Results 21 to 30 of about 2,100 (181)

Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs [PDF]

Life Science Alliance
PARN regulates poly(A) lengths of pri-miR-29a and pri-miR-1207, which in turn target PARN mRNA. CPSF6 recruits PARN to pri-miRNAs, modulating miRNA levels and cell migration, revealing a dynamic mutual feedback between PARN and specific microRNAs.
Athanasios Kyritsis, Rafailia AA Beta, Diana Scutelnic, Vasiliki Stravokefalou, Valerio Del Vescovo, Zoi V Arsenopoulou, Konstantinos Papikinos, Margherita Grasso, Francesca Fontana, Paraskevi Moutopoulou, Alexandros Tsiporis, Martina Samiotaki, George Panayotou, Michela A Denti, Nikolaos AA Balatsos   +14 more
doaj   +2 more sources

NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression

Cancer Management and Research, 2020
Bi-Jun Wang,1,* Da-Chao Liu,1,* Qian-Ying Guo,2,* Xiao-Wen Han,2 Xiao-Min Bi,2 Hao Wang,2 Zheng-Sheng Wu,2 Wen-Yong Wu1 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ...
Wang BJ, Liu DC, Guo QY, Han XW, Bi XM, Wang H, Wu ZS, Wu WY   +7 more
doaj   +5 more sources

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

eLife, 2019
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
David Alejandro Bejarano, Ke Peng, Vibor Laketa, Kathleen Börner, K Laurence Jost, Bojana Lucic, Bärbel Glass, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich   +9 more
doaj   +3 more sources

SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing [PDF]

iScience
Summary: The overall survival of patients with metastatic bladder cancer (BCa) remains poor. There is a lack of effective therapies and reliable biomarkers for metastatic BCa. BCa cells initially disseminate via the pelvic lymph nodes (LN).
Jijie Hu, Ying Zhu, Guoli Wang, Huiqi Dai, Haoyuan Han, Wenmin Cao, Meng Ding, Wenli Diao, Qun Lu, Qing Zhang, Hongqian Guo, Wei Chen   +11 more
doaj   +2 more sources

HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells

Viruses
The HIV-1 capsid (CA) protein forms the outer shell of the viral core that is released into the cytoplasm upon infection. CA binds various cellular proteins, including CPSF6, that direct HIV-1 integration into speckle-associated domains in host chromatin.
Anabel Guedan, Kate N Bishop
exaly   +3 more sources

The functional interplay between TNPO3, CPSF6 and HIV-1 CA [PDF]

, 2014
Lentiviruses can infect postmitotic cells, indicative of a role for the nucleocytoplasmic transport machinery. Genome-wide RNA interference screens identified transportin 3 (TNPO3) that may regulate human immunodeficiency virus type 1 (HIV-1) preintegration complex (PIC) nuclear import but plays no role during murine leukemia virus (MLV) infection ...
Oztop, Ilker
openaire   +2 more sources

Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration [PDF]

Therapeutic Advances in Hematology, 2021
Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han, Chunxiang Jin, Gaofeng Zheng, Yi Li, Yungui Wang, Enfan Zhang, Honghu Zhu, Zhen Cai   +7 more
doaj   +3 more sources

Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.

PLoS Pathogens
Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3' untranslated regions (3' UTRs).
Yong Ge, Jingrong Huang, Rong Chen, Yonggui Fu, Tao Ling, Xin Ou, Xiaohui Rong, Youxiang Cheng, Yi Lin, Fengyi Zhou, Chuanjian Lu, Shaochun Yuan, Anlong Xu   +12 more
doaj   +3 more sources

Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM [PDF]

Cell Reports
Summary: One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors.
Matthew Cook, Christian Freniere, Chunxiang Wu, Faith Lozano, Yong Xiong   +4 more
doaj   +2 more sources

Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease [PDF]

Genome Medicine
Background Circular RNAs (circRNAs) are highly stable regulators, often accumulated in mammalian brains and thought to serve as “memory molecules” that govern the long process of aging.
Feng Wang, Yangping Li, Huifeng Shen, Paula Martinez-Feduchi, Xingyu Ji, Peng Teng, Siddharth Krishnakumar, Jian Hu, Li Chen, Yue Feng, Bing Yao   +10 more
doaj   +2 more sources