Results 81 to 90 of about 214,858 (192)

Identifying optimal capsid duplication length for the stability of reporter flaviviruses

Emerging Microbes and Infections, 2020
Mosquito-transmitted flaviviruses cause widespread disease across the world. To provide better molecular tools for drug screens and pathogenesis studies, we report a new approach to produce stable NanoLuc-tagged flaviviruses, including dengue virus ...
Coleman Baker, Yang Liu, Jing Zou, Antonio Muruato, Xuping Xie, Pei-Yong Shi   +5 more
doaj   +1 more source

Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid [PDF]

Journal of Virology, 2005
ABSTRACT The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid ...
Xuekui, Yu, Sanket, Shah, Ivo, Atanasov, Pierrette, Lo, Fenyong, Liu, William J, Britt, Z Hong, Zhou   +6 more
openaire   +2 more sources

Comparison of potential energy minimization curves of hypothetical monomer chains from non-capsid and capsid dimers.

, 2020
Compared are apo 3KXS (A) and liganded 5E0I (B) non-capsid chains with the apo T = 4 1QGT capsid chains (C). All are X-ray crystal structures of comparable resolution. There is no apo T = 3 capsid X-ray crystal structure available for comparison. The non-
Weimin Wu (505435), Norman R. Watts (1964959), Rick Huang (8735664), Naiqian Cheng (8735661), Alasdair C. Steven (2468278), Paul T. Wingfield (189022)   +5 more
core   +1 more source

Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization

Journal of Virology
Human astroviruses (HAstVs) are a leading cause of viral childhood diarrhea that infects nearly every individual during their lifetime. Although human astroviruses are highly prevalent, no approved vaccine currently exists.
Sarah Lanning, Nayeli Aguilar-Hernández, Vitor Hugo B. Serrão, Tomás López, Sara M. O'Rourke, Adam Lentz, Lena Ricemeyer, Rafaela Espinosa, Susana López, Carlos F. Arias, Rebecca M. DuBois   +10 more
doaj   +1 more source

Molecular Evolution of the RNA-Dependent RNA Polymerase and Capsid Genes of Human Norovirus Genotype GII.2 in Japan during 2004–2015

Frontiers in Microbiology, 2017
The RNA-dependent RNA polymerase (RdRp) and capsid (VP1) genes of 51 GII.2 human norovirus (HuNoV) strains collected during the period of 2004–2015 in Japan were analyzed. Full-length analyses of the genes were performed using next-generation sequencing.
Kazuhiko Katayama, Hirokazu Kimura, Hirokazu Kimura, Fuminori Mizukoshi, Koo Nagasawa, Yen H. Doan, Kei Haga, Shima Yoshizumi, Yo Ueki, Michiyo Shinohara, Mariko Ishikawa, Naomi Sakon, Naoki Shigemoto, Reiko Okamoto-Nakagawa, Akie Ochi, Koichi Murakami, Akihide Ryo, Yoshiyuki Suzuki   +17 more
doaj   +1 more source

Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]

, 2008
Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Gutiérrez-Rivas, M, Baranowski, Eric, Sáiz, M, M. Gutierrez-Rivas, Sobrino, Francisco, F. Sobrino, M. Saiz, Sobrino Castelló, Francisco, Gutiérrez-Rivas, Monica, Pulido, Miguel R, M. R. Pulido, Sobrino, F, Pulido, Mr, Sáiz, Margarita, E. Baranowski, Rodríguez Pulido, Miguel Ramón   +15 more
core   +2 more sources

Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV)—a salmonid birnavirus

Journal of Virology
Birnaviruses infect a broad range of vertebrate hosts, including fish and birds, and cause substantial economic losses in the fishery and livestock industries.
Anna Munke, Amr Ahmed Abdelrahim Gamil, Aase B. Mikalsen, Han Wang, Øystein Evensen, Kenta Okamoto   +5 more
doaj   +1 more source

Comparison in structural fold space of capsid proteins and non-capsid ones.

, 2013
Capsid proteins form large, highly symmetric protein shells (left), while generic proteins form other types of complexes (right), exemplified here by an RNA polymerase elongation complex.
Shanshan Cheng (280254), Charles L. Brooks III (252269)   +1 more
core   +1 more source

Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

eLife
Lenacapavir (LEN) is the first human immunodeficiency virus type 1 (HIV-1) capsid inhibitor approved for clinical use in humans. It inhibits multiple steps of the viral life cycle; however, the molecular details of the effect of LEN on capsid structure ...
Arpa Hudait, Ryan C Burdick, Ellie K Bare, Vinay K Pathak, Gregory A Voth   +4 more
doaj   +1 more source

Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein [PDF]

, 1996
Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease.
Milon, Alain, Le Gall, Ghislaine, Petit, Frédérique, Bertagnoli, Stéphane, Vautherot, Jean-François, Boilletot, E., Laurent, S., Boucraut-Baralon, Corine, Le Gall, G., Gelfi, Jacqueline, Laurent, Sylvie, Petit, F., Boilletot, Eric, Rasschaert, Denis   +13 more
core