Results 121 to 130 of about 2,100 (181)

The Role of Cleavage and Polyadenylation Spcific Factor 6 (CPSF6) in Hematopoiesis

Cleavage and polyadenylation specific factor 6 (Cpsf6) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis ...
Ye, Fengxi
core  

CPSF6 deficiency increases the use of proximal PASs in many immune-related genes.

(a) The genes with APA involved in virus recognition and signal transduction were shown. The black arrows indicate signal transduction. The x axis of the line graphs denotes infection time points and the y axis denotes normalized 3’ UTR length. Asterisk (
Rong Chen (29176), Jingrong Huang (12354340), Yonggui Fu (109340), Xin Ou (1872004), Anlong Xu (24151), Yi Lin (49406), Tao Ling (704718), Xiaohui Rong (3354842), Fengyi Zhou (9034415), Chuanjian Lu (534232), Shaochun Yuan (7397426), Yong Ge (816832), Youxiang Cheng (18071604)   +12 more
core   +1 more source

Primate-specific SSX1 is required for CPSF6-dependent spermatocyte transcription and human fertility

Abstract Genetic variation is a major cause of male infertility, and defining the underlying mechanisms is essential for developing effective interventions. SSX1 is a primate specific gene whose deficiency has been linked to sperm malformations in humans and cynomolgus monkeys, yet ...
Rong Hua, Qingsong Xie, Xuan Sha, Meizhou Liu, Guotong Li, Xun Xia, Yuqian Li, Yudie Guo, Mengting Xie, Chuan Xu, Hao Geng, Xiaojin He, Y Cao, Huan Wu   +13 more
openaire   +1 more source

3'UTR Mapping Reveals Alternative Polyadenylation in Right Ventricular Failure. [PDF]

Circ Res
Neupane R, Natarajan K, Suarez EE, Pownall HJ, Huang KL, Wagner EJ, Verma AK, Majji R, Yalamanchili HK, Guha A, Thandavarayan RA.   +10 more
europepmc   +1 more source

Alternative polyadenylation links RNA processing to iron metabolism in human erythropoiesis. [PDF]

Nucleic Acids Res
Yu S, Zeng X, Chen J, Lou Z, Jiang T, Ou Y, Du P, Rao J, Dai X, Gong M, Xu J, Yi P, Wang F, Wang X, Zhu Y.   +14 more
europepmc   +1 more source

Cleavage and polyadenylation specific factor 6 (CPSF6); cyclophilin A (CYPA; PPIA) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles. [PDF]

EMBO J
Müller TG, Klaus S, Zila V, Lucic B, Penzo C, Nopper SL, Golani G, Anders-Össwein M, Sonntag-Buck V, Heuser AM, Schwarz US, Laketa V, Lusic M, Müller B, Kräusslich HG.   +14 more
europepmc   +1 more source

CRISPR/Cas9 screening with destabilized bicistronic fluorescent protein reporter revealed PABPN1 as a hub of regulators for alternative polyadenylation. [PDF]

Nucleic Acids Res
Hu Z, Liu Y, Han Y, Li M, Deng K, Lu X, Huang Y, Liang C, Wang Y, Fu Y, Xu A.   +10 more
europepmc   +1 more source

Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition. [PDF]

Nat Struct Mol Biol
Fu L, Cheng S, Riedel D, Kopecny L, Schuh M, Görlich D.   +5 more
europepmc   +1 more source

HVIface: sequence-based deep learning for decoding human-virus protein-protein interfaces. [PDF]

Front Bioinform
Gupta KK, Vijayvargiya M, Paul G, Philip NS, Chauhan R.   +4 more
europepmc   +1 more source