Results 21 to 30 of about 1,073,242 (317)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Road to Safety: A Review of Uncertainty and Applications to Autonomous Driving Perception

Entropy
Deep learning approaches have been gaining importance in several applications. However, the widespread use of these methods in safety-critical domains, such as Autonomous Driving, is still dependent on their reliability and trustworthiness.
Bernardo Araújo, João F. Teixeira, Joaquim Fonseca, Ricardo Cerqueira, Sofia C. Beco   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Sex-specific gut microbiome dynamics in Labeo catla: links to reproductive hormones, metabolic dimorphism, and environmental factors

Frontiers in Microbiology
IntroductionGut microbiota play a critical role in aquaculture by enhancing nutrient metabolism, digestion, immune response, and reproductive performance in fish.
Jitendra Kumar Sundaray, Madhusmita Mohapatra, Avinash Rasal, Uday Kumar Udit, Sriprakash Mohanty, Debasrita Mohanty, Ipsita Iswari Das, Lakshman Sahoo, Pramoda Kumar Sahoo   +8 more
doaj   +1 more source

A Taxonomy for Heavy-Duty Telemanipulation Tasks Using Elemental Actions

International Journal of Advanced Robotic Systems, 2013
In the maintenance of large scientific facilities, telemanipulation procedures can involve various subprocedures which in turn are made up of a sequence of subtasks.
Alexander Owen-Hill, José Breñosa, Manuel Ferre, Jordi Artigas, Rafael Aracil   +4 more
doaj   +1 more source

Presencia de sintomatología ansiosa en niños, niñas y adolescentes de 8 a 16 años de edad en Sincelejo (Sucre): una comparación entre hijos de desplazados y de no desplazados

Psicoespacios, 2016
El desplazamiento en Colombia es una situación problemática que afecta a la población más vulnerable y que puede producir secuelas físicas y mentales.
Diego Pérez Vásquez, Tady Regino Torres, Nancy Gómez Oyola, Sandra Castillo Santis, Kelly Romero-Acosta   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Machine learning and time-series approaches for forecasting bacterial blight of pomegranate

Frontiers in Plant Science
Bacterial blight, caused by Xanthomonas axonopodis pv. punicae, poses a significant threat to pomegranate (Punica granatum L.) cultivation, resulting in considerable yield losses.
Manoj Choudhary, Niranjan Singh, Meenakshi Malik, Meenakshi Arya, P. N. Meena, S. M. Haldhar, Mukesh Khokhar, Yukti Chandervanshi, Umesh Saini, Niharika Shoeran   +9 more
doaj   +1 more source

CARs of the future [PDF]

American Journal of Hematology, 2019
CAR T cells have revolutionized the treatment of relapsed and refractory CD19‐positive leukemia and lymphoma. Unfortunately, the majority of patients treated will not achieve durable remissions. Reasons for these suboptimal clinical outcomes can be tied back to intrinsic CAR T cell design and manufacturing processes, factors that are highly amenable to
Anthony F, Daniyan, Renier J, Brentjens
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source