Results 231 to 240 of about 11,974,013 (294)

A Patient-Derived Xenograft Repository Capturing Clinical and Molecular Heterogeneity of Large B-cell Lymphoma. [PDF]

Blood Cancer Discov
Yang H, Arita K, Bowman K, Chihara D, Henderson J, Rost G, Rojas E, Parsons S, Lakra P, Abedin AS, Neelapu SS, Strati P, Nastoupil LJ, Fayad LE, Iyer SP, Rodriguez MA, Hagemeister FB, Malpica L, Lee H, Hilton LK, Scott DW, Davis RE, Flowers CR, Westin JR, Inghirami G, Vega F, Green MR.   +26 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Anti-BCMA CAR-NK Cells Reveal Enhanced Cytolytic and Secretory Responses Against Myeloma Cells. [PDF]

APMIS
Divsalar B, Kiani J, Abroun S, Soleimani M.   +3 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Chimeric antigen receptor T-cell therapy and cardiovascular outcomes in US Medicare beneficiaries. [PDF]

Eur Heart J
Zaghlol R, Deych E, Ladin DA, Russler-Germain DA, Schiffer W, Baral N, Waken RJ, Ky B, Joynt Maddox KE, Mitchell JD.   +9 more
europepmc   +1 more source

Deep‐Learning‐Driven High‐Fidelity In Vivo Hyperspectral Fluorescence Imaging Under Extreme Photon‐Limited Conditions

Advanced Science, EarlyView.
Highly overlapping fluorescent signals become distinguishable in photon‐limited living organisms via advanced imaging with intelligent reconstruction. The resulting in vivo hyperspectral imaging capability reveals nanoplastic uptake and circulation in live zebrafish, providing a new approach for studying complex biological and environmental processes ...
Renjian Li, Shutao Wu, Kaixiang Li, Zhenyu An, Yuwen Ben, Guiye LI, Sunil Kumar, James Mcginty, Tawfique Hasan, Songnian Fu, Meng Zhang, LingLing Chen   +11 more
wiley   +1 more source

A Myeloid-Specific Endogenous TRP1-CAR Knock-in Mouse Model for Melanoma-Targeted Immunotherapy. [PDF]

Immunotargets Ther
Hao Y, Chen X, Wang M, Han J, Pan J, Zhang L, Yin X.   +6 more
europepmc   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Dynamic Assessment of the C-Reactive Protein-to-Albumin Ratio Improves Early Prediction of Severe Acute Pancreatitis: A Retrospective Cohort Study. [PDF]

Life (Basel)
Fofiu C, Nat L, Ioanovici AC, Boeriu A.
europepmc   +1 more source