Results 1 to 10 of about 4,106,944 (201)
Conventional CARs versus modular CARs [PDF]
Cancer Immunology, Immunotherapy, 2019 Abstract The clinical application of immune effector cells genetically modified to express chimeric antigen receptors (CARs) has shown impressive results including complete remissions of certain malignant hematological diseases. However, their application can also cause severe side effects such as cytokine release syndrome (CRS) or tumor ...
Feldmann, A. +5 more
openaire +2 more sources
CD28z CARs and Armored CARs [PDF]
The Cancer Journal, 2014 CD19-targeted chimeric antigen receptor (CAR) T cells are currently being tested in the clinic with very promising outcomes. However, limitations to CAR T cell therapy exist. These include lack of efficacy against some tumors, specific targeting of tumor cells without affecting normal tissue and retaining activity within the suppressive tumor ...
Hollie J, Pegram +2 more
openaire +2 more sources
Revista Iberoamericana de Automática e Informática Industrial RIAI, 2023 Este artículo presenta el diseño y desarrollo de una arquitectura electrónica bioinspirada en el sistema motor humano para sistemas de asistencia a la locomoción, como es en el caso de exoesqueletos de asistencia o de rehabilitación.
Gabriel Delgado-Oleas +4 more
doaj +1 more source
CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
Journal of Experimental & Clinical Cancer Research, 2022 AbstractAdoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made tremendous progress with five CAR T therapies approved by the US Food and Drug Administration for hematological malignancies. However, CAR immunotherapy in solid tumors lags significantly behind.
Kevin Pan +5 more
openaire +3 more sources
Kinetic theory of quantum transport at the nanoscale [PDF]
, 2004 We present a quantum-kinetic scheme for the calculation of non-equilibrium transport properties in nanoscale systems. The approach is based on a Liouville-master equation for a reduced density operator and represents a generalization of the well-known ...
Car, Roberto, Gebauer, Ralph
core +1 more source
Nutrición Hospitalaria, 2014 Introduction: The discovery of vitamin D muscle receptors in the last few years suggested a significant role in muscle tissue, pointing out athletes as a special group. Specific data are scarce.
Jara Valtueña +4 more
doaj +1 more source
Beyond 'anti-smacking': challenging parental violence and coercion [PDF]
, 2003 The anti-smacking lobby concentrates on persuading parents not to smack, and the government to prohibit smacking by law. There is much evidence that smacking children is unnecessary and dangerous, and yet smacking continues to be widely practised and ...
Alderson, Priscilla, Phillips, B
core +3 more sources
ANALYSIS OF ENERGY SAVING AND ENERGY EFFICIENCY ISSUES DURING OPERATION OF THE METRO ROLLING STOCK
Nauka ta progres transportu, 2016 Purpose.Nowadays a problem of significant power consumption of the rolling stock during its operation is a current issue. In connection with staged electricity rates increase further development of the rail electric transport, including metro rolling ...
A. V. Donchenko +4 more
doaj +1 more source
Safer recruitment? protecting children, improving practice in residential child care [PDF]
, 2007 In the wake of a number of high-profile cases of the abuse of children and young people in residential child care, there have been repeated calls for the improvement of recruitment and selection of residential child care staff.
Davidson, Jennifer +3 more
core +1 more source
Nauka ta progres transportu, 2017 Purpose. The analysis of the existing studies showed that the increasing of energy efficiency of metro rolling stock becomes especially important and requires timely solutions.
A. O. Sulym +4 more
doaj +1 more source