Results 111 to 120 of about 227,059 (331)
Thermodynamics of nano-spheres encapsulated in virus capsids
, 2009 We investigate the thermodynamics of complexation of functionalized charged nano-spheres with viral proteins. The physics of this problem is governed by electrostatic interaction between the proteins and the nano-sphere cores (screened by salt ions), but
Antonio Šiber +5 more
core +1 more source
The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell [PDF]
, 2012 The malaria parasite exports proteins across its plasma membrane and a surrounding parasitophorous vacuole membrane, into its host erythrocyte. Most exported proteins contain a Host Targeting motif (HT motif) that targets them for export. In the parasite
Cryar, Adam +4 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai +9 more
wiley +1 more source
The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein
mBio, 2018 Zika virus (ZIKV) infection of neural progenitor cells (NPCs) in utero is associated with neurological disorders, such as microcephaly, but a detailed molecular understanding of ZIKV-induced pathogenesis is lacking.
Krystal A. Fontaine +10 more
doaj +1 more source
Biotechnology Progress, EarlyView.This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia +7 more
wiley +1 more source
Oral Squamous Cell Carcinoma‐Risk Factors, Diagnosis, Treatment, and Prevention
Cancer Nexus, EarlyView.ABSTRACT Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of oral mucosa and accounts for approximately 90% of oral cancers. In‐depth understanding of pathogenesis, hallmarks, and etiological factors is a crucial prerequisite for advancing the diagnosis and treatment for OSCC patients. This review aims to present the
Liping Wang +4 more
wiley +1 more source
DNA Confinement drives uncoating of the HIV Virus
, 2014 We present a model for the uncoating of the HIV virus driven by forces exerted on the protein shell of HIV generated by DNA ...
Bruinsma, Robijn, Rouzina, Ioulia
core +1 more source
Capsid protein heterogeneity in turnip mosaic virus
Virology, 1976 Abstract The effect of capsid protein heterogeneity on various virus properties in purified turnip mosaic virus was investigated. Polyacrylamide-gel electrophoresis in the presence of sodium dodecyl sulfate (SDS) revealed three distinct capsid protein species, designated as fast form (MW 27,000), intermediate form (MW 29,000), slow form (MW 36,000 ...
Plant Pathology Department, University of Florida, Gainesville, Florida 32611 USA ( host institution ) +2 more
openaire +3 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott +7 more
wiley +1 more source
Electrostatic theory of viral self-assembly: a toy model
, 2007 Viruses self-assemble from identical capsid proteins and their genome consisting, for example, of a long single stranded (ss) RNA. For a big class of T = 3 viruses capsid proteins have long positive N-terminal tails.
Adolph +17 more
core +1 more source