Results 31 to 40 of about 13,089 (196)
Stability of Norwalk virus capsid protein interfaces evaluated by in-silico nanoindentation
Frontiers in Bioengineering and Biotechnology, 2015 Norwalk virus causes severe gastroenteritis for which there is currently no specific anti-viral therapy. A stage of the infection process is uncoating of the protein capsid to expose the viral genome and allow for viral replication.
Kevin J Boyd +3 more
doaj +1 more source
Membrane Interactions and Uncoating of Aichi Virus, a Picornavirus That Lacks a VP4 [PDF]
Journal of Virology, 2022 To initiate infection, viruses must enter a host cell and deliver their genome into the appropriate location. The picornavirus family of small nonenveloped RNA viruses includes significant human and animal pathogens and is also a model to understand the process of cell entry.
James T. Kelly +5 more
openaire +4 more sources
Frontiers in Microbiology, 2022 Porcine reproductive and respiratory syndrome virus (PRRSV) has plagued the pig industry for more than 30 years and causes great economic losses. At present different commercial vaccines are available but limited tools.
Xiaoxiao Zhang +3 more
doaj +1 more source
Bio-Protocol, 2019 The genome of influenza A virus (IAV) comprises eight pinlike genomic segments called vRNPs enclosed in viral capsid. During infection, uncoating is the key step for viral replication and represents an antiviral therapeutic target, but it is difficult to
Chong Qin, Xiaowei Zhang, Zongqiang Cui
doaj +1 more source
Uncoating Kinetics of Hepatitis A Virus Virions and Provirions [PDF]
Journal of Virology, 2000 ABSTRACT When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection.
N E, Bishop, D A, Anderson
openaire +2 more sources
Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles.
PLoS Pathogens, 2022 In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the capsid, which encases the viral ribonucleoprotein complex (vRNP).
Ashwanth C Francis +7 more
doaj +1 more source
Scientific Reports, 2018 The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral components interacting with the ...
Marica Grossegesse +6 more
doaj +1 more source
Insights into neutralization of animal viruses gained from study of influenza virus [PDF]
, 1991 It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process.
Outlaw, Mark C., Dimmock, N. J.
core +1 more source
The pH stability of foot-and-mouth disease virus
Virology Journal, 2017 ᅟ This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines.
Hong Yuan +14 more
doaj +1 more source
The Ubiquitin-Proteasome System Facilitates Membrane Fusion and Uncoating during Coronavirus Entry
Viruses, 2023 Although the involvement of the ubiquitin-proteasome system (UPS) in several coronavirus-productive infections has been reported, whether the UPS is required for infectious bronchitis virus (IBV) and porcine epidemic diarrhea virus (PEDV) infections is ...
Xiao Yuan +9 more
doaj +1 more source