Results 61 to 70 of about 33,619 (260)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Efficient-CapsNet: capsule network with self-attention routing

Scientific Reports, 2021
Deep convolutional neural networks, assisted by architectural design strategies, make extensive use of data augmentation techniques and layers with a high number of feature maps to embed object transformations.
Vittorio Mazzia, Francesco Salvetti, Marcello Chiaberge   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Mimicry Embedding Facilitates Advanced Neural Network Training for Image-Based Pathogen Detection

mSphere, 2020
The use of deep neural networks (DNNs) for analysis of complex biomedical images shows great promise but is hampered by a lack of large verified data sets for rapid network evolution.
Artur Yakimovich, Moona Huttunen, Jerzy Samolej, Barbara Clough, Nagisa Yoshida, Serge Mostowy, Eva-Maria Frickel, Jason Mercer   +7 more
doaj   +1 more source

Latent Space Coding Capsule Network for Mental Workload Classification

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023
Mental workload can be monitored in real time, which helps us improve work efficiency by maintaining an appropriate workload level. Based on previous studies, we have known that features, such as band power and brain connectivity, can be utilized to ...
Yinhu Yu, Anastasios Bezerianos, Andrzej Cichocki, Junhua Li   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Data-driven Reactive Power Optimization for Distribution Networks Using Capsule Networks

Journal of Modern Power Systems and Clean Energy, 2022
The construction of advanced metering infrastructure and the rapid evolution of artificial intelligence bring opportunities to quickly searching for the optimal dispatching strategy for reactive power optimization. This can be realized by mining existing
Wenlong Liao, Jiejing Chen, Qi Liu, Ruijin Zhu, Like Song, Zhe Yang   +5 more
doaj   +1 more source