Results 71 to 80 of about 214,858 (192)
Life, 2021 The picornavirus foot-and-mouth disease virus (FMDV) is the causative agent of the economically important disease of livestock, foot-and-mouth disease (FMD). VP4 is a highly conserved capsid protein, which is important during virus entry.
Jessica Swanson +7 more
doaj +1 more source
mBio, 2018 Late in the HIV-1 replication cycle, the viral structural protein Gag is targeted to virus assembly sites at the plasma membrane of infected cells. The capsid (CA) domain of Gag plays a critical role in the formation of the hexameric Gag lattice in the ...
Mariia Novikova +10 more
doaj +1 more source
Structural Insights into the Human Astrovirus Capsid
Viruses, 2021 Astroviruses (AstVs) are non-enveloped, positive single-stranded RNA viruses that cause a wide range of inflammatory diseases in mammalian and avian hosts.
Matthew Ykema, Yizhi J. Tao
doaj +1 more source
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure [PDF]
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use.
Shah, VB +12 more
core +4 more sources
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
eLife, 2018 The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours and
Donna L Mallery +10 more
doaj +1 more source
Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach [PDF]
Molecular Pharmaceutics, 2010 Some viral vectors are potent inducers of cellular and humoral responses; therefore, viral vectors can be used to vaccinate against cancer or infectious diseases. This report will focus on adenovirus (Ad)-based vectors. Traditional viral-vector vaccination embodies the concept that the vector uses the host-cell machinery to express antigens that are ...
openaire +2 more sources
Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs [PDF]
, 2012 Hepatitis E virus (HEV), the causative agent of hepatitis E, is primarily transmitted via the fecal-oral route through contaminated water supplies, although many sporadic cases of hepatitis E are transmitted zoonotically via direct contact with infected ...
Meng, Xiang-Jin +5 more
core +1 more source
The secrets of the stability of the HIV-1 capsid
eLife, 2018 Structural and biophysical studies help to follow the disassembly of the HIV-1 capsid in vitro, and reveal the role of a small molecule called IP6 in regulating capsid stability.
Martin Obr, Hans-Georg Kräusslich
doaj +1 more source
Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation
Communications BiologyAntiretroviral therapy (ART) strategies against HIV-1 have been successful in suppressing HIV-1 replication and preventing disease progression. However, drug-resistance development, side-effects and life-long adherence of current drugs have driven the development of novel inhibitors against HIV-1. Inhibition of capsid production by targeting the highly
Florence M. Stel +6 more
openaire +2 more sources
Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines [PDF]
, 2011 Includes abstract.Includes bibliographical references (leaves 153-175).Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical ...
Pineo, Catherine
core +1 more source