Results 11 to 20 of about 134,019 (273)

O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide

Human Vaccines & Immunotherapeutics, 2018
Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against ...
Ingrid L. Scully, Viliam Pavliak, Yekaterina Timofeyeva, Yongdong Liu, Christine Singer, Annaliesa S. Anderson   +5 more
doaj   +2 more sources

Pneumococcal capsular polysaccharide structure predicts serotype prevalence. [PDF]

PLoS Pathogens, 2009
There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence of particular serotypes is relatively stable worldwide, but the host and bacterial factors that maintain these patterns are poorly understood. Given
Daniel M Weinberger, Krzysztof Trzciński, Ying-Jie Lu, Debby Bogaert, Aaron Brandes, James Galagan, Porter W Anderson, Richard Malley, Marc Lipsitch   +8 more
doaj   +3 more sources

In vivo role of capsular polysaccharide in Mycoplasma mycoides [PDF]

, 2019
Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals.
Schieck, Elise G., Schieck, Elise, Blanchard, Alain, Posthaus, H., Lartigue, C., Vashee, Sanjay, Vashee, S., Labroussaa, Fabien, Lartigue, Carole, Jores, Joerg, Liljander, Anne M., Liljander, Anne, Posthaus, Horst, Sacchini, Flavio, Labroussaa, F., Jores, Jörg, Lartigue C, Schieck E, Blanchard A, Posthaus H, Labroussaa F, Jores J, Liljander A, Vashee S, Sacchini F   +24 more
core   +3 more sources

A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate [PDF]

, 2016
Three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution.
Harding, Stephen E., Conrath, K., Almuntari, F., Almutairi, Fahad M., Duvivier, Pierre, Harding, S. E., Adams, G. G., Morris, Gordon, Duvivier, P., Morris, Gordon A., Abdelhameed, Ali Saber, Adams, Gary G., Abdelhameed, A. S., Conrath, Karel, GSK Vaccines, Rue de l’Institut 89, B-1330 Rixensart, Belgium, Morris, Gordon A.; id_orcid   +15 more
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Heterologous expression of the pneumococcal serotype 14 polysaccharide in Lactococcus lactis requires lactococcal epsABC regulatory genes [PDF]

, 2008
The pneumococcal serotype 14 polysaccharide was produced in Lactococcus lactis by coexpressing pneumococcal polysaccharide type 14-specific genes (cpsFGHIJKL(14)) with the lactococcal regulatory and priming glucosyltransferase-encoding genes specific for
Kleerebezem, M., Masja N. Nierop Groot, Michiel Kleerebezem, Jeroen Godefrooij, Nierop Groot, M.N., Godefrooij, J.   +5 more
core   +1 more source

Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines. [PDF]

, 2014
Bacterial polysaccharides have numerous clinical or industrial uses. Recombinant plants could offer the possibility of producing bacterial polysaccharides on a large scale and free of contaminating bacterial toxins and antigens.
G. C. Whitelam (7665758), Marie Goldrick (324989), Roberts Ian S., Garry C. Whitelam (519301), Andrew, PW, Patel, Alexandra J.F., Whitelam, Garry C, Claire M. Smith (7665743), Peter W. Andrew (153608), Roberts, Ian S, Whitelam, Garry C., Patel Alexandra J. F., Roberts, IS, K. C. Gough (7665749), Glenn, S, Gough Kevin C., Andrew, Peter W, S. C. Fry (7665746), Alexandra J F Patel, Stephen C Fry, Garry C Whitelam, Kevin C Gough, Gough, KC, Sarah Glenn (519300), Fry Stephen C., Andrew Peter W., Gough, Kevin C, Whitelam, GC, Sarah Glenn, Fry, Stephen C., Claire M. Smith (519296), Roberts, Ian S., Ian S. Roberts (159693), Whitelam Garry C., Peter W Andrew, Smith, Claire M, Patel, Alexandra J F, Patel, AJ, Fry, Stephen C, Stephen C. Fry (519297), Andrew, Peter W., Kevin C. Gough (519298), Ian S Roberts, Fry, SC, Goldrick, M, Smith Claire M., Alexandra J. F. Patel (519299), Goldrick Marie, Marie Goldrick, M. Goldrick (7665755), Goldrick, Marie, Alexandra J. F. Patel (7665752), Gough, Kevin C., Glenn, Sarah, Glenn Sarah, Smith, Claire M., Claire M Smith, Smith, CM, I. S. Roberts (6341096)   +58 more
core   +1 more source

A role for LHC1 in higher order structure and complement binding of the Cryptococcus neoformans capsule.

PLoS Pathogens, 2014
Polysaccharide capsules are important virulence factors for many microbial pathogens including the opportunistic fungus Cryptococcus neoformans. In the present study, we demonstrate an unusual role for a secreted lactonohydrolase of C.
Yoon-Dong Park, Soowan Shin, John Panepinto, Jeanie Ramos, Jin Qiu, Susana Frases, Patricia Albuquerque, Radames J B Cordero, Nannan Zhang, Uwe Himmelreich, David Beenhouwer, John E Bennett, Arturo Casadevall, Peter R Williamson   +13 more
doaj   +1 more source

Staphylococcus aureusCapsular Polysaccharides [PDF]

Clinical Microbiology Reviews, 2004
SUMMARYSerotype 5 and 8 capsular polysaccharides predominate among clinical isolates ofStaphylococcus aureus.The results of experiments in animal models of infection have revealed that staphylococcal capsules are important in the pathogenesis ofS. aureusinfections.
Katherine, O'Riordan, Jean C, Lee
openaire   +2 more sources

Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity

Communications Biology, 2023
Bacterial capsular polysaccharides are important vaccine immunogens. However, the study of polysaccharide-specific immune responses has been hindered by technical restrictions.
Dennis Hoving, Alexandre H. C. Marques, Wesley Huisman, Beckley A. Nosoh, Alicia C. de Kroon, Oscar R. J. van Hengel, Bing-Ru Wu, Rosanne A. M. Steenbergen, Pauline M. van Helden, Britta C. Urban, Nisha Dhar, Daniela M. Ferreira, Gaurav Kwatra, Cornelis H. Hokke, Simon P. Jochems   +14 more
doaj   +1 more source

ANTIGENICITY OF TYPE XII PNEUMOCOCCAL CAPSULAR POLYSACCHARIDE IN RABBITS AND MICE.

, 1957
ANTIGENICITY OF TYPE XII PNEUMOCOCCAL CAPSULAR POLYSACCHARIDE IN RABBITS AND ...
PETER. BARAM (7974104)
core   +4 more sources