Results 41 to 50 of about 393,681 (269)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Micro/nanoplastics pollution: emerging challenges for aquatic animals and food crops
Frontiers in ToxicologyRecent reports from worldwide reveal that micro/nanoplastics (MNPs) are pervasive pollutants affecting all ecosystems and a wide range of organisms, including animals, plants, fish, humans, and microorganisms.
Shrutarshee Kundu +6 more
doaj +1 more source
Company Cars and Household Car Choices
SSRN Electronic JournalTax systems that favour company cars for personal use could cause households to have more cars. It could also affect the choice of fuel type. We investigate the relationship between household car choices and access to a company car through a difference-in-differences design using Norwegian microdata.
Gøril L. Andreassen +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Comparing autoencoder-based approaches for anomaly detection in highway driving scenario images
SN Applied Sciences, 2022 Autoencoder-based anomaly detection approaches can be used for precluding scope compliance failures of the automotive perception. However, the applicability of these approaches for the automotive domain should be thoroughly investigated.
Vasilii Mosin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Design Factors of Shared Situation Awareness Interface in Human–Machine Co-Driving
Information, 2022 Automated vehicles can perceive their environment and control themselves, but how to effectively transfer the information perceived by the vehicles to human drivers through interfaces, or share the awareness of the situation, is a problem to be solved in
Fang You, Xu Yan, Jun Zhang, Wei Cui
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Frontiers in Plant ScienceMaize (Zea mays L.) production is severely affected by diseases and insect pests, leading to significant yield losses when timely diagnosis and management interventions are not implemented.
Niranjan Singh +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source