Results 91 to 100 of about 249,247 (291)
Advanced Intelligent Discovery, EarlyView.This paper presents a computer vision (deep learning) pipeline integrating YOLOv8 and YOLOv9 for automated detection, segmentation, and analysis of rosette cellulose synthase complexes in freeze‐fracture electron microscopy images. The study explores curated dataset expansion for model improvement and highlights pipeline accuracy, speed ...
Siri Mudunuri +6 more
wiley +1 more source
Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease [PDF]
, 1990 The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by ...
Hahn, Chang S., Strauss, James H.
core
Sensing viruses by mechanical tension of DNA in responsive hydrogels
, 2013 The rapid worldwide spread of severe viral infections, often involving novel modifications of viruses, poses major challenges to our health care systems. This means that tools that can efficiently and specifically diagnose viruses are much needed.
Cherstvy, Andrey G. +2 more
core +2 more sources
Advanced Intelligent Discovery, EarlyView.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
The virus lesson: Teaching viral structure and quasi-symmetry in mixed reality. [PDF]
Protein SciAbstract Traditional approaches to teaching structural biology struggle to capture the dynamic, three‐dimensional nature of biomolecular structures. Viral capsids, which employ quasi‐symmetric arrangements, are especially difficult to conceptualize at the human scale.
Gardner A +4 more
europepmc +2 more sources
Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles [PDF]
, 2015 We present a new theory for modeling forced indentation spectral lineshapes of biological particles, which considers non-linear Hertzian deformation due to an indenter-particle physical contact and bending deformations of curved beams modeling the ...
Gijs J L Wuite +6 more
core +4 more sources
Capsid-dependent lentiviral restrictions
Journal of VirologyABSTRACT Host antiviral proteins inhibit primate lentiviruses and other retroviruses by targeting many features of the viral life cycle. The lentiviral capsid protein and the assembled viral core are known to be inhibited through multiple, directly acting antiviral proteins.
Joy Twentyman +2 more
openaire +4 more sources
Modeling capsid self-assembly: Design and analysis
, 2010 A series of simulations aimed at elucidating the self-assembly dynamics of spherical virus capsids is described. This little-understood phenomenon is a fascinating example of the complex processes that occur in the simplest of organisms.
Rapaport, D. C.
core +1 more source
Modeling Viral Capsid Assembly
Advances in chemical physics, 2013 I present a review of the theoretical and computational methodologies that have been used to model the assembly of viral capsids. I discuss the capabilities and limitations of approaches ranging from equilibrium continuum theories to molecular dynamics simulations, and I give an overview of some of the important conclusions about virus assembly that ...
openaire +3 more sources
Identification Epitope on VP4 Protein of Senecavirus A Recognized by a Monoclonal Antibody
Animal Research and One Health, EarlyView.This study aims to identify conserved antigenic epitopes on the SVA VP4 protein using monoclonal antibodies, providing valuable tools for further exploring its functions and developing detection methods. SVA VP4 protein was expressed in Escherichia coli and purified with High‐Affinity Ni‐Charged Resin FF.
Liang Meng +7 more
wiley +1 more source