Results 51 to 60 of about 977,276 (334)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Sweat collection capsule [PDF]

open access: yes, 1980
A sweat collection capsule permitting quantitative collection of sweat is described. The device consists of a frame held immobile on the skin, a closure secured to the frame and absorbent material located next to the skin in a cavity formed by the frame ...
Delaplaine, R. W., Greenleaf, J. E.
core   +1 more source

Identification of Klebsiella capsule synthesis loci from whole genome data

open access: yesbioRxiv, 2016
Background Klebsiella pneumoniae and close relatives are a growing cause of healthcare-associated infections for which increasing rates of multi-drug resistance are a major concern.
K. Wyres   +6 more
semanticscholar   +1 more source

Cell envelope defects of different capsule‐null mutants in K1 hypervirulent Klebsiella pneumoniae can affect bacterial pathogenesis

open access: yesMolecular Microbiology, 2020
Hypervirulent Klebsiella pneumoniae (hvKP) causes Klebsiella‐induced liver abscess. Capsule is important for the pathogenesis of Klebsiella in systemic infection, but its role in gut colonisation is not well understood. By generating ΔwcaJ, Δwza and Δwzy
Y. Tan   +4 more
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Optimal Preparation Protocol of Cell-Encapsulating Alginate Capsules for Long-Term Cell-Based Therapy [PDF]

open access: gold, 2023
Ryota Suzuki   +6 more
openalex   +1 more source

COMPARATIVE STUDY OF CAPSULE NEURAL NETWORK IN VARIOUS APPLICATIONS

open access: yesJournal of Artificial Intelligence and Capsule Networks, 2019
The advancement in the machine learning and the computer vision has caused several improvements and development in numerous of domains. Capsule neural networks are one such machine learning system that imitates the neural system and develops the ...
Vijayakumar T Dr
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Deep Convolutional Capsule Network for Hyperspectral Image Spectral and Spectral-Spatial Classification

open access: yesRemote Sensing, 2019
Capsule networks can be considered to be the next era of deep learning and have recently shown their advantages in supervised classification. Instead of using scalar values to represent features, the capsule networks use vectors to represent features ...
K. Zhu   +4 more
semanticscholar   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

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