Results 111 to 120 of about 2,267 (171)

CPSF6\u27s Nuclear Localization Signal Mediates HIV-1 Intranuclear Events Following Nuclear Import

The early stages of the HIV-1 lifecycle include the trafficking of the viral capsid into the nucleus of infected cells. The viral capsid, which encloses the viral genome and accessory proteins required for reverse transcription (RT) and integration ...
Rohlfes, Nick
core  

The Role of Cleavage and Polyadenylation Spcific Factor 6 (CPSF6) in Hematopoiesis

Cleavage and polyadenylation specific factor 6 (Cpsf6) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis ...
Ye, Fengxi
core  

Primate-specific SSX1 is required for CPSF6-dependent spermatocyte transcription and human fertility

Abstract Genetic variation is a major cause of male infertility, and defining the underlying mechanisms is essential for developing effective interventions. SSX1 is a primate specific gene whose deficiency has been linked to sperm malformations in humans and cynomolgus monkeys, yet ...
Rong Hua, Qingsong Xie, Xuan Sha, Meizhou Liu, Guotong Li, Xun Xia, Yuqian Li, Yudie Guo, Mengting Xie, Chuan Xu, Hao Geng, Xiaojin He, Y Cao, Huan Wu   +13 more
openaire   +1 more source

Cleavage and polyadenylation specific factor 6 (CPSF6); cyclophilin A (CYPA; PPIA) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

, 2019
Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor 5 (CPSF5) and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA).
Parmit K Singh (8128404), Valerie E Pye (8128395), Amanda M Dudek (8128401), Peter Cherepanov (369), Sooin Jang (172363), Nicola J Cook (8128392), Gregory J Bedwell (8128398), Alan N Engelman (8128407)   +7 more
core  

Capsid stabilization reprograms the nuclear fate of the HIV genome. [PDF]

Sci Adv
Mourer T, Harastani M, Cuche C, Perez-Lopez JI, Tornambe S, Tachon S, Corre G, Maristany MJ, Tinevez JY, Gazi A, Poletti V, Collepardo-Guevara R, Sartori-Rupp A, Di Nunzio F.   +13 more
europepmc   +1 more source

3'UTR Mapping Reveals Alternative Polyadenylation in Right Ventricular Failure. [PDF]

Circ Res
Neupane R, Natarajan K, Suarez EE, Pownall HJ, Huang KL, Wagner EJ, Verma AK, Majji R, Yalamanchili HK, Guha A, Thandavarayan RA.   +10 more
europepmc   +1 more source

Alternative polyadenylation links RNA processing to iron metabolism in human erythropoiesis. [PDF]

Nucleic Acids Res
Yu S, Zeng X, Chen J, Lou Z, Jiang T, Ou Y, Du P, Rao J, Dai X, Gong M, Xu J, Yi P, Wang F, Wang X, Zhu Y.   +14 more
europepmc   +1 more source

Mis-localized nucleoporin POM121C potently inhibits nuclear entry of HIV-1 but leads to the outgrowth of viral escape mutants. [PDF]

J Virol
Saito H, Miyagi E, Kao S, Dai A, Rashid MM, Yang DT, Chakraborty R, Dash C, Gronenborn AM, Diaz-Griffero F, Strebel K.   +10 more
europepmc   +1 more source

A geometric criterion links HIV-1 capsid topography to its biophysical properties and function. [PDF]

Nat Commun
Li W, Peeples CA, Rey JS, Perilla JR, Twarock R.   +4 more
europepmc   +1 more source