HIV-1 uncoating location dictates sites of integration [PDF]
Nature CommunicationsHIV-1 cores enter the nucleus and undergo capsid disassembly (uncoating) near their integration site. Although most viral cores are localized to nuclear speckles (NSs), the spatial relationship between the uncoating site and integration site remains ...
Ryan C. Burdick +9 more
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Cytoplasmic Dynein Promotes HIV-1 Uncoating
Viruses, 2014 Retroviral capsid (CA) cores undergo uncoating during their retrograde transport (toward the nucleus), and/or after reaching the nuclear membrane. However, whether HIV-1 CA core uncoating is dependent upon its transport is not understood.
Lionel Berthoux
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SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating [PDF]
Journal of VirologyClassical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this
Lin-Ke Zou +10 more
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Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry [PDF]
Microbiology SpectrumEnterovirus A71 (EV-A71) causes hand-foot-mouth disease, which may progress to severe neurological and systemic complications in young children and infants.
Wenjing Zhang +15 more
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A Prediction Model for Uncoating Receptor Usage in Human Enteroviruses Based on Amino Acid Sequences and a Naive Bayes Algorithm [PDF]
VirusesThis study constructed a bioinformatics prediction algorithm for human enterovirus uncoating receptors based on amino acid sequences and physicochemical properties.
Yongtao Jia +3 more
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Different mechanisms for human rhinovirus survival in the presence of deleterious amino acid substitutions at virion protein-protein or RNA-protein interfaces [PDF]
Journal of VirologyA combination of structure-function and genetic analyses of viruses is unveiling a wide repertoire of adaptive mechanisms for restoring biological function in the face of negative selection pressures. The fixation of second-site compensatory mutations in
Juan Carlos Gil-Redondo +4 more
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IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating
Viruses, 2018 The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood.
Leo James, Donna Mallery, Robert Dick
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Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine [PDF]
Journal of VirologyType 2 porcine reproductive and respiratory syndrome virus (PRRSV-2) poses a major threat to global swine production. While live attenuated vaccines (LAVs) remain the most effective countermeasure, the molecular mechanisms underlying PRRSV-2 attenuation ...
Yuan-Zhe Bai +13 more
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The Role of Capsid in HIV-1 Nuclear Entry
Viruses, 2021 HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán +3 more
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Fluorescent image analysis of HIV-1 and HIV-2 uncoating kinetics in the presence of old world monkey TRIM5α. [PDF]
PLoS ONE, 2015 Uncoating of Human Immunodeficiency Virus type 1 (HIV-1) and type 2 (HIV-2) conical cores is an important early step for establishment of infection.
Eri Takeda +5 more
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