Results 21 to 30 of about 1,031,121 (258)
Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection. [PDF]
PLoS ONE, 2009 There has been accumulating evidence for the involvement of retroviral integrase (IN) in the reverse transcription of viral RNA. We previously identified a host factor, survival motor neuron-interacting protein 1 (SIP1/Gemin2) that binds to human ...
Hironori Nishitsuji +5 more
doaj +1 more source
Viruses, 2021 The human immunodeficiency virus type 1 (HIV-1) capsid and its disassembly, or capsid uncoating, has remained an active area of study over the past several decades. Our understanding of the HIV-1 capsid as solely a protective shell has since shifted with
Zachary Ingram +2 more
doaj +1 more source
Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
Retrovirology, 2018 Background SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells by its dNTP triphosphorylase activity that depletes cellular dNTPs ...
Bijan Mahboubi +4 more
doaj +1 more source
The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
Viruses, 2021 In recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression.
Nawal AlBurtamani +2 more
doaj +1 more source
Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required?
Viruses, 2011 Liu and colleagues have recently studied dynamic changes in the orientation of HIV reverse transcriptase (RT) on its nucleic acid substrate during initiation of DNA synthesis.
Matthias Götte
doaj +1 more source
Tutorial: Guidelines for Single-Cell RT-qPCR
Cells, 2021 Reverse transcription quantitative PCR (RT-qPCR) has delivered significant insights in understanding the gene expression landscape. Thanks to its precision, sensitivity, flexibility, and cost effectiveness, RT-qPCR has also found utility in advanced ...
Daniel Zucha +2 more
doaj +1 more source
Pharmaceuticals, 2021 CareVid is a multi-herbal product used in southwest Kenya as an immune booster and health tonic and has been anecdotally described as improving the condition of HIV-positive patients.
Winnie Rotich +5 more
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When is it time for reverse transcription to start and go?
Retrovirology, 2009 Upon cell infection by a retrovirus, the viral DNA polymerase, called reverse transcriptase (RT), copies the genomic RNA to generate the proviral DNA flanked by two long terminal repeats (LTR).
Darlix Jean-Luc +2 more
doaj +1 more source
Retrovirology, 2008 Reverse transcription of the genetic material of human immunodeficiency virus type 1 (HIV-1) is a critical step in the replication cycle of this virus. This process, catalyzed by reverse transcriptase (RT), is well characterized at the biochemical level.
Ennifar Eric +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source