Results 21 to 30 of about 2,267 (171)

Block-and-Lock Approaches for HIV Cure: Mechanistic Insights, Challenges, and Emerging Role of CPSF6. [PDF]

Int J Mol Sci
The block-and-lock strategy aims to achieve a functional cure for human immunodeficiency virus type 1 (HIV-1) infection by enforcing durable, drug-independent silencing of proviral transcription. Several latency-promoting agents have been described that effectively limit viral reactivation in vitro or in animal models.
Tolomeo M, Cascio A.
europepmc   +2 more sources

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

eLife, 2019
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
David Alejandro Bejarano, Ke Peng, Vibor Laketa, Kathleen Börner, K Laurence Jost, Bojana Lucic, Bärbel Glass, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich   +9 more
doaj   +3 more sources

HIV-1 uncoating location dictates sites of integration [PDF]

Nature Communications
HIV-1 cores enter the nucleus and undergo capsid disassembly (uncoating) near their integration site. Although most viral cores are localized to nuclear speckles (NSs), the spatial relationship between the uncoating site and integration site remains ...
Ryan C. Burdick, Sean C. Patro, Ellie Bare, Rokeya Siddiqui, Krista A. Delviks-Frankenberry, Olga A. Nikolaitchik, Stephen H. Hughes, Xiaolin Wu, Wei-Shau Hu, Vinay K. Pathak   +9 more
doaj   +2 more sources

Unique Genetic and Epigenetic Alterations in Glioblastoma Long-Term Survivors: Insights From Two Clinical Cases. [PDF]

J Cell Mol Med
ABSTRACT The biological mechanisms driving the long survival in glioblastoma (GBM). Five‐year long‐term survival (LTS) and 10‐year survival very long‐term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR10‐046 (VLTS) was affected by a giant cell‐GBM, classified as the pedHGG_RTK1a subtype according to the ...
Anghileri E, Miele E, Patrizi S, Barresi S, Lazzarini E, Maddaloni L, Patanè M, Pedace L, Paterra R, Silvani A, Locatelli F, Indraccolo S, Pollo B.   +12 more
europepmc   +2 more sources

Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs [PDF]

Life Science Alliance
PARN regulates poly(A) lengths of pri-miR-29a and pri-miR-1207, which in turn target PARN mRNA. CPSF6 recruits PARN to pri-miRNAs, modulating miRNA levels and cell migration, revealing a dynamic mutual feedback between PARN and specific microRNAs.
Athanasios Kyritsis, Rafailia AA Beta, Diana Scutelnic, Vasiliki Stravokefalou, Valerio Del Vescovo, Zoi V Arsenopoulou, Konstantinos Papikinos, Margherita Grasso, Francesca Fontana, Paraskevi Moutopoulou, Alexandros Tsiporis, Martina Samiotaki, George Panayotou, Michela A Denti, Nikolaos AA Balatsos   +14 more
doaj   +2 more sources

Hiding in Plain Sight: HIV-1 Membraneless Organelles as Nuclear Hubs—Host Hijacking, Replication, Immune Evasion, and Drug-Access Implications [PDF]

Pathogens
Theories on the early steps of the HIV-1 life cycle have been radically revised over the past five years. The long-held assumption that the capsid fully disassembles in the cytoplasm has given way to a more nuanced view: Cytoplasmic disassembly does ...
Francesco Broccolo, Alessandro Sannino, Mauro Pollini, Federica Paladini, Thierry Mourer, Francesca Di Nunzio   +5 more
doaj   +2 more sources

Expression of zebrafish cpsf6 in embryogenesis and role of protein domains on subcellular localization

Gene Expression Patterns, 2020
CPSF6 is a component of the CFIm complex, involved in mRNA 3´end processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood ...
Girardini Brovelli, Javier Enrique, Tenaglia, Albano Heraldo, Arroyo, María Nicol, Borini Etichetti, Carla Maria   +3 more
core   +4 more sources

Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration [PDF]

Therapeutic Advances in Hematology, 2021
Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han, Chunxiang Jin, Gaofeng Zheng, Yi Li, Yungui Wang, Enfan Zhang, Honghu Zhu, Zhen Cai   +7 more
doaj   +3 more sources

SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing [PDF]

iScience
Summary: The overall survival of patients with metastatic bladder cancer (BCa) remains poor. There is a lack of effective therapies and reliable biomarkers for metastatic BCa. BCa cells initially disseminate via the pelvic lymph nodes (LN).
Jijie Hu, Ying Zhu, Guoli Wang, Huiqi Dai, Haoyuan Han, Wenmin Cao, Meng Ding, Wenli Diao, Qun Lu, Qing Zhang, Hongqian Guo, Wei Chen   +11 more
doaj   +2 more sources

Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.

PLoS Pathogens
Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3' untranslated regions (3' UTRs).
Yong Ge, Jingrong Huang, Rong Chen, Yonggui Fu, Tao Ling, Xin Ou, Xiaohui Rong, Youxiang Cheng, Yi Lin, Fengyi Zhou, Chuanjian Lu, Shaochun Yuan, Anlong Xu   +12 more
doaj   +3 more sources