Results 1 to 10 of about 15,312 (202)
Revisiting HIV-1 uncoating [PDF]
Retrovirology, 2010 HIV uncoating is defined as the loss of viral capsid that occurs within the cytoplasm of infected cells before entry of the viral genome into the nucleus.
Arhel Nathalie
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Cytoplasmic Dynein Promotes HIV-1 Uncoating
Viruses, 2014 Retroviral capsid (CA) cores undergo uncoating during their retrograde transport (toward the nucleus), and/or after reaching the nuclear membrane. However, whether HIV-1 CA core uncoating is dependent upon its transport is not understood.
Lionel Berthoux, Berthoux Lionel
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A Spatio-Temporal Analysis of Matrix Protein and Nucleocapsid Trafficking during Vesicular Stomatitis Virus Uncoating [PDF]
PLoS Pathogens, 2010 To study VSV entry and the fate of incoming matrix (M) protein during virus uncoating we used recombinant viruses encoding M proteins with a C-terminal tetracysteine tag that could be fluorescently labeled using biarsenical (Lumio) compounds.
Chad E Mire +2 more
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Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry [PDF]
Microbiology SpectrumEnterovirus A71 (EV-A71) causes hand-foot-mouth disease, which may progress to severe neurological and systemic complications in young children and infants.
Wenjing Zhang +15 more
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HIV-1 uncoating location dictates sites of integration [PDF]
Nature CommunicationsHIV-1 cores enter the nucleus and undergo capsid disassembly (uncoating) near their integration site. Although most viral cores are localized to nuclear speckles (NSs), the spatial relationship between the uncoating site and integration site remains ...
Ryan C. Burdick +9 more
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SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating [PDF]
Journal of VirologyClassical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this
Lin-Ke Zou +10 more
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Viruses, 2020 An assembly of capsid proteins (CA) form the mature viral core enclosing the HIV-1 ribonucleoprotein complex. Discrepant findings have been reported regarding the cellular sites and the extent of core disassembly (uncoating) in infected cells.
Ashwanth C Francis, Gregory B Melikyan
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A Prediction Model for Uncoating Receptor Usage in Human Enteroviruses Based on Amino Acid Sequences and a Naive Bayes Algorithm [PDF]
VirusesThis study constructed a bioinformatics prediction algorithm for human enterovirus uncoating receptors based on amino acid sequences and physicochemical properties.
Yongtao Jia +3 more
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Extracellular uncoating of bacteriophage MS2. [PDF]
J Mol BiolIn the early stages of infection of its host, Escherichia coli, bacteriophage MS2 sheds its icosahedral protein capsid, after which the single-stranded genomic RNA (gRNA) and maturation protein enter the cell as a complex. Although the steps preceding uncoating, which include the binding of the Mat protein to the extracellular filament F-pilus, have ...
Paine AW, Garmann RF, Manoharan VN.
europepmc +3 more sources
Journal of VirologyPorcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release.
Zhijian Sun, Weida Zhang, Zili Li
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