Results 21 to 30 of about 239,283 (241)

CRISPR interference in a Streptococcus agalactiae multi-locus sequence type 17 strain

Journal of Bacteriology
Group B Streptococcus (GBS), a common colonizer of the human genital and gastrointestinal tracts, is a leading cause of neonatal bacterial meningitis, which can lead to severe neurological complications.
William D. Cutts, Aidan W. Flanagan, Brice K. Gorman, Audrey Sweten, Bryan J. Estrada, Vishwas N. Subash, Benjamin T. Klemp, Kathryn N. Seely, Austin D. Sandobal, Katelin R. Stilen, Taksh Vaghela, Areebah Mehvish, Jacob F. Wood, Alexus M. Govert, Kristin E. Hobson, Gideon H. Hillebrand, Thomas A. Hooven, Brandon J. Kim   +17 more
doaj   +1 more source

Group B Streptococcus: To Culture or Not to Culture? [PDF]

Journal of Perinatology, 1999
To determine if universal Group B Streptococcus (GBS) culturing and antibiotic prophylaxis of obstetric patients decreased the incidence of neonatal early-onset GBS sepsis and mortality and maternal chorioamnionitis.A time series observational study was conducted to compare the cohort of all obstetric patients delivering at the University of Chicago ...
P F, Katz, J U, Hibbard, D, Ranganathan, W, Meadows, M, Ismail   +4 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prevalence of group B Streptococcus in pregnancy and its relation to obstetric outcome in a tertiary hospital in North Kerala

National Journal of Physiology, Pharmacy and Pharmacology
Background: GBS is an important cause of maternal and neonatal morbidity in many parts of the world, unfortunately there are not much Indian studies to know the prevalence and effect of GBS colonization in Indian pregnant women.
Ajith S., Anusree V., Beena George, Shuguftha Sherin, Pooja Shaji   +4 more
doaj   +1 more source

The antimicrobial activity of zinc against group B Streptococcus is strain-dependent across diverse sequence types, capsular serotypes, and invasive versus colonizing isolates

BMC Microbiology, 2022
Background Streptococcus agalactiae or Group B Streptococcus (GBS) is an encapsulated gram-positive bacterial pathobiont that commonly colonizes the lower gastrointestinal tract and reproductive tract of human hosts.
Jamisha D. Francis, Miriam A. Guevara, Jacky Lu, Shabir A. Madhi, Gaurav Kwatra, David M. Aronoff, Shannon D. Manning, Jennifer A. Gaddy   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Group B Streptococcus (Streptococcus agalactiae) Screening During Pregnancy

Journal of Rawalpindi Medical College, 2014
Background:An audit trial was conducted to review our practice of Universal GBS screening for our pregnant patients and its effect on fetal outcome.
Jahan Ara Saeed
doaj