Results 111 to 120 of about 2,100 (181)

Disruption of CPSF6 enhances cellular permissivity to HIV-1 infection through alternative polyadenylation

Abstract Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response1. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV-1 cores to regulate trafficking2, nuclear import3-5, uncoating6, and integration ...
Judd Hultquist, Daphne Cornish, Kathryn Jackson-Jones, Ted Ling-Hu, Lacy Simons, William Cisneros, Edmund Kuffour, Francesca Agnes, Yujin Lee, Paul Bieniasz, Ramon Lorenzo-Redondo   +10 more
openaire   +2 more sources

HIV-1 CTL escape variants invariably preserve CA-CPSF6 interactions in vivo during their evasion from the restrictive action of CPSF6.

, 2014
(A) HeLa cells were infected with VSV-G-pseudotyped GFP reporter viruses in the presence or absence of aphidicolin (Aph).
Matthew S. Henning (507871), Mallori J. Burse (507873), Christopher Aiken (47132), Brittany N. Dubose (507872), Masahiro Yamashita (12303)   +4 more
core   +1 more source

The CPSF6 interface is conserved in HIV-1, HIV-2, SIVmac CA^N.

, 2012
(A) The CPSF6-binding interface is highly conserved within HIV-1 viruses. The ConSurf Server [42], [43] was used to map ∼100 unique HIV-1 CAN sequences onto the HIV-1 CAN:CPSF6313–327 structure.
Vineet N. KewalRamani (138643), Leo C. James (138654), Torsten Schaller (138630), Tom Elliott (138636), Jason W. Chin (138646), Adam J. Fletcher (138624), KyeongEun Lee (138641), Greg J. Towers (138650), Amanda J. Price (138619)   +8 more
core   +1 more source

Étude structurale et fonctionnelle de CPSF6 dans l'import nucléaire du VIH-1

L'interaction du complexe CPSF5/CPSF6 avec les complexes CA du VIH-1 a été étudiée par cristallographie et cryoEM. Nos résultats montrent que CPSF5 forme un complexe étroit avec CPSF6 in vitro, ce qui peut expliquer le co-recrutement du CPSF5 avec le ...
Zhu, Rui
core  

Drug PF-3450074 binds to part of the CPSF6-binding interface in HIV-1 CA^N.

, 2012
(A) Superposition of HIV-1 CAN:PF-3450074 structure (pdb: 2XDE) [38] on HIV-1 CAN:CPSF6313–327 using secondary structure matching of the HIV-1 CAN domains. Drug PF-3450074 is shown in cyan, CPSF6313–327 in yellow.
Vineet N. KewalRamani (138643), Leo C. James (138654), Torsten Schaller (138630), Tom Elliott (138636), Jason W. Chin (138646), Adam J. Fletcher (138624), KyeongEun Lee (138641), Greg J. Towers (138650), Amanda J. Price (138619)   +8 more
core   +1 more source

Cleavage and Polyadenylation Specific Factor 6 (CPSF6): A possible protein mediator for CARM1 and pre-MRNA splicing

, 2008
1 p. (abstract only). YOU CANNOT OPEN THE COMPLETE PAPER. It is not available to the public, in accordance with the author's wishes.Coactivated associated methyltransferase 1 (CARM1), an enzyme that regulates cellular processes via arginine methylation,
Ang, SiangYun
core  

The mechanism by which CPSF6 regulates antiviral immune responses through APA.

CPSF6 is a negative regulator of IFN-I signalling in resting cells, and the protein abundance of CPSF6 decreases upon viral infection. With the decrease in CPSF6 expression, proximal PASs are preferentially selected in immune-related genes, resulting in ...
Rong Chen (29176), Jingrong Huang (12354340), Yonggui Fu (109340), Xin Ou (1872004), Anlong Xu (24151), Yi Lin (49406), Tao Ling (704718), Xiaohui Rong (3354842), Fengyi Zhou (9034415), Chuanjian Lu (534232), Shaochun Yuan (7397426), Yong Ge (816832), Youxiang Cheng (18071604)   +12 more
core   +1 more source

Binding of HIV-1 hexamer to CPSF6, NUP153, PF74 and BI-2.

, 2014
(A) ITC binding isotherms of HIV-1 hexamer titrated into different ligands in either the presence or absence of DTT. For both CPSF6 and NUP153, a peptide corresponding to residues 313–327 or 1407–1423 respectively was used.
David A. Jacques (652049), Upul D. Halambage (652052), Leo C. James (138654), Christopher Aiken (47132), Jason W. Chin (138646), Adam J. Fletcher (138624), William A. McEwan (652050), Amanda J. Price (138619), Sebastian Essig (652051)   +8 more
core   +1 more source

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia

Nature Communications
Acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) fusions, which exhibits clinical features resembling acute promyelocytic leukemia (APL), has been identified as a new subtype with poor clinical outcomes.
Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu   +11 more
doaj   +1 more source

CPSF6\u27s Nuclear Localization Signal Mediates HIV-1 Intranuclear Events Following Nuclear Import

The early stages of the HIV-1 lifecycle include the trafficking of the viral capsid into the nucleus of infected cells. The viral capsid, which encloses the viral genome and accessory proteins required for reverse transcription (RT) and integration ...
Rohlfes, Nick
core