Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration [PDF]
Therapeutic Advances in Hematology, 2021 Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han +7 more
doaj +3 more sources
eLife, 2019 Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
David Alejandro Bejarano +9 more
doaj +3 more sources
SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing [PDF]
iScienceSummary: The overall survival of patients with metastatic bladder cancer (BCa) remains poor. There is a lack of effective therapies and reliable biomarkers for metastatic BCa. BCa cells initially disseminate via the pelvic lymph nodes (LN).
Jijie Hu +11 more
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HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells [PDF]
VirusesThe HIV-1 capsid (CA) protein forms the outer shell of the viral core that is released into the cytoplasm upon infection. CA binds various cellular proteins, including CPSF6, that direct HIV-1 integration into speckle-associated domains in host chromatin.
Anabel Guedán +3 more
doaj +2 more sources
Identification of pathological pathways centered on circRNA dysregulation associated with early pathogenic progression of Alzheimer’s disease [PDF]
Alzheimers DementAbstract Background Circular RNAs (circRNAs) play multifaceted roles to precisely control expression of broad gene networks. These highly stable molecules are often accumulated in the mammalian brain and thought to serve as “memory molecules” that govern the long process of aging.
Wang F, Li Y, Shen H, Feng Y, Yao B.
europepmc +2 more sources
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease [PDF]
Genome MedicineBackground Circular RNAs (circRNAs) are highly stable regulators, often accumulated in mammalian brains and thought to serve as “memory molecules” that govern the long process of aging.
Feng Wang +10 more
doaj +2 more sources
Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM [PDF]
Cell ReportsSummary: One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors.
Matthew Cook +4 more
doaj +2 more sources
Cell Reports, 2015 Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an imaging approach, ViewHIV, which allows evaluation of early HIV-1 replication intermediates ...
Alan N Engelman +2 more
exaly +3 more sources
Journal of Molecular Biology, 2023 Viruses are obligate parasites that rely on their host's cellular machinery for replication. To facilitate their replication cycle, many viruses have been shown to remodel the cellular architecture by inducing the formation of membraneless organelles (MLOs).
Ay, Selen, Di Nunzio, Francesca
openaire +3 more sources
PP 1.17 – 00103 The Ubiquitin Ligase ITCH and CPSF6 Control HIV Transcription
Journal of Virus Eradication, 2022 V. Planelles +4 more
doaj +2 more sources