Results 71 to 80 of about 11,654 (172)

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Membrane Uncoating of Intact Enveloped Viruses [PDF]

Journal of Virology, 2010
ABSTRACT Experiments in the 1960s showed that Sendai virus, a paramyxovirus, fused its membrane with the host plasma membrane. After membrane fusion, the virus spontaneously “uncoated” with diffusion of the viral membrane proteins into the host plasma membrane and a merging of the host and viral membranes.
openaire   +2 more sources

Adenovirus entry: Stability, uncoating, and nuclear import

Molecular Microbiology, 2022
AbstractAdenoviruses (AdVs) are widespread in vertebrates. They infect the respiratory and gastrointestinal tracts, the eyes, heart, liver, and kidney, and are lethal to immunosuppressed people. Mastadenoviruses infecting mammals comprise several hundred different types, and many specifically infect humans.
Greber, Urs F, Suomalainen, Maarit
openaire   +3 more sources

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry

Microbiology Spectrum
Enterovirus A71 (EV-A71) causes hand-foot-mouth disease, which may progress to severe neurological and systemic complications in young children and infants.
Wenjing Zhang, Yaru Liu, Quanjie Li, Dongrong Yi, Qian Liu, Saisai Guo, Jing Wang, Jianyuan Zhao, Ling Ma, Jiwei Ding, Rui Zhou, Yongcheng Ren, Yesem Talpbek, Xiaoyu Li, Yongxin Zhang, Shan Cen   +15 more
doaj   +1 more source

Nuclear Import of HIV-1

Viruses, 2021
The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly
Qi Shen, Chunxiang Wu, Christian Freniere, Therese N. Tripler, Yong Xiong   +4 more
doaj   +1 more source

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection [PDF]

, 2011
Copyright © 2012, American Society for Microbiology. All Rights ReservedThe influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
B. Nal, Barman, Barman, Bruce, Carlton, Chen, Chen, Chen, Cheung, Ciampor, Compans, Creutz, Cubells, Eierhoff, Enrich, F. Kien, Formstecher, Fromont-Racine, Gannagé, Gerke, Goswami, Grantham, Guan, Gujuluva, H. Ma, Harris, Hartshorn, Henkel, Hoffmann, Holsinger, Honda, Hui, Ichinohe, Iwatsuki-Horimoto, K. S. Tse, L. L. M. Poon, Lakadamyali, Lamb, Lamb, Lee, Li, Liu, M. Maniere, McCown, McCown, Monastyrskaya, N. Lagarde, Nayak, Nefkens, Noton, Palese, Pinto, Pinto, Pinto, Pleschka, Rossman, Rossman, Rossman, Scheiffele, Simpson-Holley, Smythe, Sun, Thaa, Thomas, Ueda, Vila de Muga, Wang, Wang, Welsch, Y. Zhang   +69 more
core   +2 more sources

Tobamoviruses CP Proteins Hijack Light‐Induced Protein (NbLIP1) to Promote Viral Replication by Facilitating VRO Formation

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2419-2438, April 2026.
ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen, Mingjie Wu, Xiao Guo, Hongmei Xu, Chenwei Feng, Duxuan Liu, Jing Hua, Yanhong Hua, Zhen He, Peter Moffett, Kun Zhang   +10 more
wiley   +1 more source

Stability of Norwalk virus capsid protein interfaces evaluated by in-silico nanoindentation

Frontiers in Bioengineering and Biotechnology, 2015
Norwalk virus causes severe gastroenteritis for which there is currently no specific anti-viral therapy. A stage of the infection process is uncoating of the protein capsid to expose the viral genome and allow for viral replication.
Kevin J Boyd, Prakhar eBansal, Jun eFeng, Eric R May   +3 more
doaj   +1 more source

Microtubules in Influenza Virus Entry and Egress

Viruses, 2020
Influenza viruses are respiratory pathogens that represent a significant threat to public health, despite the large-scale implementation of vaccination programs.
Caitlin Simpson, Yohei Yamauchi
doaj   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 547-561, March 2026.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source