Results 71 to 80 of about 16,335 (189)
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
Stability of Norwalk virus capsid protein interfaces evaluated by in-silico nanoindentation
Frontiers in Bioengineering and Biotechnology, 2015 Norwalk virus causes severe gastroenteritis for which there is currently no specific anti-viral therapy. A stage of the infection process is uncoating of the protein capsid to expose the viral genome and allow for viral replication.
Kevin J Boyd +3 more
doaj +1 more source
Microtubules in Influenza Virus Entry and Egress
Viruses, 2020 Influenza viruses are respiratory pathogens that represent a significant threat to public health, despite the large-scale implementation of vaccination programs.
Caitlin Simpson, Yohei Yamauchi
doaj +1 more source
Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9
Вопросы вирусологии, 2019 The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva +4 more
doaj +1 more source
From delivery to integration: CRISPR‐mediated large insert gene editing in primary human T cells
Clinical &Translational Immunology, Volume 15, Issue 10, 2026.Abstract Large insert gene editing in ex vivo, primary human T cells represents an important approach for engineering next‐generation cellular immunotherapies. While CRISPR‐based editing is well‐established for small genetic modifications, large insert knock‐in remains a technical bottleneck.
Ben Buttle +2 more
wiley +1 more source
Uncoating the Herpes Simplex Virus Genome [PDF]
Journal of Molecular Biology, 2007 Initiation of infection by herpes simplex virus (HSV-1) involves a step in which the parental virus capsid docks at a nuclear pore and injects its DNA into the nucleus. Once "uncoated" in this way, the virus DNA can be transcribed and replicated. In an effort to clarify the mechanism of DNA injection, we examined DNA release as it occurs in purified ...
William W, Newcomb +2 more
openaire +2 more sources
Synaptic Proteostasis in Health and Disease
Journal of Neurochemistry, Volume 170, Issue 10, October 2026.The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley +1 more source
DNA confinement drives uncoating of the HIV Virus
, 2014 The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the ...
R. Bruinsma, I. Rouzina
core +1 more source
Structure, Function and Dynamics in Adenovirus Maturation
Viruses, 2014 Here we review the current knowledge on maturation of adenovirus, a non-enveloped icosahedral eukaryotic virus. The adenovirus dsDNA genome fills the capsid in complex with a large amount of histone-like viral proteins, forming the core.
Walter F. Mangel, Carmen San Martín
doaj +1 more source