Results 81 to 90 of about 11,654 (172)

Unraveling the Motions behind Enterovirus 71 Uncoating [PDF]

Biophysical Journal, 2018
Enterovirus 71 can be a severe pathogen in small children and immunocompromised adults. Virus uncoating is a critical step in the infection of the host cell; however, the mechanisms that control this process remain poorly understood. We applied normal mode analysis and perturbation response scanning to several complexes of the virus capsid and present ...
Ross, Caroline Jane, Atılgan, Ali Rana, Taştan Bishop, Özlem, Atılgan, Canan   +3 more
openaire   +4 more sources

THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9

Вопросы вирусологии, 2019
The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva, A. V. Alimov, A. V. Rezaykin, A. G. Sergeev, A. V. Novoselov   +4 more
doaj   +1 more source

ApoE gene therapy: an overview and update [PDF]

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes [PDF]

, 2013
Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an obligate step in virus replication. The nuclear envelope separates the chromosomes from the cell cytoplasm during interphase, and different retroviral groups deal ...
Engelman, Alan, Matreyek, Kenneth A.
core   +2 more sources

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source

Protease-Dependent Uncoating of a Complex Retrovirus [PDF]

Journal of Virology, 2005
ABSTRACT Although retrovirus egress and budding have been partly unraveled, little is known about early stages of the replication cycle. In particular, retroviral uncoating, a process during which incoming retroviral cores are altered to allow the integration of the viral genome into host chromosomes, is poorly understood.
Lehmann-Che, J., M.L., Giron, Delelis, O., Lochelt, M., Bittoun, P., Tobaly-Tapiero, J., de Thé, H., Saïb, A.   +7 more
openaire   +3 more sources

SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating

Journal of Virology
Classical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this
Lin-Ke Zou, Ji-shan Bai, Rui-cong Sun, Han-fei Yang, Ming-yue Wan, Bing-qian Zhao, Bo-tao Sun, Jin-xia Chen, Jing Chen, Yan Cheng, Bin Zhou   +10 more
doaj   +1 more source

The trinity of the cortical actin in the initiation of HIV-1 infection [PDF]

, 2012
For an infecting viral pathogen, the actin cortex inside the host cell is the first line of intracellular components that it encounters. Viruses devise various strategies to actively engage or circumvent the actin structure.
Jia Guo, Mark Spear, Yuntao Wu
core   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Severe congenital microcephaly with AP4M1 mutation, a case report [PDF]

, 2017
Background: Autosomal recessive defects of either the B1, E1, M1 or S1 subunit of the Adaptor Protein complex-4 (AP4) are characterized by developmental delay, severe intellectual disability, spasticity, and occasionally mild to moderate microcephaly of ...
Abramowicz, Marc, David, Philippe, Desmyter, Laurence, Duerinckx, Sarah, Perazzolo, Camille, Pirson, Isabelle, Verhelst, Helene   +6 more
core   +2 more sources