Results 61 to 70 of about 16,335 (189)
Role of Auxilin and Heat Shock Protein 70kDa in Clathrin Uncoating [PDF]
, 2016 An interaction between auxilin and heat shock protein 70kDa (Hsc70) was initially discovered in 1995. There exists a large amount of data supporting the basis for their interaction in vitro and their function in clathrin uncoating in vivo.
Wu, Lily
core +1 more source
Infectivity and Uncoating of Adenovirus Cores
Intervirology, 1980 A temperature-sensitive mutant of adenovirus type 2 grown at 39 degrees (tsl-39 degrees) produces noninfectious physical particles. DNA and core structures derived from such virion particles, however, were found to be infectious at the permissive temperature.
A, Mirza, J, Weber
openaire +2 more sources
Stoichiometric Binding of Cyclophilin‐A to The HIV‐1 Capsid Modulates Its Mechanoelastic Properties
Small, EarlyView.The HIV‐1 capsid is a protein nanocapsule that must balance rigidity and flexibility to enter the cell nucleus. Atomic force microscopy simulations reveal that binding of the host protein Cyclophilin A tunes this mechanical response: partial coverage preserves deformability, while excessive binding induces brittleness and failure.
Juan S. Rey +2 more
wiley +1 more source
HIV Capsid Inhibitors Beyond PF74
Diseases, 2019 Human immunodeficiency virus (HIV) capsid plays important roles at multiple stages of viral replication. At the initial stages, controlled uncoating (disassembly) of the capsid ensures efficient reverse transcription of the single-stranded RNA genome ...
Carole McArthur +3 more
doaj +1 more source
Extracellular uncoating of bacteriophage MS2. [PDF]
J Mol BiolIn the early stages of infection of its host, Escherichia coli, bacteriophage MS2 sheds its icosahedral protein capsid, after which the single-stranded genomic RNA (gRNA) and maturation protein enter the cell as a complex. Although the steps preceding uncoating, which include the binding of the Mat protein to the extracellular filament F-pilus, have ...
Paine AW, Garmann RF, Manoharan VN.
europepmc +3 more sources
Iflaviruses in arthropods: when small is mighty
Insect Science, EarlyView.Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia +3 more
wiley +1 more source
Virus adaptation to heparan sulfate comes with capsid stability tradeoff
eLifeBecause of high mutation rates, viruses constantly adapt to new environments. When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS)
Han Kang Tee +8 more
doaj +1 more source
The FEBS Journal, EarlyView.RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas +4 more
wiley +1 more source
Degradation of SAMHD1 by Vpx Is Independent of Uncoating [PDF]
Journal of Virology, 2015 ABSTRACT Sterile alpha motif domain and HD domain-containing protein 1 (SAMHD1) restricts human immunodeficiency virus type 1 (HIV-1) replication in myeloid and resting T cells. Lentiviruses such as HIV-2 and some simian immunodeficiency viruses (SIVs) counteract the restriction by encoding Vpx or Vpr, accessory proteins that are packaged in ...
Paula, Jáuregui +4 more
openaire +2 more sources
How Viruses Use the VCP/p97 ATPase Molecular Machine
Viruses, 2021 Viruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and ...
Poulami Das, Jaquelin P. Dudley
doaj +1 more source