Results 111 to 120 of about 11,654 (172)

Monitoring dynamics of human adenovirus disassembly induced by mechanical fatigue [PDF]

, 2013
The standard pathway for virus infection of eukaryotic cells requires disassembly of the viral shell to facilitate release of the viral genome into the host cell.
de Pablo, Pedro José, Flint, S. J., Menéndez-Conejero, R., Ortega-Esteban, A., Pérez-Berná, Ana J., San Martín, C.   +5 more
core   +2 more sources

Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating

Cell Reports, 2017
Although microtubule motors mediate intracellular virus transport, the underlying interactions and control mechanisms remain poorly defined. This is particularly true for HIV-1 cores, which undergo complex, interconnected processes of cytosolic transport,
Viacheslav Malikov, Mojgan H. Naghavi
doaj   +1 more source

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics. [PDF]

, 2015
Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper functioning of a nuclear episomal form of the viral genome called covalently closed circular (ccc) DNA.
Guo, Haitao, Guo, Ju-Tao
core   +1 more source

Analysis of the impact of TRIM5 polymorphism on retroviral replication [PDF]

This project aims to improve the SIV/rhesus macaques animal model for AIDS. TRIM5α is an antiviral molecule expressed in mammals including rhesus macaques.
Maplanka, Charlotte
core  

Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly [PDF]

, 2016
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA.
Dama, James F., Ganser-Pornillos, Barbie K., Grime, John M. A., Jensen, Grant J., Voth, Gregory A., Woodward, Cora L., Yeager, Mark J.   +6 more
core   +2 more sources

Infectivity and Uncoating of Adenovirus Cores

Intervirology, 1980
A temperature-sensitive mutant of adenovirus type 2 grown at 39 degrees (tsl-39 degrees) produces noninfectious physical particles. DNA and core structures derived from such virion particles, however, were found to be infectious at the permissive temperature.
A, Mirza, J, Weber
openaire   +2 more sources

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

eLife, 2014
Mutations in the inositol 5-phosphatase OCRL cause Lowe syndrome and Dent's disease. Although OCRL, a direct clathrin interactor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been primarily attributed to intracellular ...
Ramiro Nández, Daniel M Balkin, Mirko Messa, Liang Liang, Summer Paradise, Heather Czapla, Marco Y Hein, James S Duncan, Matthias Mann, Pietro De Camilli   +9 more
doaj   +1 more source

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Coats uncoated!

TNOA Journal of Ophthalmic Science and Research, 2022
Smital Mahadeorao Metange, Syed Mohideen Abdul Khadar   +1 more
openaire   +2 more sources

A Prediction Model for Uncoating Receptor Usage in Human Enteroviruses Based on Amino Acid Sequences and a Naive Bayes Algorithm

Viruses
This study constructed a bioinformatics prediction algorithm for human enterovirus uncoating receptors based on amino acid sequences and physicochemical properties.
Yongtao Jia, Zhenyu Xie, Guoying Zhu, Changzheng Dong   +3 more
doaj   +1 more source