Results 41 to 50 of about 274,203 (261)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dynamic Car-Following Model With Jerk Suppression for Highway Autonomous Driving

IEEE Access
This study proposes a dynamic safe car-following strategy that is based on dynamic adjustment of headway time with jerk suppression. Reinforcement learning models trained with this strategy result in enhanced safety and driving comfort, validated using ...
Ke Liu, Jing Ma, Edmund M.-K. Lai
doaj   +1 more source

Transmission Capacity Analysis for Vehicular Ad Hoc Networks

IEEE Access, 2018
Traditional studies focused on the transmission capacity of vehicular ad hoc network (VANET) contains two deficiencies: the lack of a realistic model mimicking the behaviors of vehicles and the failure to consider the impacts from enhanced distributed ...
Xinxin He, Weisen Shi, Tao Luo
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Critical Data Discovery for Self-Driving: A Data Distillation Approach

Applied Sciences
Deep learning models have achieved significant progress in developing self-driving algorithms. Despite their advantages, these algorithms typically require substantial amounts of data for effective training.
Xiangyi Liao, Zhenyu Shou, Xu Chen
doaj   +1 more source

Modelling Drivers' Behaviour as a Crash Risk Reduction Process

Promet (Zagreb), 2008
The evermore widespread use of microscopic traffic simulationin the analysis of road systems has refocused attention onsub models, including car-following and lane-changing models.In this research a microscopic model is developed whichcombines car ...
Seyyed Mohammad Sadat Hoseini, Manouchehr Vaziri   +1 more
doaj   +1 more source

A Model of Car-Following Behavior at Sags

, 2014
Sags are bottlenecks in freeway networks. The main reason is that the increase in slope has a negative effect on vehicle acceleration, which results in local changes in car-following behavior that reduce traffic flow capacity. Existing car-following models are not able to reproduce the acceleration behavior of drivers at sags and the resulting traffic ...
Goni Ros, B. (author), Knoop, V.L. (author), Schakel, W.J. (author), Van Arem, B. (author), Hoogendoorn, S.P. (author)   +4 more
openaire   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Extreme value analysis for safety benefit estimation of adaptive cruise control (ACC)

Traffic Safety Research
As new automated features enter the automotive market, we need methods to assess their safety in a rapid, proactive, and iterative way. The traditional way of relying on crash statistics does not meet these needs.
Alberto Morando
doaj   +1 more source