Results 121 to 130 of about 249,247 (291)

Inhibition of DNA ejection from bacteriophage by Mg+2 counterions

, 2010
The problem of inhibiting viral DNA ejection from bacteriophages by multivalent counterions, specifically Mg$^{+2}$ counterions, is studied. Experimentally, it is known that MgSO$_4$ salt has a strong and non-monotonic effect on the amount of DNA ejected.
Baker T. S., C. V. Tran, Sell Lee, T. T. Nguyen   +3 more
core   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV)—a salmonid birnavirus

Journal of Virology
Birnaviruses infect a broad range of vertebrate hosts, including fish and birds, and cause substantial economic losses in the fishery and livestock industries.
Anna Munke, Amr Ahmed Abdelrahim Gamil, Aase B. Mikalsen, Han Wang, Øystein Evensen, Kenta Okamoto   +5 more
doaj   +1 more source

Aiming at the heart: the capsid protein of dengue virus as a vaccine candidate

Expert Review of Vaccines, 2019
Introduction: Dengue fever remains as a health problem worldwide. Although Dengvaxia®, was registered in several countries, the results after the immunization of people suggest an increase of risk in non-immune persons and children younger than 9 years ...
Laura Lazo, Iris Valdes, Gerardo Guillén, Lisset Hermida, Lázaro Gil   +4 more
doaj   +1 more source

Molecular dynamics study of T=3 capsid assembly

, 2018
Molecular dynamics simulation is used to model the self-assembly of polyhedral shells containing 180 trapezoidal particles that correspond to the T=3 virus capsid.
Rapaport, D. C.
core   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Residues 27T and 297A in VP2 contribute to the enhanced replication and pathogenicity of raccoon dog parvovirus

Journal of Virology
Raccoon dog parvovirus (RDPV) is a highly contagious pathogen causing severe hemorrhagic enteritis that is fatal in young raccoon dogs. Since 2016, epidemiological investigations have documented recurrent outbreaks of RDPV, exhibiting heightened ...
Liwen Xu, Wenyu Cao, Yawen Liu, Bo Hu, Chengqi Zhang, Shuangshuang Li, Jiajia Liu, Jianhai Fu, Zichuang Zhang, Yajie Sun, Guanyu Zhao, Xiaoyu Deng, Rongguang Lu, Xue Bai   +13 more
doaj   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Complex multitrophic species interactions and fitness costs: Intricate consequences of jasmonate and salicylate induced plant defences

Journal of Animal Ecology, EarlyView.
This study reveals how long‐term activation of jasmonic and salicylic acid signalling reshapes arthropod communities and plant fitness across seasons. By showing that induced defences generate contrasting outcomes and cascading trade‐offs across trophic levels, it challenges the assumption that induced resistance is uniformly beneficial in natural ...
Mônica F. Kersch‐Becker, Guilherme P. Pinheiro, Thaís S. Schweller, Martin Pareja, Victoria M. Pocius, José R. Trigo, Gustavo Q. Romero   +6 more
wiley   +1 more source