Results 31 to 40 of about 1,073,242 (317)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Micro/nanoplastics pollution: emerging challenges for aquatic animals and food crops

Frontiers in Toxicology
Recent reports from worldwide reveal that micro/nanoplastics (MNPs) are pervasive pollutants affecting all ecosystems and a wide range of organisms, including animals, plants, fish, humans, and microorganisms.
Shrutarshee Kundu, Neeraj Kumar, Paritosh Kumar, Basavaraj PS, Ajay Kumar Singh, Dipti Godse, Kotha Sammi Reddy   +6 more
doaj   +1 more source

Design of Proactive Interaction for In-Vehicle Robots Based on Transparency

Sensors, 2022
Based on the transparency theory, this study investigates the appropriate amount of transparency information expressed by the in-vehicle robot under two channels of voice and visual in a proactive interaction scenario.
Jianmin Wang, Tianyang Yue, Yujia Liu, Yuxi Wang, Chengji Wang, Fei Yan, Fang You   +6 more
doaj   +1 more source

Company Cars and Household Car Choices

SSRN Electronic Journal
Tax systems that favour company cars for personal use could cause households to have more cars. It could also affect the choice of fuel type. We investigate the relationship between household car choices and access to a company car through a difference-in-differences design using Norwegian microdata.
Gøril L. Andreassen, Askill Harkjerr Halse   +1 more
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Transforming risk into resilience: a review of insurance strategies for sustainable shrimp aquaculture in India and beyond

Frontiers in Sustainable Food Systems
Shrimp is a key commodity constituting one-third of the global annual seafood trade of USD 171 billion (2024) constituting for approximately 25% of the agricultural trade.
Ravisankar T., Prasanna Kumar Patil, Geetha R., Sairam C. V., Kumaran M., Muralidhar M., Ananda Raja R., Kavibharathi S. M., Testimona A., Venkateswarlu Podili, Kuldeep K. Lal   +10 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Numerical Process Simulation Validation of a Light Electronic Enclosure in Compliance With Required High-Quality Standards by the Automotive Industry

Advances in Materials Science and Engineering
The EU has challenged automotive manufacturers to meet ambitious CO2 reduction targets. To achieve this goal, it is necessary to resort to all types of solutions, including car weight reduction.
Catia Araujo, Silvia Cruz, Ricardo Freitas, Susana Silva, Anibal Portinha, Pedro Bernando   +5 more
doaj   +1 more source