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Bridging the gap: organotypic models to study late-onset group B streptococcus infection [PDF]

Microbiology Spectrum
Group B Streptococcus (GBS) is a major cause of neonatal sepsis worldwide. Gastrointestinal colonization by GBS is an important risk factor for late-onset disease in newborns.
Alexia N. Pearah, Nichol John-Lewis Edwards, Rico R. Carter, Leigh-Anne M. Worthington, Madison R. Huszar, Kristen Domínguez, Hannah L. Wapshott-Stehli, April K. Lindon, Sophie E. Darch, Thao T. B. Ho, Tara M. Randis   +10 more
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RodA promotes intestinal colonization by group B Streptococcus [PDF]

Infection and Immunity
Group B Streptococcus (GBS) intestinal colonization is critical for the pathogenesis of late-onset disease in infants. Using a murine model, we explore the role of rodA, which encodes a peptidoglycan polymerase RodA, belonging to the shape, elongation ...
Michelle J. Vaz, Sanjana Sankaran, Molly E. Sharp, Emily Dembinski, Adam J. Ratner   +4 more
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Group B Streptococcus Vaccines: Progress and Potential [PDF]

Annals of Clinical Microbiology, 2023
Group B Streptococcus (GBS, Streptococcus agalactiae) is a pathogen that causes sepsis and meningitis, particularly in newborns, as well as severe infections in the elderly and those at high risk.
Kristin Widyasari, Sunjoo Kim
doaj   +1 more source

NEONATAL INFECTION WITH GROUP B STREPTOCOCCUS [PDF]

Romanian Journal of Pediatrics, 2009
Group B Streptococcus (Streptococcus agalactiae). Infections colonizes the maternal urethra, vaginal tract and rectum; it is sexually transmitted but colonization is usually asymptomatic. In the mother, group B Streptococcus can cause puerperal sepsis,
Cătălin Chiriac-Babei
doaj   +1 more source

Group B streptococcus in obstetrics: unsolved problems

RUDN Journal of Medicine, 2023
For several decades, among all possible pathogens of neonatal infections, group B streptococcus has been one of the leading positions. Sepsis, meningitis, and pneumonia are among the most common clinical manifestations of neonatal infection associated ...
Victor E. Radzinsky, Olga K. Doronina, Anton S. Olenev, Olga V. Stetsyuk   +3 more
doaj   +1 more source

Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children

Frontiers in Pediatrics, 2022
ObjectiveTo investigate the associations between intrapartum antibiotic prophylaxis of group B streptococcus (GBS) in pregnant women and the risk of food allergy in Chinese childrenDesignRetrospective cohort study of 2,909 mother-child pairs ...
Hong Zhang, Kang Xu, Zhihui Liu, Yuanmei Shi, Hui Li, Xiaoping Yin   +5 more
doaj   +1 more source

Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center

Annals of Medicine, 2021
Objectives To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.Material and methods This retrospective study included adults with a positive culture ...
Pakpoom Phoompoung, Nantaporn Pirogard, Amornrut Leelaporn, Nasikarn Angkasekwinai   +3 more
doaj   +1 more source

Capsule production promotes Group B Streptococcus intestinal colonization

Microbiology Spectrum, 2023
Late-onset disease is the most common clinical presentation of Group B Streptococcus (GBS) infection during infancy, and gastrointestinal (GI) colonization is an important precursor.
Michelle J. Vaz, Sophia Dongas, Adam J. Ratner   +2 more
doaj   +1 more source

Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death

Microbiology Spectrum, 2022
Pore-forming toxins (PFTs) are commonly produced by pathogenic bacteria, and understanding them is key to the development of virulence-targeted therapies. Streptococcus agalactiae, or group B Streptococcus (GBS), produces several factors that enhance its
Ifrah Shahi, Cristina N. Llaneras, Sofya S. Perelman, Victor J. Torres, Adam J. Ratner   +4 more
doaj   +1 more source

Prevention of Perinatal Group B Streptococcus Infections

Maternal-Fetal Medicine, 2020
. Group B streptococcus (GBS) is a leading cause of neonatal infection. Maternal vaginal-rectal colonization with GBS during the intrapartum period is a prerequisite for GBS early-onset disease (EOD).
Shang-Rong Fan, Umber Tasneem, Xiao-Ping Liu, Shao-Mei Yan, Yang Pan, Dan-Dan Shi   +5 more
doaj   +1 more source