Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
Supramolecular immunomodulatory hydrogelator potentiates CAR-T therapy with long-lasting endogenous immunity toward solid tumor eradication. [PDF]
Sci AdvJiang C +9 more
europepmc +1 more source
A Sustainable Bio‐Based Epoxy Thermoset as a High‐Performance Alternative to BPA‐Based Resins
Advanced Science, EarlyView.A rigid–flexible bio‐based epoxy network integrates soybean oil, lignin, and maleic anhydride to overcome the strength–toughness–sustainability trade‐off of conventional BPA epoxy. The thermoset delivers excellent performance as both a structural adhesive and a matrix for glass‐fabric composites, while enabling pH‐responsive degradation, environmental ...
Jiyun Qi +4 more
wiley +1 more source
Microfluidic Cytotongue system enables early, label-free detection of CAR-T-induced mechanical softening in tumor spheroids. [PDF]
Microsyst NanoengKim S, Seo GM, Bae J, Noort DV, Park S.
europepmc +1 more source
Efficient Polarization‐Entangled Photon‐Pair Generation by a Fiber‐In‐Line van der Waals Material
Advanced Science, EarlyView.Telecom‐wavelength polarization‐entangled photon pairs are generated in a van der Waals‐material‐integrated all‐fiber device via spontaneous parametric down‐conversion. The demonstrated fiberized quantum light source bridges emerging 2D nonlinear materials and practical quantum photonic systems, opening new opportunities for scalable fiber‐based ...
Jungseok Choi +11 more
wiley +1 more source
Bioengineered cell therapies for pediatric solid tumors: unmet needs and a measurement-integrated approach. [PDF]
Prog Biomed Eng (Bristol)Sandoval-Castellanos AM +4 more
europepmc +1 more source
Advanced Science, EarlyView.Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger +8 more
wiley +1 more source
Impact of varied oral processing on starch hydrolysis, bolus properties, and sensory texture attributes of mashed potatoes. [PDF]
J Sci Food AgricKhramova DS +5 more
europepmc +1 more source
Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module
Advanced Science, EarlyView.Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang +6 more
wiley +1 more source
Advanced Science, EarlyView.Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng +19 more
wiley +1 more source