Results 111 to 120 of about 1,827 (136)

Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy. [PDF]

Int J Biol Sci
Sim DY, Lee HJ, Ahn CH, Park J, Park SY, Kil BJ, Shim BS, Kim B, Kim SH.   +8 more
europepmc   +1 more source

The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid. [PDF]

PLoS Pathog
Hong J, Deshpande A, Thakare Y, Simonovsky L, Douglas AW, Guinness CM, Rotem-Dai N, Kortyna ML, Klarhof JO, Shi J, James LC, Boecking T, Francis AC, Rousso I, Aiken C.   +14 more
europepmc   +1 more source

Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3. [PDF]

Nat Commun
Zhou Q, Sagmeister T, Hutten S, Bourgeois B, Pavkov-Keller T, Dormann D, Madl T.   +6 more
europepmc   +1 more source

Κλωνοποίηση και αποτίμηση της βιολογικής σημασίας του παράγοντα πολυαδενυλίωσης CPSF6

, 2016
openaire   +1 more source

HIV-1 and Its Strategy for Hiding Viral cDNA from STING-Mediated Innate Immunity. [PDF]

Int J Mol Sci
Mashkovskaia A, Agapkina Y, Oretskaya T, Gottikh M, Anisenko A.   +4 more
europepmc   +1 more source

The identification of a novel interaction site for the human immunodeficiency virus capsid on nucleoporin 153. [PDF]

J Gen Virol
Li S, Lund-Andersen P, Wang SH, Ytreberg FM, Naik MT, Patel JS, Rowley PA.   +6 more
europepmc   +1 more source

Functional roles and mechanisms of circRNA-protein interactions in cancer progression and tumor immune regulation. [PDF]

Front Immunol
Yang L, Li C, Jiang X, Yuan Y, Li C, Zhou Q, Wang Q, Xiong J.   +7 more
europepmc   +1 more source

Correlative In Situ Cryo-ET Reveals Cellular and Viral Remodeling Associated with Selective HIV-1 Core Nuclear Import

Hou Z, Shen Y, Fronik S, Shen J, Shi J, Xu J, Chen L, Hardenbrook N, Thompson C, Neumann S, Engelman AN, Aiken C, Zhang P.   +12 more
europepmc   +1 more source

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid [PDF]

Journal of Virology, 2018
ABSTRACT Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration complexes. Truncation of the protein at its C-terminal nuclear-targeting arginine/serine-rich (RS) domain produces a protein, CPSF6-358 ...
Jiying Ning, Zhou Zhong, Gemma Harris
exaly   +4 more sources

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration [PDF]

Cell Host and Microbe, 2018
HIV-1 integration into the host genome favors actively transcribed genes. Prior work indicated that the nuclear periphery provides the architectural basis for integration site selection, with viral capsid-binding host cofactor CPSF6 and viral integrase-binding cofactor LEDGF/p75 contributing to selection of individual sites.
Vasudevan Achuthan, Alan N Engelman, Maritza Puray-Chavez   +2 more
exaly   +3 more sources