Results 101 to 110 of about 2,100 (181)
Endogenous CPSF6 restricts cell cycle-dependent HIV-1 CA mutants.
, 2014 (A, B) HeLa cells transfected with either non-targeting siRNA or siRNA targeting CPSF6 were infected with RT-normalized VSV-G-pseudotyped GFP reporter viruses.
Matthew S. Henning (507871) +4 more
core +1 more source
Interactions in the HIV-1 CAN:CPSF6313–327 complex.
, 2012 (A–D) Detailed views of the HIV-1 CAN:CPSF6313–327 interface. HIV-1 CAN is shown as grey cartoon, HIV-1 residues that bind CPSF6 are in green and CPSF6313–327 in yellow.
Vineet N. KewalRamani (138643) +8 more
core +1 more source
, 2023 Information about all 678 peptides showing a significantly differential temperature response in LFQ intensities (i.e., peptide abundance) between wild-type (WT) and CPSF6-depleted (KD) cells. Column A depicts the corresponding gene symbols.
Stella Koutsouli (16462758) +10 more
core +1 more source
PLoS Genetics, 2018 The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs.
Seth D Kasowitz +7 more
doaj +1 more source
Crystal structure of HIV-1 CAN in complex with CPSF6313–327.
, 2012 (A) Crystal structure of the HIV-1 CAN:CPSF6313–327 complex. HIV-1 CAN is shown as cartoon representation and CPSF6 as sticks. Secondary structure elements in HIV-1 CAN are labeled.
Vineet N. KewalRamani (138643) +8 more
core +1 more source
Cell Reports, 2015 Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an imaging approach, ViewHIV, which allows evaluation of early HIV-1 replication intermediates ...
Christopher R. Chin +7 more
doaj +1 more source
Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle
Summary Viruses rely on host cellular machinery for replication. After entering the nucleus, the HIV genome accumulates in nuclear niches where it undergoes reverse transcription and integrates into neighboring chromatin, promoting high transcription rates and new virus progeny.
Celine Cuche +12 more
openaire +1 more source
The Impact of CPSF6 on the Innate Immune Response to HIV Infection
, 2022 With no current vaccine for Human Immunodeficiency Virus (HIV), it is crucial to study what factors influence how HIV infects host cells to develop new strategies and therapies to combat this pandemic.
Taukolo, Kenith, Taukolo, Kenith, \u2723
core
The CPSF6-binding interface is accessible and highly conserved in HIV-1 virions.
, 2012 (A) Model of CPSF6313–327 binding to HIV-1 CA hexamer. The hexamer structure was derived from pdb: 3H47 [15] by generating symmetry-related copies in PyMOL.
Vineet N. KewalRamani (138643) +8 more
core +1 more source
The mRNA expression of CPSF6 is regulated by virus-induced miR-377-3p.
(A-G) The relative mRNA expression of CPSF6 in peripheral blood-T cells from ITP (A), PBMCs from asthma (B), monocytes from patients with RA (C), CD3+ T cells from patients with SLE (D), epidermis from psoriasis (E), CD4+ splenocytes from CLP-induced ...
Rong Chen (29176) +12 more
core +1 more source