Results 101 to 110 of about 293,272 (302)

CAR T cells combat cardiac fibrosis [PDF]

Nature Reviews Immunology, 2019
Engineered chimeric antigen receptor (CAR) T cells can be applied to reduce cardiac fibrosis and restore function in a mouse model of hypertensive heart failure, according to a new study published in Nature.
openaire   +4 more sources

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

Vaccines
Background: The emergence of chimeric antigen receptor T-cell (CAR-T) immunotherapy holds great promise in treating hematologic malignancies. While advancements in CAR design have enhanced therapeutic efficacy, the time-consuming manufacturing process ...
Shih-Ting Tsao, Mingyuan Gu, Qinghui Xiong, Yingzhi Deng, Tian Deng, Chengbing Fu, Zihao Zhao, Haoyu Zhang, Cuicui Liu, Xiong Zhong, Fang Xiang, Fei Huang, Haiying Wang   +12 more
doaj   +1 more source

Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia [PDF]

, 2018
BACKGROUND: In a single-center phase 1-2a study, the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel produced high rates of complete remission and was associated with serious but mainly reversible toxic effects in children and ...
Bader, P, Balduzzi, A, Baruchel, A, Bittencourt, H, Boissel, N, Boyer, M, Buechner, J, Davis, KL, De Moerloose, Barbara, Grupp, SA, Hiramatsu, H, June, CH, Krueger, J, Laetsch, TW, Lebwohl, D, Leung, M, Levine, BL, Martin, PL, Maude, SL, Mechinaud, F, Mueller, KT, Myers, GD, Nemecek, ER, Peters, C, Pulsipher, MA, Qayed, M, Rives, S, Schlis, K, Sen, K, Stefanski, HE, Taran, T, Verneris, MR, Wood, P, Yanik, GA, Zhang, Y   +34 more
core   +2 more sources

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Potential Application of CAR-NK Cells as an Ex Vivo Therapy for T-cell-related Diseases

Frontiers in Bioscience-Landmark
Anticancer therapeutics have evolved from small-molecule drugs to monoclonal antibodies and, more recently, to cell and gene therapies (CGTs). This progress has been driven by the pursuit of greater drug specificity, potency, and safety.
Daekee Kwon, Kyung-Sun Kang
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity [PDF]

, 2017
The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5(+) malignancy.
Austin, E, Burt, DJ, Byatte, AJ, Chester, KA, Gilham, DE, Guest, RD, Halford, SER, Hawkins, RE, Kirillova, N, Nabarro, S, Pillai, M, Rothwell, DG, Sharma, SK, Thistlethwaite, FC, Valle, JW, Wan, S, Westwood, NB   +16 more
core  

Galactic Cepheids with Spitzer: II. Search for Extended Infrared Emission

, 2010
A deep and detailed examination of 29 classical Cepheids with the Spitzer Space Telescope has revealed three stars with strong nearby extended emission detected in multiple bands which appears to be physically associated with the stars.
Barmby, P., Bono, G., Evans, N. R., Fazio, G. G., Huelsman, D., Marengo, M., Su, K. Y. L., Welch, D. L.   +7 more
core   +1 more source