Results 91 to 100 of about 214,858 (192)
Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
mBioLenacapavir (LEN) is the first-in-class viral capsid protein (CA) targeting antiretroviral for treating multi-drug-resistant HIV-1 infection. Clinical trials and cell culture experiments have identified resistance-associated mutations (RAMs) in the ...
Lorenzo Briganti +18 more
doaj +1 more source
, 2018 The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration.
Zhang, Wei +2 more
openaire +3 more sources
Biological Research, 2009 In the present work, immunogenicity of recombinant in vitro assembled hepatitis C virus core particles, HCcAg.120-VLPs, either alone or in combination with different adjuvants was evaluated in BALB/c mice. HCcAg.120-VLPs induced high titers of anti-HCcAg.
NELSON ACOSTA-RIVERO +15 more
doaj
A Potent, Long-lasting HIV Capsid Inhibitor
, 2020 Antiretroviral drugs have saved the lives of millions living with HIV/AIDS. However, problems with drug resistance limit available treatments, and inconsistent adherence to daily dosing schedules can lead to poor outcomes and new infections.
Sundquist, W.I.
core
Antibody Competition Reveals Surface Location of HPV L2 Minor Capsid Protein Residues 17–36
Viruses, 2017 The currently available nonavalent human papillomavirus (HPV) vaccine exploits the highly antigenic L1 major capsid protein to promote high-titer neutralizing antibodies, but is limited to the HPV types included in the vaccine since the responses are ...
Stephanie M. Bywaters +5 more
doaj +1 more source
Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo
Frontiers in Immunology, 2018 Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei +10 more
doaj +1 more source
The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly [PDF]
The FEBS Journal, 2009 The mature capsid of human immunodeficiency virus, HIV‐1, is formed by the assembly of copies of a capsid protein (CA). The C‐terminal domain of CA, CTD, is able to homodimerize and most of the dimerization interface is formed by a single α‐helix from each monomer.
openaire +2 more sources
Characterisation of a non-pathogenic and non-protective infectious rabbit lagovirus related to RHDV [PDF]
, 2010 The existence of non-pathogenic RHDV strains was established when a non-lethal virus named rabbit calicivirus (RCV) was characterised in 1996 in Italy.
Le Gall-Reculé, Ghislaine +20 more
core +1 more source
Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]
, 2013 Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Susan Offner +74 more
core +2 more sources
Journal of General Virology, 2005 The rotavirus capsid is made up of three concentric protein layers. The outer layer, consisting of VP7 and VP4, is lost during virus entry into the host cell. Rotavirus field isolates can be adapted to high-titre growth in tissue culture by treatment with trypsin and by supplementing the culture medium with trypsin, which cleaves VP4 into two fragments,
Benureau, Yann +4 more
openaire +4 more sources