Results 21 to 30 of about 15,312 (202)
Membrane Uncoating of Intact Enveloped Viruses [PDF]
Journal of Virology, 2010 ABSTRACT Experiments in the 1960s showed that Sendai virus, a paramyxovirus, fused its membrane with the host plasma membrane. After membrane fusion, the virus spontaneously “uncoated” with diffusion of the viral membrane proteins into the host plasma membrane and a merging of the host and viral membranes.
Anne M. Haywood
openaire +3 more sources
IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating
Viruses, 2018 The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood.
Robert A Dick +2 more
exaly +3 more sources
Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine [PDF]
Journal of VirologyType 2 porcine reproductive and respiratory syndrome virus (PRRSV-2) poses a major threat to global swine production. While live attenuated vaccines (LAVs) remain the most effective countermeasure, the molecular mechanisms underlying PRRSV-2 attenuation ...
Yuan-Zhe Bai +13 more
doaj +2 more sources
Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity [PDF]
Advanced ScienceActin‐ and microtubule‐based transport systems are essential for the trafficking of endocytic viruses and cargoes. Microtubules facilitate long‐distance transport; however, the precise role of actin dynamics and its regulators during virus entry ...
Meijun Jiang +10 more
doaj +2 more sources
Clathrin-Mediated Endocytosis in Plants: Historical to Modern Advances. [PDF]
TrafficUltrastructural studies by Bonnett and Newcomb in 1966 revealed the existence of coated vesicles budding from the plant cell plasma membrane. This review introduces this discovery and early questions regarding the biological significance of CME in plants highlighting advances in our understanding of the plant CME molecular machinery along with current ...
Mattson T, Bednarek S, Johnson A.
europepmc +2 more sources
The Role of Capsid in HIV-1 Nuclear Entry
Viruses, 2021 HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán +3 more
doaj +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Characterization of HIV-1 uncoating in human microglial cell lines
Virology Journal, 2020 Background After viral fusion with the cell membrane, the conical capsid of HIV-1 disassembles by a process called uncoating. Previously we have utilized the CsA washout assay, in which TRIM-CypA mediated restriction of viral replication is used to ...
Zachary Ingram +4 more
doaj +1 more source
eLife, 2021 High-resolution imaging techniques reveal new insights into the actions of the retrovirus HIV-1 inside host cells.
Gregory J Bedwell, Alan N Engelman
doaj +1 more source
The uncoating of EV71 in mature late endosomes requires CD-M6PR
Biology Open, 2022 Enterovirus 71 (EV71) is one of the causative agents of hand-foot-and-mouth disease, which in some circumstances could lead to severe neurological diseases.
Seii Ohka +10 more
doaj +1 more source