Results 101 to 110 of about 2,267 (171)

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

Cell Reports, 2015
Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an imaging approach, ViewHIV, which allows evaluation of early HIV-1 replication intermediates ...
Christopher R. Chin, Jill M. Perreira, George Savidis, Jocelyn M. Portmann, Aaron M. Aker, Eric M. Feeley, Miles C. Smith, Abraham L. Brass   +7 more
doaj   +1 more source

Structural and functional study of CPSF6 in HIV-1 nuclear import

Étude structurale et fonctionnelle de CPSF6 dans l'import nucléaire du VIH-1 L'interaction du complexe CPSF5/CPSF6 avec les complexes CA du VIH-1 a été étudiée par cristallographie et cryoEM. Nos résultats montrent que CPSF5 forme un complexe étroit avec CPSF6 in vitro, ce qui peut expliquer le co-recrutement du CPSF5 avec le CPSF6 par ...
openaire   +2 more sources

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.

PLoS Genetics, 2018
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs.
Seth D Kasowitz, Jun Ma, Stephen J Anderson, N Adrian Leu, Yang Xu, Brian D Gregory, Richard M Schultz, P Jeremy Wang   +7 more
doaj   +1 more source

Étude structurale et fonctionnelle de CPSF6 dans l'import nucléaire du VIH-1

The interaction of the CPSF5/CPSF6 complex with HIV-1 CA complexes was studied using X-ray crystallography and cryo-EM. Our results show that CPSF5 forms a tight complex with CPSF6 in vitro, which can explain the co-recruitment of CPSF5 with CPSF6 by HIV-
Zhu, Rui
core   +4 more sources

The mRNA expression of CPSF6 is regulated by virus-induced miR-377-3p.

(A-G) The relative mRNA expression of CPSF6 in peripheral blood-T cells from ITP (A), PBMCs from asthma (B), monocytes from patients with RA (C), CD3+ T cells from patients with SLE (D), epidermis from psoriasis (E), CD4+ splenocytes from CLP-induced ...
Rong Chen (29176), Jingrong Huang (12354340), Yonggui Fu (109340), Xin Ou (1872004), Anlong Xu (24151), Yi Lin (49406), Tao Ling (704718), Xiaohui Rong (3354842), Fengyi Zhou (9034415), Chuanjian Lu (534232), Shaochun Yuan (7397426), Yong Ge (816832), Youxiang Cheng (18071604)   +12 more
core   +1 more source

Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease

Genome Medicine
Background Circular RNAs (circRNAs) are highly stable regulators, often accumulated in mammalian brains and thought to serve as “memory molecules” that govern the long process of aging.
Feng Wang, Yangping Li, Huifeng Shen, Paula Martinez-Feduchi, Xingyu Ji, Peng Teng, Siddharth Krishnakumar, Jian Hu, Li Chen, Yue Feng, Bing Yao   +10 more
doaj   +1 more source

Disruption of CPSF6 enhances cellular permissivity to HIV-1 infection through alternative polyadenylation

Abstract Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response1. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV-1 cores to regulate trafficking2, nuclear import3-5, uncoating6, and integration ...
Judd Hultquist, Daphne Cornish, Kathryn Jackson-Jones, Ted Ling-Hu, Lacy Simons, William Cisneros, Edmund Kuffour, Francesca Agnes, Yujin Lee, Paul Bieniasz, Ramon Lorenzo-Redondo   +10 more
openaire   +2 more sources

Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM

Cell Reports
Summary: One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors.
Matthew Cook, Christian Freniere, Chunxiang Wu, Faith Lozano, Yong Xiong   +4 more
doaj   +1 more source

Cleavage and Polyadenylation Specific Factor 6 (CPSF6): A possible protein mediator for CARM1 and pre-MRNA splicing

, 2008
1 p. (abstract only). YOU CANNOT OPEN THE COMPLETE PAPER. It is not available to the public, in accordance with the author's wishes.Coactivated associated methyltransferase 1 (CARM1), an enzyme that regulates cellular processes via arginine methylation,
Ang, SiangYun
core  

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia

Nature Communications
Acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) fusions, which exhibits clinical features resembling acute promyelocytic leukemia (APL), has been identified as a new subtype with poor clinical outcomes.
Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu   +11 more
doaj   +1 more source