Results 101 to 110 of about 9,148 (251)

Spread of ST11-O13/KL47 hypervirulent carbapenem-resistant Klebsiella pneumoniae isolates in China

Scientific Reports
Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a serious threat to global public health. Hypervirulent CRKP (Hv-CRKP) can cause life-threatening infections, with significantly higher virulence and mortality compared to classical CRKP.
Zhiwei Liu, Huiwen Li, Tingting Li, Gongzhao Wang, Gang Li, Jing Wu, Pan Fu, Chuanqing Wang   +7 more
doaj   +1 more source

Molecular Characterization of MRSA in Seafood: Potential for Virtual Transmission Tracking

Journal of Pure and Applied Microbiology
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a persistent pathogen in the seafood industry, raising concerns for food safety. Identifying the origin and transmission of MRSA is highly critical to control its spread, thereby acts as a
Murugadas Vaiyapuri, Ancy Tony, Visnuvinayagam Sivam, Reshmi Koombankallil, Sreejith Vyyokaran Narayanan, Ezhil Nilavan Sumathi, Toms Cheriyath Joseph, Madhusudana Rao Badireddy, Mukteswar Prasad Mothadaka   +8 more
doaj   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

AN UNUSUAL TYPE OF ANTERIOR TRAUMATIC CAPSULAR CATARACT [PDF]

British Journal of Ophthalmology, 1945
openaire   +2 more sources

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source