Results 31 to 40 of about 2,100 (181)
Journal of Molecular Biology, 2023 Viruses are obligate parasites that rely on their host's cellular machinery for replication. To facilitate their replication cycle, many viruses have been shown to remodel the cellular architecture by inducing the formation of membraneless organelles (MLOs).
Ay, Selen, Di Nunzio, Francesca
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The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma
Aging, 2022 Cleavage and polyadenylation specific factor 6 (CPSF6), a member of serine/arginine-rich protein family, is implicated in HIV-1-infection and replication. Overexpression of CPSF6 predicts poor prognostic outcomes of breast cancer. However, the expression and possible function of CPSF6 in lung adenocarcinoma (LUAD) still needs to be explored.
Zu, Yukun +3 more
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PP 1.17 – 00103 The Ubiquitin Ligase ITCH and CPSF6 Control HIV Transcription
Journal of Virus Eradication, 2022 V. Planelles +4 more
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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Events that occur between entry of the HIV-1 capsid into the cytoplasm of the target cell and the delivery of the viral genetic material into the nucleus constitute some of the less well understood processes in the viral life cycle.
Akash, Bhattacharya +11 more
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BioMedical Engineering OnLine, 2021 Hepatocellular carcinoma (HCC) is currently the sixth most common malignancy and the second major cause of tumor-related deaths in the world. This study aimed to investigate the role of cleavage and polyadenylation factor-6 (CPSF6) and B-cell ...
Yang Liu +5 more
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eLife, 2023 Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the discovery that the mTORC1 signaling pathway balances the expression of two Trim9/TRIM9 isoforms through APA regulation in human and mouse.
R Samuel Herron +5 more
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PLOS Biology, 2023 A defining property of circadian clocks is temperature compensation, characterized by the resilience of their near 24-hour free-running periods against changes in environmental temperature within the physiological range. While temperature compensation is evolutionary conserved across different taxa of life and has been studied within many model ...
Christoph Schmal +10 more
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Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration [PDF]
JoLS, Journal of Life Sciences, 2019 HIV-1 integration favors active chromatin, which is primarily mediated through interactions between the viral capsid and integrase proteins with host factors cleavage and polyadenylation specificity factor 6 (CPSF6) and lens epithelium-derived growth factor/p75, respectively.
Vasudevan, Achuthan +4 more
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Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection
Nature Communications, 2022 Host proteins CPSF6, NUP153, and SEC24C are vital for HIV-1 infection. They bind to the viral capsid protein and contribute to shuttling of virions through the cytoplasm (SEC24C), import into the nucleus (NUP153 and CPSF6) and subsequent trafficking to ...
Guochao Wei +18 more
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Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
mBio, 2021 CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin.
Yue Zheng +7 more
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