Cytoplasmic Dynein Promotes HIV-1 Uncoating [PDF]
Viruses, 2014 Retroviral capsid (CA) cores undergo uncoating during their retrograde transport (toward the nucleus), and/or after reaching the nuclear membrane. However, whether HIV-1 CA core uncoating is dependent upon its transport is not understood.
Lionel Berthoux, Berthoux Lionel
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Clathrin-Mediated Endocytosis in Plants: Historical to Modern Advances. [PDF]
TrafficUltrastructural studies by Bonnett and Newcomb in 1966 revealed the existence of coated vesicles budding from the plant cell plasma membrane. This review introduces this discovery and early questions regarding the biological significance of CME in plants highlighting advances in our understanding of the plant CME molecular machinery along with current ...
Mattson T, Bednarek S, Johnson A.
europepmc +2 more sources
HIV-1 uncoating location dictates sites of integration [PDF]
Nature CommunicationsHIV-1 cores enter the nucleus and undergo capsid disassembly (uncoating) near their integration site. Although most viral cores are localized to nuclear speckles (NSs), the spatial relationship between the uncoating site and integration site remains ...
Ryan C. Burdick +9 more
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Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry [PDF]
Microbiology SpectrumEnterovirus A71 (EV-A71) causes hand-foot-mouth disease, which may progress to severe neurological and systemic complications in young children and infants.
Wenjing Zhang +15 more
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SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating [PDF]
Journal of VirologyClassical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this
Lin-Ke Zou +10 more
doaj +2 more sources
A Spatio-Temporal Analysis of Matrix Protein and Nucleocapsid Trafficking during Vesicular Stomatitis Virus Uncoating [PDF]
PLoS Pathogens, 2010 To study VSV entry and the fate of incoming matrix (M) protein during virus uncoating we used recombinant viruses encoding M proteins with a C-terminal tetracysteine tag that could be fluorescently labeled using biarsenical (Lumio) compounds.
Chad Mire +2 more
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Viruses, 2020 An assembly of capsid proteins (CA) form the mature viral core enclosing the HIV-1 ribonucleoprotein complex. Discrepant findings have been reported regarding the cellular sites and the extent of core disassembly (uncoating) in infected cells.
Gregory B Melikyan +2 more
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A Prediction Model for Uncoating Receptor Usage in Human Enteroviruses Based on Amino Acid Sequences and a Naive Bayes Algorithm [PDF]
VirusesThis study constructed a bioinformatics prediction algorithm for human enterovirus uncoating receptors based on amino acid sequences and physicochemical properties.
Yongtao Jia +3 more
doaj +2 more sources
Journal of VirologyPorcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release.
Zili Li, Zhijian Sun
exaly +3 more sources
IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating
Viruses, 2018 The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood.
Leo James, Donna Mallery, Robert Dick
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