Results 41 to 50 of about 16,335 (189)
HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell
Frontiers in Microbiology, 2021 The first step of the intracellular phase of retroviral infection is the release of the viral capsid core in the cytoplasm. This structure contains the viral genetic material that will be reverse transcribed and integrated into the genome of infected ...
Elenia Toccafondi +2 more
doaj +1 more source
Real-time Fluorescence Measurement of Enterovirus Uncoating
Bio-Protocol, 2020 Viruses need to open, i.e., uncoat, in order to release their genomes for efficient replication and translation. Especially for non-enveloped viruses, such as enteroviruses, the cues leading to uncoating are less well known.
Visa Ruokolainen +2 more
doaj +1 more source
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
A Spotlight on Viruses—Application of Click Chemistry to Visualize Virus-Cell Interactions
Molecules, 2019 The replication of a virus within its host cell involves numerous interactions between viral and cellular factors, which have to be tightly controlled in space and time.
Thorsten G. Müller +2 more
doaj +1 more source
Entry and uncoating of enveloped viruses [PDF]
Biochemical Journal, 1994 Markus LANZREIN,* Andreas SCHLEGELt and Christoph KEMPF1§11 *Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway, t University of Colorado at Boulder, Department of Molecular, Cellular and Developmental Biology, Campus Box 347, Boulder, CO 80309-0347, U.S.A., t Institute of ...
Lanzrein, M, Schlegel, A, Kempf, C
openaire +3 more sources
Scientific Reports, 2018 The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral components interacting with the ...
Marica Grossegesse +6 more
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In situ analysis of human immunodeficiency virus uncoating.
, 2008 In situ analysis of human immunodeficiency virus ...
Omar. Perez (7974347)
core +3 more sources
Viruses, 2021 The human immunodeficiency virus type 1 (HIV-1) capsid and its disassembly, or capsid uncoating, has remained an active area of study over the past several decades. Our understanding of the HIV-1 capsid as solely a protective shell has since shifted with
Zachary Ingram +2 more
doaj +1 more source
Principles of virus uncoating: cues and the snooker ball [PDF]
, 2016 Viruses are spherical or complex shaped carriers of proteins, nucleic acids and sometimes lipids and sugars. They are metastable and poised for structural changes.
Yamauchi, Yohei +3 more
core +1 more source
Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner
Viruses, 2020 Death domain-associated protein 6 (Daxx) is a multifunctional, ubiquitously expressed and highly conserved chaperone protein involved in numerous cellular processes, including apoptosis, transcriptional repression, and carcinogenesis.
Sarah Maillet +7 more
doaj +1 more source