Number of embryos injected with the cpsf6 mRNA.
, 2017 Number of embryos injected with the cpsf6 mRNA.
Takao Sasado (24195) +3 more
core +1 more source
, 2021 Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Jielin Sun (123338) +6 more
core +1 more source
, 2021 Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Jielin Sun (123338) +6 more
core +1 more source
eLife, 2014 The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined reverse-transcription- and pre-integration-complexes (RTC, PIC) with various host and viral proteins implicated.
Ke Peng +8 more
doaj +1 more source