Results 111 to 120 of about 14,957,077 (381)

Overcoming antigen loss in CAR T therapy with Vγ9Vδ2 CAR T-cells [PDF]

Immuno-Oncology and Technology
Vγ9Vδ2 T-cells demonstrate potent antitumor activity in vitro but, despite successful safety studies, the clinical benefit of Vγ9Vδ2 in adoptive cell therapy has been limited. One approach to enhance the therapeutic potential of Vγ9Vδ2 T-cells while maintaining their safety profile is genetic engineering to express a chimeric antigen receptor (CAR ...
M. Velasco Santiago, P. Aehnlich, T.M. Hulen, K.M. Jensen, G. Holmen Olofsson, Ö. Met, P. thor Straten   +6 more
openaire   +3 more sources

Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells [PDF]

, 2016
The success of adoptive T-cell therapies for the treatment of cancer patients depends on transferred T-lymphocytes finding and infiltrating cancerous tissues.
Ager, Elizabeth, Mohammed, Rebar N., Watson, Heulwen Angharad, Wehenkel, Sophie C.   +3 more
core   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity

Journal for ImmunoTherapy of Cancer
Background Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric antigen receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments of tumor tissues.
Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran   +10 more
doaj   +1 more source

CD22-CAR T Cells Induce Remissions in CD19-CAR Naïve and Resistant B-ALL

Nature Medicine, 2017
Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent effects in relapsed and/or refractory pre–B cell acute lymphoblastic leukemia (B-ALL), but antigen loss is a frequent cause of resistance to CD19-targeted immunotherapy.
T. Fry, N. Shah, R. Orentas, M. Stetler-Stevenson, C. Yuan, S. Ramakrishna, P. Wolters, Staci Martin, Cindy P. Delbrook, B. Yates, Haneen Shalabi, Thomas J. Fountaine, J. Shern, R. Majzner, D. Stroncek, M. Sabatino, Yang Feng, D. Dimitrov, Ling Zhang, S. Nguyen, Haiying Qin, B. Dropulić, Daniel W. Lee, C. Mackall   +23 more
semanticscholar   +1 more source

Overcoming the challenge of transduction of human T-cells with chimeric antigen receptor (CAR) specific for ERBB2 antigen [PDF]

, 2017
Breast cancer is one of the most common malignancies among woman. Decades of scientific study have linked the overexpression of ERBB2 antigen to aggressive tumors.
Abdullah, Syahril, Alarfaj, Abdullah A., Ding, Shirley Suet Lee, Koh, Avin Ee Hwan, Lim, Moon Nian, Mok, Pooi Ling, Munisvaradass, Rusheni, Subbiah, Suresh Kumar, Vellasamy, Shalini   +8 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

Vaccines
Background: The emergence of chimeric antigen receptor T-cell (CAR-T) immunotherapy holds great promise in treating hematologic malignancies. While advancements in CAR design have enhanced therapeutic efficacy, the time-consuming manufacturing process ...
Shih-Ting Tsao, Mingyuan Gu, Qinghui Xiong, Yingzhi Deng, Tian Deng, Chengbing Fu, Zihao Zhao, Haoyu Zhang, Cuicui Liu, Xiong Zhong, Fang Xiang, Fei Huang, Haiying Wang   +12 more
doaj   +1 more source

The CAR T Cell Story

healthbook TIMES. Oncology Hematology, 2019
During the entire 20^th^ century, chemotherapy and irradiation were the mainstay of non-surgical cancer treatment. In the past 20 years, however, cancer immunotherapy has been revolutionizing the field of oncology with ever-increasing pace.
Norman Russkamp, Thorsten Zenz
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source