Results 121 to 130 of about 1,827 (136)

HIV-1-induced translocation of CPSF6 to biomolecular condensates

Trends in Microbiology
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68) is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates mRNA alternative polyadenylation (APA) and determines 3' untranslated region (UTR) length, an important gene expression control mechanism.
Felipe Diaz-Griffero
exaly   +3 more sources

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6 [PDF]

Retrovirology, 2013
Abstract Background Expression of the cellular karyopherin TNPO3/transportin-SR2/Tnp3 is necessary for HIV-1 infection. Depletion of TNPO3 expression in mammalian cells inhibits HIV-1 infection after reverse transcription but prior to integration.
Jose Carlos Valle-Casuso, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero   +2 more
exaly   +3 more sources

Expression of zebrafish cpsf6 in embryogenesis and role of protein domains on subcellular localization

Gene Expression Patterns, 2020
CPSF6 is a component of the CFIm complex, involved in mRNA 3'end processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood.
Borini Etichetti, Carla Maria, Tenaglia, Albano Heraldo, Arroyo, María Nicol, Girardini Brovelli, Javier Enrique   +3 more
openaire   +3 more sources

E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages

Cell Reports
Transcriptome-wide alternative polyadenylation (APA) is involved in both innate and adaptive immune responses of immune cells. Downregulation of the CPSF6 protein, one of the 3' end-processing factors, mediates APA in macrophages with responses to virus infection and plays an important role in its anti-virus effect.
Zhijie Hu, Anlong Xu
exaly   +3 more sources

Detection of CPSF6 in Biomolecular Condensates as a Reporter of HIV-1 Nuclear Import

The initial stages of HIV-1 infection involve the transport of the viral core into the nuclear compartment. The presence of the HIV-1 core in the nucleus triggers the translocation of CPSF6/CPSF5 from paraspeckles into nuclear speckles, forming puncta-like structures.
Charlotte, Luchsinger, Felipe, Diaz-Griffero   +1 more
openaire   +2 more sources

[The nuclear translocation of circRNA CPSF6 promotes apoptosis of trophoblast cells induced by homocysteine].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2022
Objective To investigate the role of circular RNA cleavage and polyadenylation specificity factor 6 (circRNA CPSF6) in the apoptosis of trophoblast cells induced by homocysteine (Hcy) and its mechanism. Methods HTR-8/SVneo human chorionic trophoblast cells were cultured in vitro and divided into control group (0 mmol/L Hcy treatment) and 1 mmol/L Hcy ...
Lina, Gao, Qirui, Wu, He, Yin, Linying, Liu, Yuzhu, Wu, Yuyue, Zhang, Yanhua, Wang, Kai, Wu, Huiping, Zhang   +8 more
openaire   +1 more source

m6A-mediated regulation of CPSF6 by METTL3 promotes oxaliplatin resistance in colorectal cancer through enhanced glycolysis

Cellular Signalling
Oxaliplatin resistance poses a significant challenge in colorectal cancer (CRC) treatment. Recent studies have implicated CPSF6 in cancer progression and drug resistance, although its role in chemotherapy resistance and regulatory mechanisms is unclear.
Chengxing, Wang, Weijun, Liang, Jietao, Zhong, Jiachen, Liu, Chaorong, Zhou, Changyi, Ma, Yuehua, Liao, Yuan, Gao, Jinglin, Zhao, Yaoming, He   +9 more
exaly   +3 more sources

The Oncogenic Role and Potential Treatment of a Novel CPSF6-Rarg Fusion in Myeloid Transformation

Blood, 2022
Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Suning Chen, Yang Xu, Depei Wu   +6 more
openaire   +1 more source

Deregulated expression and subcellular localization of CPSF6, a circRNA-binding protein, promote malignant development of esophageal squamous cell carcinoma

Chinese Journal of Cancer Research: Official Journal of China Anti-Cancer Association, Beijing Institute for Cancer Research, 2022
Zitong Zhao, Dan Li, Yongmei Song
exaly  

CPSF6-mediated XBP1 3’UTR shortening attenuates cisplatin-induced ER stress and elevates chemo-resistance in lung adenocarcinoma

Drug Resistance Updates, 2023
Jing Chen
exaly