Results 41 to 50 of about 1,473,689 (294)

Nonparametric Bayesian inference for perturbed and orthologous gene regulatory networks [PDF]

, 2012
Motivation: The generation of time series transcriptomic datasets collected under multiple experimental conditions has proven to be a powerful approach for disentangling complex biological processes, allowing for the reverse engineering of gene ...
Baumbach, Breeze, Bulyk, Christopher A. Penfold, Cooke, David L. Wild, Goda, Katherine J. Denby, Kilian, Kimbrough, Klemm, Liu, Lopato, Marbach, Marbach, Matys, Mitsuda, Ou, Park, Penfold, Prill, Rasmussen, Roth, Stegle, Tsutsui, Vicky Buchanan-Wollaston, Werhli, Werhli, Yamaguchi-Shinozaki, Äijö   +29 more
core   +2 more sources

The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter

Viruses, 2021
In recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression.
Nawal AlBurtamani, Alwin Paul, Ariberto Fassati   +2 more
doaj   +1 more source

A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern [PDF]

, 2003
The var multicopy gene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant antigens, which, through their ability to adhere to a variety of host receptors, are thought to be important virulence factors.
Sue A. Kyes, Zoe Christodoulou, Ahmed Raza, Paul Horrocks, Robert Pinches, J. Alexandra Rowe, Chris I. Newbold, Aguiar, Baruch, Beeson, Berendt, Bonnefoy, Brabin, Buffet, Bull, Chen, Chen, Church, Duffy, Fidock, Fowler, Freitas-Junior, Fried, Fried, Fried, Gardner, Gardner, Goda, Kyes, Kyes, Lambros, Lekana Douki, Marsh, Newbold, Pouvelle, Reeder, Ricke, Roberts, Robson, Rowe, Rowe, Rubio, Salanti, Scherf, Smith, Smith, Smith, Su, Taylor, Trager, Vazquez-Macias, Voss   +51 more
core   +1 more source

The propagation of perturbations in rewired bacterial gene networks [PDF]

, 2015
What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli.
Baumstark, R, Castelo, R, Francesconi, M, Hanzelmann, S, Isalan, M, Mancuso, FM, Schaerli, Y, Tsuru, S   +7 more
core   +1 more source

Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required?

Viruses, 2011
Liu and colleagues have recently studied dynamic changes in the orientation of HIV reverse transcriptase (RT) on its nucleic acid substrate during initiation of DNA synthesis.
Matthias Götte
doaj   +1 more source

Tutorial: Guidelines for Single-Cell RT-qPCR

Cells, 2021
Reverse transcription quantitative PCR (RT-qPCR) has delivered significant insights in understanding the gene expression landscape. Thanks to its precision, sensitivity, flexibility, and cost effectiveness, RT-qPCR has also found utility in advanced ...
Daniel Zucha, Mikael Kubista, Lukas Valihrach   +2 more
doaj   +1 more source

Reverse transcription of tRNA

Nucleic Acids Research, 1978
The 3' terminus of tRNA was enzymatically elongated by an oligo(A) tail. A fragment of DNA polymerase I (E. coli) was used in the presence of manganese to phase and synthesize a cleavable primer at the oligo(A)-tRNA template. When the threedimensional structure of oligo(A)-tRNA is being unfolded under conditions where the primer is still hybridized at ...
B, Wittig, S, Wittig
openaire   +3 more sources

HIV-1 Reverse Transcriptase Inhibition by Major Compounds in a Kenyan Multi-Herbal Composition (CareVid™): In Vitro and In Silico Contrast

Pharmaceuticals, 2021
CareVid is a multi-herbal product used in southwest Kenya as an immune booster and health tonic and has been anecdotally described as improving the condition of HIV-positive patients.
Winnie Rotich, Nicholas J. Sadgrove, Eduard Mas-Claret, Guillermo F. Padilla-González, Anastasia Guantai, Moses K. Langat   +5 more
doaj   +1 more source

When is it time for reverse transcription to start and go?

Retrovirology, 2009
Upon cell infection by a retrovirus, the viral DNA polymerase, called reverse transcriptase (RT), copies the genomic RNA to generate the proviral DNA flanked by two long terminal repeats (LTR).
Darlix Jean-Luc, Houzet Laurent, Mougel Marylène   +2 more
doaj   +1 more source

Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]

, 2013
<p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J., Engelsma, M.Y., Peeters, B.P.H., Rottier, P.J.M., van Beurden, S.J.   +4 more
core   +3 more sources