Results 91 to 100 of about 15,312 (202)
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Small, Volume 22, Issue 14, 6 March 2026.A novel, non‐destructive, stable, direct technique, named correlated plasmon‐enhanced Raman spectroscopy (CP‐ERS), which is based on a newly‐developed highly oriented single crystalline gold quantum dots (HOSG‐QDs) chip, is developed to measure and quantify molecular vibrations and electronic structure of analytes.
Vashu Kamboj +7 more
wiley +1 more source
Viruses, 2015 Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses.
Adil Mohamed +2 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement +12 more
wiley +1 more source
mBio, 2018 Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding ...
Daniel J. Rawle +5 more
doaj +1 more source
Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription
, 2011 During the early stages of HIV-1 replication the conical capsid composed of p24 CA protein dissociates from the rest of the cytoplasmic viral complex by a process called uncoating.
Perez, Omar +5 more
core +1 more source
Identification of Capsid Mutations That Alter the Rate of HIV-1 Uncoating in Infected Cells
, 2014 After viral fusion with the cell membrane, the conical capsid of HIV-1 disassembles by a process called uncoating. We recently utilized the cyclosporine (CsA) washout assay, in which TRIM-CypA-mediated restriction of viral replication is used to detect ...
Hope, Thomas J. +3 more
core +1 more source
Cell Reports, 2017 Although microtubule motors mediate intracellular virus transport, the underlying interactions and control mechanisms remain poorly defined. This is particularly true for HIV-1 cores, which undergo complex, interconnected processes of cytosolic transport,
Viacheslav Malikov, Mojgan H. Naghavi
doaj +1 more source
A circular uncoating mechanism [PDF]
The Journal of Cell Biology, 2003 ![Graphic][1] High curvature on smaller vesicles speeds hydrolysis of Arf1-GTP. Antonny/MacmillanIn retrospect it seems obvious. If you need to uncoat a vesicle only after the vesicle has formed, use the spherical shape of the vesicle as a trigger for uncoating. Now, Joelle Bigay,
openaire +1 more source
Penetration and Uncoating of Rotaviruses in Cultured Cells
Intervirology, 1987 Early steps of replication (penetration and uncoating) of the OSU strain of porcine rotavirus were studied in MA-104 cells. After adsorption of trypsin-treated viruses at 4 degrees, followed by a shifting of the temperature to 37 degrees, particles were seen within coated pits, coated vesicles, and secondary lysosomes, indicating that virus entry ...
J E, Ludert +4 more
openaire +2 more sources