Human Vaccines & Immunotherapeutics, 2018 Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against ...
Ingrid L. Scully +5 more
doaj +2 more sources
Pneumococcal capsular polysaccharide structure predicts serotype prevalence. [PDF]
PLoS Pathogens, 2009 There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence of particular serotypes is relatively stable worldwide, but the host and bacterial factors that maintain these patterns are poorly understood. Given
Daniel M Weinberger +8 more
doaj +3 more sources
Pneumococcal Capsular Polysaccharide Immunity in the Elderly [PDF]
Clinical and Vaccine Immunology, 2017 ABSTRACTImmunity to pneumococcal infections is impaired in older people, and current vaccines are poorly protective against pneumococcal disease in this population. Naturally acquired immunity to pneumococcal capsular polysaccharides develops during childhood and is robust in young adults but deteriorates with advanced age.
Hugh Adler +3 more
openaire +3 more sources
Streptococcus pneumoniae Capsular Polysaccharide
Microbiology Spectrum, 2019 ABSTRACT The polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure of the organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms.
Paton, J., Trappetti, C.
openaire +4 more sources
Antibiofilm activity of Actinobacillus pleuropneumoniae serotype 5 capsular polysaccharide. [PDF]
PLoS ONE, 2013 Cell-free extracts isolated from colony biofilms of Actinobacillus pleuropneumoniae serotype 5 were found to inhibit biofilm formation by Staphylococcus aureus, S. epidermidis and Aggregatibacter actinomycetemcomitans, but not by A.
Michael T Karwacki +6 more
doaj +2 more sources
A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate [PDF]
, 2016 Three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution.
Harding, Stephen E. +14 more
core +1 more source
Heterologous expression of the pneumococcal serotype 14 polysaccharide in Lactococcus lactis requires lactococcal epsABC regulatory genes [PDF]
, 2008 The pneumococcal serotype 14 polysaccharide was produced in Lactococcus lactis by coexpressing pneumococcal polysaccharide type 14-specific genes (cpsFGHIJKL(14)) with the lactococcal regulatory and priming glucosyltransferase-encoding genes specific for
Kleerebezem, M. +5 more
core +1 more source
Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines. [PDF]
, 2014 Bacterial polysaccharides have numerous clinical or industrial uses. Recombinant plants could offer the possibility of producing bacterial polysaccharides on a large scale and free of contaminating bacterial toxins and antigens.
G. C. Whitelam (7665758) +58 more
core +1 more source
Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes [PDF]
, 2011 Glycosaminoglycans (GAGs) are polysaccharides that are typically present in a wide diversity of animal tissue. Most common GAGs are well-characterized and pharmaceutical applications exist for many of these compounds, e.g. heparin and hyaluronan.
Kengen, S.W.M. +6 more
core +1 more source
Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates. [PDF]
, 2012 Contains fulltext : 110162.pdf (Publisher’s version ) (Closed access)The capsule polysaccharide locus (cps) is the site of the capsule biosynthesis gene cluster in encapsulated Streptococcus pneumoniae. A set of pneumococcal samples and
Bentley, S.D. +29 more
core +2 more sources