The neonatal Fc receptor (FcRn) is required for porcine reproductive and respiratory syndrome virus uncoating [PDF]
Journal of VirologyPorcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release.
Kang Yang +7 more
doaj +4 more sources
CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1 [PDF]
Frontiers in Microbiology, 2020 Porcine alveolar macrophages without the CD163 SRCR5 domain are resistant to porcine reproductive and respiratory syndrome virus (PRRSV) infection. However, whether the deletion of CD163 SRCR5 in MARC-145 cells confers resistance to PRRSV and interaction
Piao Yu +7 more
doaj +2 more sources
A quantitative model for virus uncoating predicts influenza A infectivity
Cell Reports, 2023 Summary: For virus infection of new host cells, the disassembly of the protective outer protein shell (capsid) is a critical step, but the mechanisms and host-virus interactions underlying the dynamic, active, and regulated uncoating process are largely ...
Alina Artcibasova +6 more
doaj +3 more sources
How Influenza Virus Uses Host Cell Pathways during Uncoating
Cells, 2021 Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population.
Etori Aguiar Moreira +2 more
doaj +3 more sources
A spatio-temporal analysis of matrix protein and nucleocapsid trafficking during vesicular stomatitis virus uncoating. [PDF]
PLoS Pathogens, 2010 To study VSV entry and the fate of incoming matrix (M) protein during virus uncoating we used recombinant viruses encoding M proteins with a C-terminal tetracysteine tag that could be fluorescently labeled using biarsenical (Lumio) compounds.
Chad E Mire +2 more
doaj +3 more sources
EPS8 Facilitates Uncoating of Influenza A Virus
Cell Reports, 2019 Summary: All viruses balance interactions between cellular machinery co-opted to support replication and host factors deployed to halt the infection. We use gene correlation analysis to perform an unbiased screen for host factors involved in influenza A ...
Gloria P. Larson +9 more
doaj +3 more sources
SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating [PDF]
Journal of VirologyClassical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this
Lin-Ke Zou +10 more
doaj +2 more sources
Dual function of CD81 in influenza virus uncoating and budding. [PDF]
PLoS Pathogens, 2013 As an obligatory pathogen, influenza virus co-opts host cell machinery to harbor infection and to produce progeny viruses. In order to characterize the virus-host cell interactions, several genome-wide siRNA screens and proteomic analyses have been ...
Jiang He +5 more
doaj +2 more sources
Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics [PDF]
mBioThe early events of the HIV-1 life cycle, such as reverse transcription, and capsid shedding commonly known as uncoating, are interdependent and tightly regulated, enabling HIV-1 to adapt to diverse host cells.
Mohammad Anwar Siddique +10 more
doaj +2 more sources
Principles of Virus Uncoating: Cues and the Snooker Ball [PDF]
Traffic, 2016 Yohei Yamauchi, Urs F Greber
exaly +2 more sources