Results 81 to 90 of about 2,267 (171)
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao +6 more
wiley +1 more source
Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.ABSTRACT Maternally inherited transcripts are crucial for the developmental competence of salmon embryos. Due to the wide variety of broodstock conditioning approaches used in commercial aquaculture, there is a need to understand how dynamic commercial environments impact the egg transcriptome and subsequent quality.
Xin Zhan +4 more
wiley +1 more source
Depletion of CPSF6 induces a global shift towards shorter 3′ UTRs.
, 2023 (A) Histogram of the center of read distribution along the 3′ UTR, normalized to the length of the isoform’s 3′ UTR (NCOM), in control (blue) and CPSF6-depleted (red) cells.
Stella Koutsouli (16462758) +10 more
core +1 more source
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract INTRODUCTION Aging is the main risk factor for Alzheimer's disease (AD), acting through still poorly understood mechanisms. AD is associated with the development of a tau pathology, a hallmark lesion propagating in the brain along neuroanatomically connected pathways.
Andreea‐Claudia Kosa +15 more
wiley +1 more source
In vitro-derived CPSF6-resistant virus may alter CPSF6 binding.
, 2014 (A) HeLa cells stably transduced with the control vector LPCX or one overexpressing CPSF6-358 were infected with VSV-G-pseudotyped GFP reporter viruses. Results are one representative experiment of at least three independent experiments. (B) WT, RKLM and
Matthew S. Henning (507871) +4 more
core +1 more source
, 2023 All 1,924 differentially expressed isoforms between wild-type and CPSF6-depleted cells at 37°C as detected by the nbinomTest function of DESeq are deposited in the table.
Stella Koutsouli (16462758) +10 more
core +1 more source
Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis
Aging Cell, Volume 24, Issue 10, October 2025.In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang +14 more
wiley +1 more source
Mutations that reduce CA binding to CPSF6 rescue T54A.
, 2014 (A) HeLa cells stably transduced with the control LPCX vector or one overexpressing CPSF6-358 were infected with VSV-G-pseudotyped GFP reporter viruses.
Matthew S. Henning (507871) +4 more
core +1 more source
HIV-1 CA, CPSF6 and SC35 staining during infection.
, 2021 HeLa cells were synchronously infected with equal RT units of WT, A14C/E45C, E180C or M68C/E212C VLP and fixed at 16hpi. Cells were incubated with primary antibodies against HIV-1 CA and CPSF6 (A) or CPSF6 and SC35 (B) followed by specific secondary ...
Kate N. Bishop (11457941) +5 more
core +1 more source