Results 51 to 60 of about 262,883 (261)

Extreme value analysis for safety benefit estimation of adaptive cruise control (ACC)

Traffic Safety Research
As new automated features enter the automotive market, we need methods to assess their safety in a rapid, proactive, and iterative way. The traditional way of relying on crash statistics does not meet these needs.
Alberto Morando
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Car-Following Driver Model Capable of Retaining Naturalistic Driving Styles

Journal of Advanced Transportation, 2020
The modeling of car-following behavior is an attractive research topic in traffic simulation and intelligent transportation. The driver plays an important role in car following but is ignored by most car-following models.
Jie Hu, Sheng Luo
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Developing a New Surrogate Safety Indicator Based on Motion Equations

Promet (Zagreb), 2014
Collision avoidance system (CAS), with the help of surrogate safety measures is a beneficial tool for reducing driver errors and preventing rear-end collisions.
Hamid Behbahani, Navid Nadimi, Hooman Alenoori, Mina Sayadi   +3 more
doaj   +1 more source

A Study on an Anthropomorphic Car-Following Strategy Framework of the Autonomous Coach in Mixed Traffic Flow

IEEE Access, 2020
In this study, to explore the demand characteristics of autonomous coaches in mixed traffic flow, two sections of an expressway were selected for vehicle experiments.
Chen Zhao, Siyang Jiang, Yi Lei, Chang Wang   +3 more
doaj   +1 more source

A Model of Car-Following Behavior at Sags

, 2014
Sags are bottlenecks in freeway networks. The main reason is that the increase in slope has a negative effect on vehicle acceleration, which results in local changes in car-following behavior that reduce traffic flow capacity. Existing car-following models are not able to reproduce the acceleration behavior of drivers at sags and the resulting traffic ...
Goni Ros, B. (author), Knoop, V.L. (author), Schakel, W.J. (author), Van Arem, B. (author), Hoogendoorn, S.P. (author)   +4 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source