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The HIV-1 capsid and reverse transcription [PDF]

Retrovirology, 2021
The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid.
Christopher Aiken, Itay Rousso
doaj   +3 more sources

The Host Cell Metabolite Inositol Hexakisphosphate Promotes Efficient Endogenous HIV-1 Reverse Transcription by Stabilizing the Viral Capsid

mBio, 2020
A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication.
Jordan Jennings, Jiong Shi, Janani Varadarajan, Parker J. Jamieson, Christopher Aiken   +4 more
doaj   +3 more sources

Initiation of HIV Reverse Transcription

Viruses, 2010
Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the
Roland Marquet, Chantal Ehresmann, Catherine Isel   +2 more
doaj   +3 more sources

Strand transfer and elongation of HIV-1 reverse transcription is facilitated by cell factors in vitro.

PLoS ONE, 2010
Recent work suggests a role for multiple host factors in facilitating HIV-1 reverse transcription. Previously, we identified a cellular activity which increases the efficiency of HIV-1 reverse transcription in vitro.
David Warrilow, Kylie Warren, David Harrich   +2 more
doaj   +3 more sources

Reverse transcription progression and genome length regulate HIV-1 core elasticity and disassembly. [PDF]

PLoS Pathogens
The structural and mechanical properties of the HIV-1 core are critical for successful infection, balancing stability for early replication and controlled disassembly for genome release.
Akshay Deshpande, Jiong Shi, Noa Rotem-Dai, Christopher Aiken, Itay Rousso   +4 more
doaj   +2 more sources

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target.

PLoS Pathogens, 2015
Reverse transcription is the central defining feature of HIV-1 replication. We previously reported that the cellular eukaryotic elongation factor 1 (eEF1) complex associates with the HIV-1 reverse transcription complex (RTC) and the association is ...
Dongsheng Li, Ting Wei, Daniel J Rawle, Fangyun Qin, Rui Wang, Dinesh C Soares, Hongping Jin, Haran Sivakumaran, Min-Hsuan Lin, Kirsten Spann, Catherine M Abbott, David Harrich   +11 more
doaj   +2 more sources

HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway [PDF]

mBio
A critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms the conical core when it rearranges around the dimeric RNA genome and associated viral proteins.
Jenna E. Eschbach, Maritza Puray-Chavez, Shawn Mohammed, Qiankun Wang, Ming Xia, Lin-Chen Huang, Liang Shan, Sebla B. Kutluay   +7 more
doaj   +2 more sources

Development and Evaluation of Real-Time Reverse Transcription Polymerase Chain Reaction Test for Quantitative and Qualitative Recognition of H5 Subtype of Avian Influenza Viruses [PDF]

Archives of Razi Institute, 2020
Avian influenza viruses (AIV) affect a wide range of birds and mammals, cause severe economic damage to the poultry industry, and pose a serious threat to humans.
S.G. Mirzaei, A. Shoushtari, A. Noori
doaj   +1 more source

Epidemiological and molecular study of Rotavirus infection among human and animal in Karbala and Basrah provinces [PDF]

Iraqi Journal of Veterinary Sciences, 2021
This study was aimed to determine the prevalence of rotaviruses in Karbala and Basrah provinces, the genetic reassortment of human and animal rotavirus strains and the novel strains.
Faten K. Aldawmy, Hazim T. Thwiny, Hassan M. Abo Almaali   +2 more
doaj   +1 more source

Retrospective quantitative detection of SARS-CoV-2 by digital PCR showing high accuracy for low viral load specimens

Journal of Infection in Developing Countries, 2022
Introduction: Accurate detection of severe acute respiratory syndrome coronavirus 2 is critical for diagnosis and disease status evaluation of Coronavirus disease 2019.
Renfei Lu, Jian Wang, Min Li, Jing He, Yaqi Wang, Jia Dong, Weihua Cai   +6 more
doaj   +1 more source