Results 21 to 30 of about 16,335 (189)
Complexity of Clathrin Coat Dynamics in Endocytosis. [PDF]
TrafficClathrin dynamics during endocytosis. Dynamic exchange of clathrin triskelia and other endocytic proteins may be critical for several processes taking place during the maturation of endocytic vesicles. ABSTRACT Clathrin‐mediated endocytosis is a process by which eukaryotic cells internalise a wide range of molecules such as signalling factors ...
Boinet AL, Roux A, Kaksonen M.
europepmc +2 more sources
RNA packaging and uncoating in simple single-stranded RNA viruses [PDF]
, 2012 Simple (non-enveloped) small, positive-sense single-stranded RNA viruses infect hosts from all kingdoms of life. However, their assembly and uncoating processes remain poorly understood. For turnip crinkle virus (TCV), 3D reconstructions by cryoelectron
Bakker, Saskia
core +5 more sources
The Role of Capsid in HIV-1 Nuclear Entry
Viruses, 2021 HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán +3 more
doaj +1 more source
Molecular Pathology, 2002 Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their
Smyth, M.S., Martin, Jan H.
openaire +3 more sources
Overlap Intensity: An ImageJ Macro for Analyzing the HIV-1 In Situ Uncoating Assay
Viruses, 2021 Capsid uncoating is at the crossroads of early steps in HIV-1 replication. In recent years, the development of novel assays has expanded how HIV-1 uncoating can be studied.
Zachary Ingram +4 more
doaj +1 more source
Enterovirus infections in children. [PDF]
Pediatr InvestigEnteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Chen X +11 more
europepmc +2 more sources
Characterization of HIV-1 uncoating in human microglial cell lines
Virology Journal, 2020 Background After viral fusion with the cell membrane, the conical capsid of HIV-1 disassembles by a process called uncoating. Previously we have utilized the CsA washout assay, in which TRIM-CypA mediated restriction of viral replication is used to ...
Zachary Ingram +4 more
doaj +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
eLife, 2021 High-resolution imaging techniques reveal new insights into the actions of the retrovirus HIV-1 inside host cells.
Gregory J Bedwell, Alan N Engelman
doaj +1 more source
Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses [PDF]
Eur J ImmunolIn this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Marchand S, Taouli S, McIlroy D.
europepmc +2 more sources