Results 31 to 40 of about 1,827 (136)

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

Scientific Reports, 2023
The early events of HIV-1 infection involve the transport of the viral core into the nucleus. This event triggers the translocation of CPSF6 from paraspeckles into nuclear speckles forming puncta-like structures.
Charlotte Luchsinger, KyeongEun Lee, Gonzalo A. Mardones, Vineet N. KewalRamani, Felipe Diaz-Griffero   +4 more
doaj   +1 more source

The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma

Aging, 2022
Cleavage and polyadenylation specific factor 6 (CPSF6), a member of serine/arginine-rich protein family, is implicated in HIV-1-infection and replication. Overexpression of CPSF6 predicts poor prognostic outcomes of breast cancer. However, the expression and possible function of CPSF6 in lung adenocarcinoma (LUAD) still needs to be explored.
Zu, Yukun, Wang, Dao, Ping, Wei, Sun, Wei   +3 more
openaire   +2 more sources

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia

Nature Communications
Acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) fusions, which exhibits clinical features resembling acute promyelocytic leukemia (APL), has been identified as a new subtype with poor clinical outcomes.
Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu   +11 more
doaj   +3 more sources

Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock

PLOS Biology, 2023
A defining property of circadian clocks is temperature compensation, characterized by the resilience of their near 24-hour free-running periods against changes in environmental temperature within the physiological range. While temperature compensation is evolutionary conserved across different taxa of life and has been studied within many model ...
Christoph Schmal, Bert Maier, Reut Ashwal-Fluss, Osnat Bartok, Anna-Marie Finger, Tanja Bange, Stella Koutsouli, Maria S. Robles, Sebastian Kadener, Hanspeter Herzel, Achim Kramer   +10 more
openaire   +3 more sources

Ribonucleic acid-binding protein CPSF6 promotes glycolysis and suppresses apoptosis in hepatocellular carcinoma cells by inhibiting the BTG2 expression

BioMedical Engineering OnLine, 2021
Hepatocellular carcinoma (HCC) is currently the sixth most common malignancy and the second major cause of tumor-related deaths in the world. This study aimed to investigate the role of cleavage and polyadenylation factor-6 (CPSF6) and B-cell ...
Yang Liu, Hongbo Zou, Qichao Xie, Lan Zou, Rui Kong, Bijing Mao   +5 more
doaj   +1 more source

A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

eLife, 2023
Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the discovery that the mTORC1 signaling pathway balances the expression of two Trim9/TRIM9 isoforms through APA regulation in human and mouse.
R Samuel Herron, Alexander K Kunisky, Jessica R Madden, Vivian I Anyaeche, May Z Maung, Hun-Way Hwang   +5 more
doaj   +1 more source

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Events that occur between entry of the HIV-1 capsid into the cytoplasm of the target cell and the delivery of the viral genetic material into the nucleus constitute some of the less well understood processes in the viral life cycle.
Akash, Bhattacharya, Steven L, Alam, Thomas, Fricke, Kaneil, Zadrozny, Jaroslaw, Sedzicki, Alexander B, Taylor, Borries, Demeler, Owen, Pornillos, Barbie K, Ganser-Pornillos, Felipe, Diaz-Griffero, Dmitri N, Ivanov, Mark, Yeager   +11 more
openaire   +2 more sources

Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration [PDF]

JoLS, Journal of Life Sciences, 2019
HIV-1 integration favors active chromatin, which is primarily mediated through interactions between the viral capsid and integrase proteins with host factors cleavage and polyadenylation specificity factor 6 (CPSF6) and lens epithelium-derived growth factor/p75, respectively.
Vasudevan, Achuthan, Jill M, Perreira, Jenny J, Ahn, Abraham L, Brass, Alan N, Engelman   +4 more
openaire   +2 more sources

RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer

World Journal of Gastrointestinal Oncology, 2023
Pancreatic cancer (PanCa) presents a catastrophic disease with poor overall survival at advanced stages, with immediate requirement of new and effective treatment options. Besides genetic mutations, epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target. Mechanisms beneath the deoxyribonucleic
Wang, Xue-Jun, Liu, Yong, Ke, Bin, Zhang, Li, Liang, Han   +4 more
openaire   +2 more sources

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration [PDF]

Nucleic Acids Research
Sooin Jang, Parmit K Singh, Christian Freniere   +2 more
exaly   +2 more sources